ABSTRACT: To study the level of intelligence in children with Duchenne muscular dystrophy (DMD), and the relationship between the level of intelligence and gene mutations.
One hundred and two children with DMD between January 2009 and March 2011 were enrolled. DMD gene detection was performed through the multiplex ligation-dependent probe amplification (MLPA) in 84 cases. The level and the structure of intelligence were evaluated by Chinese Wechsler Intelligence Scale for Children (C-WISC) in 50 children with DMD (≥6 years old; DMD group) and in 50 age-and gender-matched healthy children (control group).
The average intelligence quotient (IQ) was 84±21 in 102 children with DMD. Thirty patients (29.4%) had the full intelligence quotient (FIQ) less than 70. The FIQ, verbal intelligence quotient (VIQ), performance intelligence quotient (PIQ) and the scores of 11 sub-tests of intelligence in the DMD group were significantly lower than those in the control group (P<0.01). The IQ in patients with gene mutations at exon 56-79 was the lowest (59.3±11.9), followed by in patients with gene mutations at exon 45-55 (88.6±1.9), at exon 1-29 (97.5±9.6) and at exon 30-44 (102.8±3.8) (P<0.01).
The FIQ, VIQ and PIQ in children with DMD are lower than those in healthy children. There is association between mental retardation and gene mutations.
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 10/2011; 13(10):804-7.
ABSTRACT: To study the sensory integration function in children with primary nocturnal enuresis (PNE).
The sensory integration function was assessed by the Childhood Sensory Integration Ability Development Checklist in 70 children with PNE and was compared with that in 74 normal children(control group).
The incidence of sensory integration dysfunction (76%) in the PNE group were significantly higher than that in the control group (35%; P<0.01). Severe sensory integration dysfunction occurred in more children in the PNE group compared with the control group (39% vs 18%; P<0.01). The scores of all sensory integration indexes revealed by sensory integration function testing in the PNE group were significantly lower than those in the control group (P<0.01).
The majority of children with PNE have sensory integrative dysfunction which presents in various aspects. It is necessary to assess the sensory integration function in children with PNE.
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 05/2010; 12(5):341-3.
ABSTRACT: To study the effect of cesarean section birth based on different indications on attentiveness in school children.
A total of 308 school children were assigned to three groups according to their birth model: natural delivery (n = 105), cesarean section due to social factors (n = 101) or medical factors (n = 102). The integrated visual and auditory continuous performance test (IVA-CPT) was performed for assessing attentiveness.
The IVA-CPT demonstrated that there were significant differences in the quotients of combination control, auditory response control, combination attention, auditory attention, visual attention, auditory vigilance, visual concordance, visual vigilance and visual attention among the three groups (p<0.05). The results of the IVA-CPT in the group of cesarean section due to medical factors was obviously poorer than that of the natural delivery group and the group of cesarean section due to social factors. However no significant differences were observed between the groups of natural delivery and of cesarean section due to social factors.
Cesarean section itself has no significant impacts on attentiveness in school children, while medical indications for cesarean section may contribute to major cause of attention deficit disorder.
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 11/2009; 11(11):913-6.
ABSTRACT: To study the intelligence level and structure in school age children with fetal growth restriction (FGR).
The intelligence levels were tested by the Wechsler Children Scales of Intelligence (C-WISC) in 54 children with FGR and in 84 normal children.
The full intelligence quotient (FIQ), verbal IQ (VIQ) and performance IQ (PIQ) in the FGR group were 105.9+/-10.3, 112.4+/-11.2 and 97.1+/-10.6 respectively, and they all were in a normal range. But the PIQ was significantly lower than that in the control group (104.8+/-10.5; p<0.001), and the picture arrangement and the decipher subtest scores were significantly lower than those in the control group (p<0.01). The scores of perception/organization and memory/attention factors in the FGR group were 99.8+/-11.1 and 116.3+/-14.4, respectively, which were inferior to those in the control group (104.6+/-11.5 and 113.4+/-14.5 respectively; p<0.05).
The total intelligence level of children with FGR is normal, but there are imbalances in the intelligence structure and dysfunctions in performance ability related to right cerebral hemisphere. Performance trainings should be done from the infancy in children with FGR.
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 10/2009; 11(10):833-5.