Publications (3)5.06 Total impact
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Article: The reproductive effects in rats after chronic oral exposure to low-dose depleted uranium.
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ABSTRACT: This two-generation study evaluated the effects of depleted uranium (DU) on reproduction in rats. Across two generations, Wistar rats (30/sex/group) were maintained on feed containing DU at dose levels of 0 (control group), 4 (DU₄ group), or 40 (DU₄₀ group) mg kg⁻¹ day⁻¹ for 4 months prior to mating. After 4 months of exposure, the pregnancy rate, normal labour rate, and survival rate of offspring produced by F₁ rats were all significantly decreased as compared to the control group, and especially in the DU₄₀ group, these parameters fell by half to two-thirds, while no adverse effects were evident in F₀ rats. The uranium content in the testes and ovaries of F₁ rats in the DU₄ and DU₄₀ groups was significantly higher than that found in F₀ rats. The levels of sex hormone in the serum were disorder in both generations. The enzymes related to spermiogenesis were also significantly different between generations, and the damage was more severe in F₁ rats. In conclusion, the reproductive effects in F₀ rats were slight after chronic oral exposure to DU, while the effects were obvious in F₁ rats.Journal of Radiation Research 06/2012; 53(3):377-84. · 1.68 Impact Factor -
Article: RETRACTED ARTICLE: Reproductive toxicity and pathomorphological changes in rats after chronic oral exposure to low-dose depleted uranium.
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ABSTRACT: This two-generation study evaluated the effects of depleted uranium (DU) on reproductive toxicity in male and female rats. Across two generations, Wistar rats (48/sex/group) were maintained on feed containing DU at dose levels of 0 (control), 4, or 40 mg kg(-1) day(-1) for 4 months prior to mating. Compared with the control group, the pregnancy rate, normal labor rate, and survival rate of offspring produced by F(1) rats were all significantly decreased in the DU groups, while no adverse effects of DU on reproductive parameters were evident at any dose in F(0) rats. The uranium content in the testes and ovaries of the F(1) rats in both DU groups was significantly higher than that found in F(0) rats. The sex hormones and enzyme-related spermiogenesis were also significantly different between generations. With regard to pathomorphological changes in the testes, the sperm displayed atypical changes, including thickening of the anachromasis nucleolus, which appeared more severe in F(1) rats. In conclusion, the reproductive toxicity in F(0) rats was not significant after chronic oral exposure to DU, while toxicity effects were obvious in the F(1) generation at both doses.Biophysik 01/2011; · 1.70 Impact Factor -
Article: A study assessing the genotoxicity in rats after chronic oral exposure to a low dose of depleted uranium.
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ABSTRACT: The aim of this study was to evaluate the potential genotoxicity induced by chronic oral exposure to depleted uranium (DU). Weanling Wistar rats (F(0)), 50/sex/group, were exposed to DU in food at doses of 0, 4, or 40 mg kg(-1)day(-1) for four months. They were subsequently mated, resulting in the birth of F(1) rats. Fifty F(l) weanlings/sex/group were exposed for four months to the same dose levels as their parents. After four months, the uranium content in the tissues, the potential damage to the genetic material, and pathomorphological changes of the testicles were observed in both F(0) and F(1) rats. The genotoxicity of DU was evaluated by the following methods: sperm abnormality assessment, the bone-marrow micronucleus test, and the comet assay. Uranium content in F(1) rats was significantly higher than that in F(0) rats in both the kidney and ovary (p < 0.05). The sperm abnormality rate, marrow cell micronuclei rate, comet tail length, and tailed cell percentage increased in each treatment group in each generation compared with the control group (p < 0.05). When comparing F(1) with F(0) rats, significant differences were detected for most of the indicators, with F(1) rats always exhibiting more damage (p < 0.05). With regard to pathomorphological changes in the testicles, the sperm displayed atypical changes, including thickening of the anachromasis nucleolus, which seemed to be more severe in F(1) rats. Genotoxicity may be induced in rats after chronic oral exposure to a low dose of DU.Journal of Radiation Research 10/2009; 50(6):521-8. · 1.68 Impact Factor
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2009–2012
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The Third Military Medical University
Chongqing, Chongqing Shi, China
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