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ABSTRACT: An association between Birt-Hogg-Dubé syndrome (BHDS) and colon cancer remains conjectural, but herein we describe a case who may illustrate a significant link between them. The 60-year-old woman was diagnosed at 28 years of age with colon carcinoma and familial adenomatous polyposis (FAP). She also had repeated pneumothoraces, and was diagnosed with BHDS following the finding of pneumothorax in her son. We confirmed the presence of germline mutations in both her folliculin (FLCN) and adenomatous polyposis coli (APC) genes. The family pedigree suggested that a de novo FLCN mutation might have contributed to the development of colon carcinoma at a younger age than her family members.
Internal Medicine 01/2012; 51(13):1789-92. · 0.94 Impact Factor
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ABSTRACT: An 83-year-old man had been prescribed clopidogrel for pontine infarction since 8 months previously, and had had a cough for the last 2 weeks of this period. Laboratory examinations on admission showed a marked increase in eosinophils and elevated serum immunoglobulin E levels. Chest radiography showed bilateral ground-glass opacities, mild reticulation, and interlobar pleural effusion in the minor fissure. After clopidogrel was discontinued his symptoms resolved, and his laboratory tests showed normal results. Bronchoalveolar lavage also showed an increase in eosinophils, and transbronchial biopsy revealed infiltration of eosinophils in the subepithelium of the bronchial mucosa. On the basis of these findings, we diagnosed eosinophilic pneumonia induced by clopidogrel. Reports on cases of lung diseases caused by anti-platelet drugs are rare. To the best of our knowledge, this case is the first report on clopidogrel-induced eosinophilic pneumonia.
Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society. 11/2011; 49(11):838-42.
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ABSTRACT: A 68-year-old woman was brought by ambulance because of sudden choking sensation and dyspnea after coughing. A physical examination showed hoarseness and blood-stained sputum. A chest computed tomography (CT) showed bilateral diffusely-distributed ground-glass opacity. A bronchoscopy examination revealed a large nodule on the left larynx and bloody bronchoalveolar lavage fluid. We diagnosed negative pressure pulmonary hemorrhage (NPPH) based on suspected upper-airway obstruction, but it resolved without further treatment. We found no other causes. We report a rare case of NPPH due to a giant vocal cord nodule.
Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society. 10/2011; 49(10):733-8.
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ABSTRACT: A 60-year-old woman had received adjuvant chemotherapy after abdominal hysterectomy for clear cell carcinoma of the endometrium. She had no history of allergy. She was admitted to our hospital because of massive pleural effusion. She underwent drainage of left-side malignant pleural effusion followed by chemical pleurodesis with OK-432 via a chest tube. Ten minutes after administration of OK-432 to the thoracic cavity, she complained of dyspnea and showed general flushing. Since the clinical course suggested drug-induced anaphylactic reaction, she was immediately treated with an adrenaline subcutaneous injection and methylprednisolone sodium succinate intravenous injection. However, the respiratory insufficiency progressively deteriorated and mechanical ventilation was needed for the next 3 days. This is the first published case of anaphylactic reaction to OK-432 pleurodesis. In Japan, OK-432 is a key drug used for pleurodesis and we should consider possible serious adverse reactions include anaphylactic reaction.
Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society. 10/2009; 47(10):965-8.
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ABSTRACT: The patient was a 95-year-old-man admitted to the urological section of our hospital because of hematuria. Transurethral resection of the bladder tumor (TUR-Bt) was performed. This tumor was diagnosed pathologically as bladder cancer (transitional cell carcinoma Grade 3 pT1). After 8 months, local reccurence was seen and TUR-Bt was performed. (pTa). After 1 month, his chest radiograph and computed tomogram showed a mass shadow in the left upper lung field. Cystoscopy did not reveal a local reccurence. The patient's condition worsened, and he died of respiratory failure after about 1 month. At autopsy, pathologic studies of the lung tumor revealed transitional cell carcinoma, and local recurrence was not seen. We report a rare case of pulmonary metastases from superficial bladder cancer without local reccurence.
Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society. 07/2008; 46(6):501-4.
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Kengo Murata,
Satoshi Ishikawa, Yoshimasa Horie,
Satoshi Kominami,
Yasuhiro Tomita,
Yasuhisa Oode,
Futoshi Toyoda,
Yoshirou Ootsuki,
Shinichi Shimizu,
Hiroshi Kobayashi,
Hidenori Nakamura
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ABSTRACT: A 60-year-old man was admitted for investigation of an abnormality detected in chest radiography: a giant tumor with calcification in the right middle lung field. A computed tomography (CT) scan revealed multiple tumors with calcification on the posterior chest wall. Histological analysis of the tumor specimen obtained by surgical biopsy demonstrated an increasing number of plasma cells accompanied with the deposition of amyloid. A bone marrow biopsy contained over 50% of plasma cells. We therefore diagnosed these tumors as multiple myeloma. It has been reported that multiple myeloma is usually characterized by osteolytic lesions; osteosclerotic changes are rare. Multiple myeloma should be taken into account as one of the causes of a chest wall tumor even if it is diffusely calcified.
Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society. 12/2003; 41(11):846-50.
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ABSTRACT: A 44-year-old man visited our hospital because of right chest pain. Pleural effusion in the right lung was detected on a chest radiograph. A chest CT scan demonstrated no abnormal lesions in either lung field, but passive atelectasis due to the pleural effusion was present. Since many eosinophils were found in the exudative pleural effusion, a parasitic infection was suspected. An enzyme-linked immunosorbent assay test led to a diagnosis of eosinophilic pleural effusion by dirofilariasis. Pleural effusion disappeared spontaneously and the level of anti-Dirofilaria immitis antibody decreased. Continued careful observation is necessary in such cases.
Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society. 06/2003; 41(5):347-50.
