Levent Ozgonenel

Istanbul Training and Research Hospital, İstanbul, Istanbul, Turkey

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Publications (11)21.08 Total impact

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    ABSTRACT: The position of metacarpophalangeal (MCP) joints may be an important factor affecting the efficacy of splinting in patients with carpal tunnel syndrome (CTS). The aim of the present study was to compare the efficacy of a neutral volar static wrist splint with a neutral volar static wrist and MCP splint in patients with CTS.METHODS: Fifty-four hands were included into the study. A neutral volar static wrist splint was given to the symptomatic hands of the patients in group 1 while a neutral volar static wrist and MCP splint was given to the symptomatic hands of the patients in group 2. Evaluation parameters were Visual Analog Scale for pain severity (VASp), grip strength, pinch strength, electrophysiologic tests and CTS Questionnaire (CTSQ) at baseline and four weeks later. At baseline there was no difference between groups. The intergroup comparison of the improvement showed significant differences in VASp at rest, grip strength, pinch strength and CTSQ functional capacity scores between groups in favor of wrist MCP splint. Although there were significant improvements with regard to sensory amplitude and motor latency in both groups after therapy, the differences between groups were not at the level of significance. The position of MCP joints seems to be an important factor for the treatment of CTS and should be considered while prescribing a splint to the patients with CTS.
    Journal of Back and Musculoskeletal Rehabilitation 12/2014; DOI:10.3233/BMR-140580 · 1.04 Impact Factor
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    ABSTRACT: Stroke is acute vascular deterioration of cerebral functions and 2nd leading cause of death. As population gets older, as well as the increasing prevalence of stroke and disability from chronic disease, the demand for rehabilitation care will continue to rise. There is need for evidence based rehabilitation approaches and rehabilitation outcomes should be proved by objective questionnairres to qualify the process. To present the functional outcomes of stroke rehabilitation process among functional impairment measure evaluation. Determine the contributing factors on functional gain. Retrospectively assessment of data of 142 posttroke patients performed. In addition to demographical and clinical properties, functional outcomes with functional impairment measurement (FIM) and motor evaluation by Brunnstrom Motricitiy Index were recorded. Risk factors for stroke were questionned also. The mean of ages was 64.30 ± 11.9 years, male/female ratios were 47.2%/ 52.8%. The functional gain was 20.4% in M-FIM, 14.7% in C-FIM. Better outcomes gained by the patients who stayed longer than 15 days (ANOVA, p: 0.000) and who had hemorrhagic etiology (MannWhitney U, p: 0.048), meanwhile there was no significant difference in gender and plegic side groups on both Motor-FIM and Cognitive-FIM gains (p > 0.05, MannWhitney U). Regression models exhibited highest impact on the M-FIM gain were the admission M-FIM scores and DM (adjusted Rsquare: 0.173, p: 0.000). Admission C-FIM scores had positive correlation with discharge C-FIM scores (r: 0.917, p: 0.000). Although older age was the negative determinant of C-FIM gain (r: -0.202, p: 0.016). We obtained the risk factor distribution 71.8% for HT, 29.6%for CAD, 25.6% for smoking, 16.2% for TIA and 33.1% for DM. All had negative impact on functional outcomes but DM had significantly (regression analysis p < 0.05). Improvement by rehabilitation programme determined by FIM scores. Data provided about the poststroke patients and present risk factors. Still there exists similar ratios of risk factors as studies before eventhough prevention recommendations.
