Li Sun

Wenzhou Medical College, Yung-chia, Zhejiang Sheng, China

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Publications (4)7.45 Total impact

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    ABSTRACT: To investigate the prevalence of dry eye disease (DED) and distribution of associated risk factors among a hospital-based population.
    Eye & contact lens. 09/2014;
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    ABSTRACT: OBJECTIVE: To evaluate the efficacy of silicone punctual plug for treating aqueous tear deficiency dry eye patients. METHODS: Prospective consecutive cases study. Silicone punctal plugs (France Chirurgie Instrumentation) were inserted into lower canaliculus in 65 tear deficiency dry eye patients (65 eyes). The clinical data collected included sex and age of the patients, frequency of lubricant use, the Ocular Surface Disease Index (OSDI) scores, slit lamp microscope examination, Schirmer I test (SIT) (with anesthesia), tear break-up time (TBUT), and ocular surface staining with fluoresce in sodium. All examinations were recorded at baseline, 6 weeks and 6 months after punctal occlusion. RESULTS: There were 41 women and 24 men in this study, and their average age was 41.77 years old. The dry eye symptoms improved in 57 (87.69%) of 65 eyes at 6 months follow-up. The frequency of lubricant use was significantly decreased in these eyes (χ(2) = 81.97, P < 0.01). More importantly, the symptoms disappeared in 25 (38.46%) eyes, which did not need lubricant any more. At baseline, 6 weeks and 6 months after punctal occlusion, OSDI mean score was 37.32 ± 2.41, 19.60 ± 8.07 and 18.17 ± 7.93, respectively (F = 344.10, P < 0.01); mean SIT result was (3.03 ± 0.75) mm, (6.66 ± 2.10) mm and (6.75 ± 2.16) mm, respectively (F = 169.59, P < 0.01); mean TBUT was (2.91 ± 0.76) s, (7.02 ± 2.39) s and (7.57 ± 2.38) s, respectively (F = 242.00, P < 0.01). Compared with the baseline data, hyperemia of conjunctiva grading and ocular surface staining scores were also improved significantly after plug insertion, and all of these differences were statistically significant. Foreign body sensation was the most common complication in our study (12 eyes, 18.46%). Epiphora (4 eyes, 6.15%), partial extrusion (3 eyes, 4.62%), and total extrusion (3 eyes, 4.62%) were the other complications encountered. CONCLUSION: Silicone punctal plug insertion is a stable, effective and safety method for the treatment of tear deficiency dry eye.
    [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 02/2013; 49(2):151-154.
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    ABSTRACT: To determine whether deep anterior lamellar keratoplasty (DALK) using acellular glycerol-cryopreserved corneal tissue (GCCT) could prevent allograft rejection in high-risk corneas. Prospective, randomized, comparative study. The Eye Hospital, Wenzhou Medical College, Zhejiang, China. All patients with herpes simplex virus keratitis, bacterial keratitis, fungal keratitis, or ocular burn, who were eligible as per study design, were invited to participate. According to randomized block design, all patients received either GCCT or fresh corneal tissue (FCT) during DALK. Best-corrected visual acuity (BCVA), slit-lamp microscopy, and in vivo confocal microscopy examinations at 1 week and 1, 3, 6, 12, and 24 months after surgery were analyzed. Kaplan-Meier survival analysis was used to evaluate graft survival rate. Therapeutic success, 2-year rejection-free graft survival rate and 2-year graft survival rate, in vivo confocal microscopy results, BCVA, and endothelial cell density. Postoperative BCVA of 20/40 or better at the last follow-up visit was achieved in 57.6% (19/33) of eyes in the GCCT group and in 54.8% (17/31) of the FCT group. No graft rejection occurred in the GCCT group, while in the FCT group 10 episodes of stromal rejection developed in 7 eyes. Overall, the rejection-free graft survival rate at 2 years was significantly higher in the GCCT group as compared with the FCT group (100.0%, 78.8% respectively, P = .006). Deep anterior lamellar keratoplasty using acellular glycerol-preserved cornea could prevent allograft rejection and promote graft survival rate in high-risk corneas.
    American Journal of Ophthalmology 07/2011; 152(5):762-70.e3. · 4.02 Impact Factor
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    ABSTRACT: To compare the microstructural differences in fresh corneal tissue (FCT) with glycerin-cryopreserved corneal tissue (GCCT) used during deep anterior lamellar keratoplasty (DALK). The medical records of 48 consecutive patients who underwent DALK for stromal opacity without endothelial abnormalities were retrospectively reviewed. Patients were divided into two groups: an FCT group (n = 22) and a GCCT group (n = 26), according to the corneal tissue used. The best corrected visual acuity (BCVA), slit lamp, corneal topography, pachymetry, and laser scanning in vivo confocal microscopy examinations at 2 weeks and 1, 3, 6, 12, and 24 months after surgery were analyzed. No graft rejection developed in the GCCT group, whereas stromal rejection developed in one eye in the FCT group. There were no significant differences in spherical equivalent (P = 0.37), astigmatism (P = 0.26), BCVA (P = 0.64), central corneal thickness (P = 0.73), or endothelial cell density (P = 0.49) between the two groups at 24 months. Confocal microscopy showed that GCCT was acellular, whereas dendritelike cells and keratocytes were found in the FCT group 2 weeks after surgery. The keratocyte density improved significantly in the GCCT group at 3 months after surgery, whereas it decreased significantly after surgery in the FCT group during follow-up. No significant difference in regeneration of nerve fibers was found in the subbasal layer and anterior stroma between the two groups at 24 months. DALK using GCCT provides clinical results comparable to FCT. GCCT can be used safely and effectively for DALK and may minimize stromal rejection after surgery.
    Investigative ophthalmology & visual science 10/2009; 51(2):775-81. · 3.43 Impact Factor

Publication Stats

17 Citations
7.45 Total Impact Points

Institutions

  • 2013
    • Wenzhou Medical College
      Yung-chia, Zhejiang Sheng, China