Aleksandra Seńko

Publications of Aleksandra Seńko

• Assessment of selected serum inflammatory markers of acute phase response and their correlations with adrenal androgens and metabolic syndrome in a population of men over the age of 40.

  Authors: Waldemar Herman, Aleksandra Seńko, Izabela Korczowska, Katarzyna Lącka

  Polskie archiwum medycyny wewnetrznej. 11/2009; 119(11):704-711.

  INTRODUCTION: Inflammatory mechanisms and decreasing adrenal androgen production are involved in the pathogenesis of numerous age-related diseases. OBJECTIVES: The aim of our study was to assessINTRODUCTION: Inflammatory mechanisms and decreasing adrenal androgen production are involved in the pathogenesis of numerous age-related diseases. OBJECTIVES: The aim of our study was to assess selected negative (transferrin) and positive (alpha1-antichymotrypsin [alpha1-ACT], C-reactive protein [CRP]) acute phase proteins, and to investigate associations between these proteins and serum dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) levels, as well as anthropometrical and biochemical indices of metabolic syndrome (MS) in men over 40 years of age. PATIENTS AND METHODS: In 271 randomly selected men aged 40 to 80 years and living in the province of Lubuskie, Poland, transferrin, alpha1-ACT, CRP, and adrenal androgens were measured and features of metabolic syndrome were evaluated. RESULTS: Age is strongly correlated with acute phase proteins in men: positively for CRP and alpha1-ACT (r = 0.216, P <0.001 and r = 0.193, P <0.05, respectively) and negatively for transferrin (r = -0.268, P <0.0001). CRP revealed a negative correlation with DHEA (r = -0.248, P <0.05), although not with DHEA-S. There were no correlations between alpha1-ACT, transferrin, and adrenal androgens. As opposed to adrenal androgens, serum CRP and transferrin (but not alpha1-ACT) levels are associated with metabolic syndrome (MS) in men over 40 years of age (P <0.001). CONCLUSIONS: A prognostic test using systemic markers of general inflammation (especially CRP) may help (as opposed to DHEA and DHEA-S) identify men over 40 years of age who suffer from MS.

• [Could serum DHEA and DHEAS levels be good risk predictors of metabolic syndrome and osteoporosis in the population of ageing men?]

  Authors: Waldemar Adam Herman, Aleksandra Seńko, Izabela Korczowska, Katarzyna Łacka

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. 09/2009; 27(159):197-201.

  The occurrence of metabolic syndrome (MS) and osteoporosis is essentials danger for public health. It seems that one of epidemiological factors of those diseases is age-depending adrenal androgensThe occurrence of metabolic syndrome (MS) and osteoporosis is essentials danger for public health. It seems that one of epidemiological factors of those diseases is age-depending adrenal androgens deficiency. AIM OF THE STUDY: was to evaluate relationships between DHEA/DHEAS serum levels and BMD along with frequency of MS in ageing Caucasian men. MATERIALS AND METHODS: In 271 randomly chosen men aged 40 to 80 years living in Lubuskie district (Poland) adrenal androgens, anthropometrical indices in addition to densitometry were estimated. RESULTS: DHEA/DHEAS serum levels showed positive correlation with BMD (r = 0.16 and r = 0.18, respectively, p < 0.001). Statistic essential dependencies between decreased adrenal androgens and coexistence of neoplastic diseases (p < 0.001), hypertension (p < 0.05), peripheral perfusion disturbances (p < 0.005) and dementia (p < 0.0001) were also observed. CONCLUSIONS: The evaluation of DHEA/DHEAS serum level is useful in estimation of general health status of ageing men, but does not identify participants suffering from metabolic syndrome.