    Neurorehabilitation 01/2014; 34(3). DOI:10.3233/NRE-141060 · 1.74 Impact Factor
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    ABSTRACT: Objectives: The primary aim of this study was to assess the possible relationship among the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Bath Ankylosing Spondylitis Functional Index (BASFI), and two Ankylosing Spondylitis Disease Activity Score (ASDAS) including the C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) scores in patients with ankylosing spondylitis (AS). The secondary aim was to investigate gender differences in terms of disease activity scores and functional status. Patients and methods: Five hundred patients (158 females, 342 males; mean age 37.2 +/- 9.9 years; range 15 to 70 years) with AS were enrolled. Disease activity was assessed through the BASDAI, ASDAS-CRP and ASDAS-ESR, while functional status was evaluated by the BASFI. Results: The mean BASDAI, ASDAS-CRP, ASDAS-ESR, and BASFI scores were 3.71 +/- 2.26, 1.65 +/- 0.83, 2.59 +/- 1.12, and 2.68 +/- 2.38, respectively. The BASDAI and ASDAS-ESR values of the female patients with AS were significantly higher than those of the males. The BASDAI and BASFI were significantly associated with the two ASDAS scores. According to the BASDAI, 46.6% of the patients had a high disease activity and had significantly higher values in terms of symptom duration, compared to those with lower BASFI, and two ASDAS scores. The ASDAS-CRP scores of the disease activity indices were similar in both genders. Conclusion: Our study results suggest that the two ASDAS scores are significantly associated with the disease activity and functional status. We believe that using ASDAS-CRP indices is more suitable for a disease activity parameter in further studies involving patients with AS in both genders, however not analyzing gender differences.
    Annals of the Rheumatic Diseases 01/2014; 71(Suppl 3):688-688. DOI:10.1136/annrheumdis-2012-eular.868 · 9.27 Impact Factor
  • Firuzan Altin, Ozer Burnaz, Levent Ozgonenel, Nil Caglar
    05/2013; DOI:10.1530/boneabs.1.PP9
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    ABSTRACT: The home-based exercise therapy recommended to the patients with ankylosing spondylitis (AS) is a simply applicable and cheap method. The aim of this study was to investigate the effects of home-based exercise therapy on pain, mobility, function, disease activity, quality of life, and respiratory functions in patients with AS. Eighty patients diagnosed with AS according to the modified New York criteria were included in the study. Home-based exercise program including range of motion, stretching, strengthening, posture, and respiratory exercises was practically demonstrated by a physiotherapist. A training and exercise manual booklet was given to all patients. Patients following home-based exercise program five times a week at least 30 min per session (exercise group) for 3 months were compared with those exercising less than five times a week (control group). Visual analog scale pain (VASp) values at baseline were significantly higher in the exercise group. The exercise group showed improvements in VASp, tragus-wall distance, morning stiffness, finger-floor distance, modified Schober's test, chest expansion, the Bath Ankylosing Spondylitis Disease Activity Index, the Bath Ankylosing Spondylitis Functional Index, Ankylosing Spondylitis Quality of Life Questionnaire (ASQoL), forced expiratory volume in first second, and forced vital capacity at third month. There was significant difference in ASQoL scores between the two groups in favor of the exercise group at third month. Regular home-based exercise therapy should be a part of main therapy in patients with AS. Physicians should recommend that patients with AS do exercise at least five times a week at least 30 min per session.
    Clinical Rheumatology 06/2011; 31(1):91-7. DOI:10.1007/s10067-011-1791-5 · 1.77 Impact Factor
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    ABSTRACT: Rheumatoid arthritis (RA) is an autoinflammatory disease with a genetic background. The synoviocytes in RA shows cellular transformation with tumor-like features, and RA patients have genomic instability and relaxation of DNA repair mechanisms. The polymorphisms in BER repair pathway genes, XRCC1 and OGG1, may change the response to inflammation via altered DNA repair capacity. In this study, we aimed to investigate the relationship between the risk of RA and XRCC1 Arg194Trp, Arg399Gln, and OGG1 Ser326Cys polymorphisms in a group of Turkish RA patients. XRCC1 Arg194Trp, Arg399Gln, and OGG1 Ser326Cys polymorphisms were investigated by PCR-RFLP method in 100 RA patients and 158 healthy control subjects. The results were statistically analyzed by calculating the odds ratios (OR) and their 95% confidence intervals (95% CI) using the χ(2)-tests. RA patients in this study had significantly higher frequencies of XRCC1 Arg399Gln polymorphism in both homozygote (GG) (35%, OR: 7.78 [95% CI: 3.65-16.59], P < 0.001) and heterozygote (AG) forms (41%, OR: 2.17 [95% CI: 1.19-3.96], P < 0.01) and also increased frequency of 399Gln (G) allele (55%, OR:2.99 [95% CI: 1.67-5.37], P < 0.001). We conclude that XRCC1 Arg194Trp, and OGG1 Ser326Cys polymorphisms are not associated with RA; however, Arg399Gln polymorphism is a significant risk factor of RA, and carriers of 399Gln (G) allele have greater risk of RA.
