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Kevin M Baskin,
Mark J Hogan,
Manrita K Sidhu,
Bairbre L Connolly,
Richard B Towbin,
Wael E A Saad, Josee Dubois,
Manraj K S Heran,
Francis E Marshalleck,
Donald L Miller,
Derek Roebuck,
Michael J Temple,
T Gregory Walker,
John F Cardella
Pediatric Radiology 10/2011; · 1.67 Impact Factor
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Kevin M Baskin,
Mark J Hogan,
Manrita K Sidhu,
Bairbre L Connolly,
Richard B Towbin,
Wael E A Saad, Josee Dubois,
Manraj K S Heran,
Francis E Marshalleck,
Donald L Miller,
Derek Roebuck,
Michael J Temple,
T Gregory Walker,
John F Cardella
Journal of vascular and interventional radiology: JVIR 09/2011; 22(12):1647-55. · 1.81 Impact Factor
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Manraj K S Heran,
Francis Marshalleck,
Michael Temple,
Clement J Grassi,
Bairbre Connolly,
Richard B Towbin,
Kevin M Baskin, Josee Dubois,
Mark J Hogan,
Sanjoy Kundu,
Donald L Miller,
Derek J Roebuck,
Steven C Rose,
David Sacks,
Manrita Sidhu,
Michael J Wallace,
Darryl A Zuckerman,
John F Cardella
Pediatric Radiology 02/2010; 40(2):237-50. · 1.67 Impact Factor
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ABSTRACT: Hemangiomas of infancy are benign vascular tumors frequently encountered in pediatrics. Medical treatment (corticosteroids, interferon, chemotherapy, embolization and radiation) in high-risk hemangioma cases could greatly benefit from the addition of new and safer therapies. The rapid growth of hemangiomas during the proliferative phase occurs secondary to a process of local uncontrolled angiogenesis, involving potent mediators such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF). We hypothesize that omega-3 fatty acids, naturally occurring nutrients of proven health benefit to infants, could become an alternative or an adjuvant treatment for hemangiomas, by slowing down their rapid proliferation phase through anti-angiogenic and anti-tumoral effects. Suggested mechanisms of action of omega-3 fatty acids include the downregulation of VEGF and bFGF, and the suppression of pro-angiogenic eicosanoids such as cylooxygenase-2. In this article, we review recent animal and human studies using dietary omega-3 fatty acids supplements, alone or in conjunction with chemotherapy, for the treatment of a variety of tumors dependent on angiogenesis for growth. Available murine hemangioma models offer the opportunity to determine optimal omega-3 fatty acid dose, while taking in account related immunohistochemical markers, clinical outcome and secondary effects, before planning clinical trials. Lessons learned in hemangiomas of infancy may have a broad impact in understanding the phenomenon of dysregulated angiogenesis in cancer research.
Medical Hypotheses 02/2006; 66(6):1121-4. · 1.39 Impact Factor
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Sanna Toiviainen-Salo,
Laurent Garel,
Andrée Grignon, Josee Dubois,
Françoise Rypens,
Jacques Boisvert,
Gilles Perreault,
Jean Claude Decarie,
Denis Filiatrault,
Chantale Lapierre,
Marie-Claude Miron,
Nancy Bechard
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ABSTRACT: This review article aims at summarizing the data regarding fetal and neonatal hydronephrosis, at correlating controversial data with the differences in the practice of obstetrical sonography from one country to another, and finally, at presenting our own criteria for fetal renal collecting system dilatation along with our own guidelines of postnatal investigation.
Pediatric Radiology 08/2004; 34(7):519-29. · 1.67 Impact Factor
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ABSTRACT: The authors describe a hepatic pseudoaneurysm following laparoscopic cholecystectomy in a child. It arose from a hepatic artery that was ligated during surgery and was supplied by collaterals from the superior right branch. Because of the risk of hepatic infarction and recanalization of the pseudoaneurysm by new collaterals, the authors decided not to occlude the superior right branch, but to embolize the aneurysm itself with cyanoacrylate. Since the intra-arterial approach was not feasible, a transhepatic puncture was successfully performed.
Pediatric Radiology 02/2003; 33(1):24-6. · 1.67 Impact Factor
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ABSTRACT: The importance of early treatment of varicocele, to prevent testicular damage is widely accepted. Surgical treatment of varicocele has been the standard method of therapy, but recently a less invasive procedure was introduced and utilized mostly in Europe. The authors reviewed their experience with percutaneous embolization and sclerotherapy to assess the feasibility and outcome of this approach in children.
The authors conducted a retrospective study including all patients who underwent percutaneous embolization and sclerotherapy for varicocele in the authors' institutions for the last 10 years. Clinical data, investigation, pre and postintervention management, and the technique of the procedure, including sedation and anesthesia when needed, were collected from the charts. Follow-up was obtained from the chart or by phone.
Between 1991 and 2001, 41 patients underwent 43 percutaneous interventions. The median age was 14 years (range, 10 to 20 years). All but 2 were injected with a sclerosing agent; in 26 cases coils were added. All procedures except one were done under local anesthesia with sedation. Only 2 patients were admitted overnight, and 5 patients had minor complications. The average procedure time was 55 minutes. Follow-up data were obtained in 39 patients (95%), with a mean follow-up of 22 months. A total of 89.1% of those who were injected have satisfactory results (cured or improved) without the need for further procedures. Six patients required surgery post-percutaneous procedure, 4 because of persistent or recurrent varicocele and 2 because of technical failure.
Percutaneous embolization is a safe and effective treatment of varicocele in children with technical success in 95% and therapeutic success in 89%. It now is the authors' first treatment modality for this disease.
Journal of Pediatric Surgery 06/2002; 37(5):783-5. · 1.45 Impact Factor
