M Añaños

Hospital Universitario Miguel Servet, Caesaraugusta, Aragon, Spain

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Publications (6)8.11 Total impact

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    ABSTRACT: A 61-year-old male patient with microbiological diagnosis of L3-L4 spondylodiscitis and persist pain underwent a (67)Ga scintigraphic study to assess the antibiotic treatment response. Pathological uptake foci in vertebral bodies of L2 and L4 were observed in the (67)Ga planar scintigraphy. A SPECT low-dose CT of the lumbar spine was performed as part of anatomical correlated protocol, detecting an active spondylodiscitis in L3-L4 and a second uptake foci in L2 that was identify as a Schmorl's node. In this case the SPECT-CT hybrid image allowed us to avoid a false positive diagnosis to by locate and characterize an image with abnormal uptake of (67)Ga, improving the test specificity and avoiding a wrong diagnosis.
    Revista Española de Medicina Nuclear 10/2009; 28(6):288-90. · 0.89 Impact Factor
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    ABSTRACT: A 22-year-old woman, diagnosed 7 years ago with low-grade astrocytoma in the left mesencephalon, presented with an initial clinical picture of severe intention and resting tremor in the right limbs. The tumour was treated with radiation therapy, and currently no signs of progression appear in the radiological control examinations, although the symptoms still persist and prevent the patient from carrying out daily activities. The last radiological exam (A) showed a calcified tumour in the left thalamus and mesencephalon, without structural affectation in the basal ganglia, so a functional assessment of the nigrostriatal system through a combined study of presynaptic dopamine transporters and postsynaptic D2 receptors was performed [1]. The study performed with [ 123 I]FP-CIT SPECT (B) shows absence of uptake in the left striatum and preserved uptake in the contralateral one. These findings suggest the existence of an interruption of the left nigrostriatal connections, with integrity of the right nigrostriatal pathway, consistent with the anatomical location of the tumour [2]. The study of D2 receptors with [ 123 I]IBZM SPECT (C) demonstrates intense uptake of the radiotracer in the left striatum and normal uptake in the right D2 postsynaptic receptors. The discrepancy between the study of receptors and transporters can be explained by upregulation of the left postsynaptic D2 receptors [3, 4], secondary to denervation of the left nigrostriatal connections by the expansive process in the mesencephalon.
    European Journal of Nuclear Medicine 09/2009; 36(12):2092. · 4.53 Impact Factor
  • Revista Española de Medicina Nuclear 02/2009; 28(1):32–33. · 0.89 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: A 61-year-old male patient with microbiological diagnosis of L3-L4 spondylodiscitis and persist pain underwent a 67Ga scintigraphic study to assess the antibiotic treatment response.Pathological uptake foci in vertebral bodies of L2 and L4 were observed in the 67Ga planar scintigraphy. A SPECT low-dose CT of the lumbar spine was performed as part of anatomical correlated protocol, detecting an active spondylodiscitis in L3-L4 and a second uptake foci in L2 that was identify as a Schmorl's node.In this case the SPECT-CT hybrid image allowed us to avoid a false positive diagnosis to by locate and characterize an image with abnormal uptake of 67Ga, improving the test specificity and avoiding a wrong diagnosis.
    Revista Espanola De Medicina Nuclear - REV ESP MED NUCL. 01/2009; 28(6):288-290.
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    ABSTRACT: Evaluate the indication for bone scanning during staging of early breast cancer in the light of scientific evidence to assess the need to modify practices with scant effectiveness. The bone scans carried out in our Nuclear Medicine Department in 2007 on patients with primary breast cancer were reviewed retrospectively. Results were analyzed in relation to the clinical and histopathologic findings for each tumor. Bone scan results of tumors >2 cm y <or=5 cm (T2) were analyzed in two groups stratified by tumor size, <or=3 cm or >3 cm, and pre-treatment clinical stage. Out of 245 bone scans of patients with breast cancer, 237 (97%) were negative for metastatic disease and 8 (3%) were positive. Lesions <2 cm (Tis and T1) were diagnosed in 131 patients (53.5%), none of which had bone metastasis at time of diagnosis. Lesions >2 cm and <or=5 cm (T2) were diagnosed in 84 patients (34%), of which 3.6% had bone metastasis. There were no differences in the rate of bone metastases in patients with stage T2 disease and lesions <or=3 cm vs. >3 cm. The bone scan findings did not modify staging in any of the 66 patients with T2 tumors stage IIA, but it did modify staging in 2 of 12 patients with stage IIB tumors. Twenty percent of 15 patients with T3 tumors and 13% of patients with T4 tumors had bone metastasis at time of diagnosis. Ineffective practices should be modified and bone scanning should not be indicated in patients with early breast cancer Tis, T1 and T2 with tumor <or=2 cm, clinical stage IIA. Pre-treatment bone scanning is still indicated in T2 IIB, T3 and T4 disease.
    Revista Española de Medicina Nuclear 01/2009; 28(6):273-7. · 0.89 Impact Factor
  • Revista Española de Medicina Nuclear 28(1):32-3. · 0.89 Impact Factor