    Rheumatology International 05/2011; 32(5):1265-9. DOI:10.1007/s00296-010-1725-6 · 1.63 Impact Factor
  • 01/2011; 12(1):19-24. DOI:10.5505/1304.8503.2011.41736
  • 01/2011; 12(1):5-10. DOI:10.5505/1304.8503.2011.96168
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    ABSTRACT: Vascular endothelial growth factor (VEGF) is known to be involved in the pathogenesis of rheumatoid arthritis (RA). In order to elucidate the association between VEGF levels and RA disease activity, VEGF concentrations were measured in RA patients at different phases and severity levels. Thirty-eight healthy subjects and 40 patients with RA were prospectively included in the study. Subjects were further categorized into four subgroups (high, moderate, low, or remission) using the disease activity score-28 (DAS28) scoring system. VEGF levels were significantly higher in patients than controls (p < 0.001). VEGF levels differed significantly in controls, early and late-phase RA patients (p = 0.002). A significant difference was found between controls and patients with high RA disease activity scores (p < 0.0001). VEGF levels were not correlated with age (r = -0.016; p = 0.921) or sex (r = 0.209; p = 0.921). VEGF values were correlated with erythrocyte sedimentation rate (r = 0.445; p = 0.004), but was not correlated with serum rheumatoid factor levels (r = -0.130; p = 0.424) in the patient group. In conclusion, higher VEGF levels are associated with late phase and high disease activity in RA, independent of age and sex.
    Clinical Rheumatology 05/2010; 29(5):473-7. DOI:10.1007/s10067-009-1343-4 · 1.77 Impact Factor
  • Sule Tutun, Levent Ozgonenel, Esra Cetin, Ebru Aytekin
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    ABSTRACT: Synovial chondromatosis (SC) is a rarely encountered benign disease of unknown etiology characterized by multiple joint mouse, as well as metaplastic cartilage points in the joint, bursa and tendon sheaths. Although single joint involvement is frequently encountered, multiple joint involvements may also occur. In this study, two patients with SC in the right shoulder joint and in both ankles were presented, reviewed according to literature.
    Rheumatology International 10/2009; 31(5):687-9. DOI:10.1007/s00296-009-1224-9 · 1.63 Impact Factor
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    ABSTRACT: Objectives Based on the hypothesis that vascular endothelial growth factor (VEGF) is closely associated with the pathophysiology of rheumatoid arthritis (RA), we analyzed serum VEGF concentrations in RA patients at various stages and evaluated its relationship to clinical and laboratory variables. Design & Methods Thirty-eight healthy subjects and forty RA patients were chosen prospectively. Results Serum levels of VEGF (180.40 ± 124.89 pg/ml) were significantly higher (p < 0.001) in patients with RA than in controls (111.53 ± 64.29 pg/ml). In patients group, slightly positive correlation was found between VEGF levels and the following: disease duration (r = 0.288, p = 0.072), disease activity score 28 (DAS 28) (r = 0.301, p = 0.059) and ESR (r = 0.445, p = 0.004). Conclusion Our results show that VEGF levels may be a valuable prognostic factor as a marker of angiogenesis but its diagnostic efficiency was not high. While the serum levels of VEGF is correlated with inflammation parameters, measurement of this marker can be a useful method for monitoring the disease activity of RA.
    Clinical Biochemistry 03/2009; 42(4):343-343. DOI:10.1016/j.clinbiochem.2008.09.075 · 2.23 Impact Factor