Yukiko Ishii

Tokyo Woman's Christian University, Edo, Tōkyō, Japan

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Publications (3)38.74 Total impact

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    ABSTRACT: To investigate the potential use of Prussian blue-coated magnetic nanoparticles, termed "Prussian blueberry", to bring about the magnetic elimination of cesium. Prussian blueberry were prepared by a layer-by-layer assembly method. The morphology, structure and physical properties of the Prussian blueberry were investigated as was their ability to magnetically eliminate cesium. We confirmed that Prussian blueberry were composed of a magnetite nanoparticle-core and a Prussian blue-shell. Under a magnetic field, Prussian blueberry (5 mg) reduced the cesium concentration of seawater (3 ml) from 150 ppm to about 50 ppm; but regular Prussian blue could not magnetically eliminate cesium. Moreover, Prussian blueberry removed a similar proportion of cesium from a larger volume of seawater, and from fetal bovine serum and cow's milk. Under a magnetic field, Prussian blueberry was able to rapidly eliminate cesium from seawater and from biological matrices such as serum and milk.
    Pharmaceutical Research 12/2011; 29(5):1404-18. · 4.74 Impact Factor
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    ABSTRACT: Perceptual asymmetries for tasks involving aesthetic preference or line bisection can be affected by asymmetrical neurological mechanisms or left/right reading habits. This study investigated the relative contribution of these mechanisms in 100 readers of Japanese and English. Participants made aesthetic judgments between pairs of mirror-reversed pictures showing: (a) static objects, (b) moving objects and (c) landscapes. A line bisection task was also administered. There was a strong effect of reading direction for static and mobile objects whereby Japanese readers preferred objects with a right-to-left directionality (and vice versa for English readers). In contrast, similar patterns were observed for the Japanese and English readers for the landscape and line bisection tasks. The results show that reading habits affect aesthetic judgments for static and moving object tasks, but not the landscape and line bisection tasks. The difference between the tasks may be related to the horizontal/vertical geometry of the stimuli, which makes the landscape and line bisection tasks more prone to universal effects related to cerebral dominance.
    Brain and Cognition 01/2011; 75(3):242-7. · 2.82 Impact Factor
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    ABSTRACT: Cancer gene therapy requires a safe and effective gene delivery system. Polymer- and lipid-coated magnetic nanocrystals have been used to deliver silencing RNA, but synthesizing these magnetic vectors is difficult. Here, we show that a new nanoparticle formulation can be magnetically guided to deliver and silence genes in cells and tumours in mice. This formulation, termed LipoMag, consists of an oleic acid-coated magnetic nanocrystal core and a cationic lipid shell. When compared with the commercially available PolyMag formulation, LipoMag displayed more efficient gene silencing in 9 of 13 cell lines, and better anti-tumour effects when systemically administered to mice bearing gastric tumours. By delivering an optimized sequence of a silencing RNA that targets the epidermal growth factor receptor of tumour vessels, the intended therapeutic benefit was achieved with no evident adverse immune reaction or untoward side effects.
    Nature Nanotechnology 10/2009; 4(9):598-606. · 31.17 Impact Factor