Publications (2)0 Total impact
Article: Assessment of bone status in inhaled corticosteroid user asthmatic patients with an ultrasound measurement method.[show abstract] [hide abstract]
ABSTRACT: BACKGROUND: The effect of inhaled corticosteroid (ICS) on the bone status of asthmatic patients is still uncertain, because it can differ by race and because there have been few cases in Japan. In this study, the bone status of ICS users with asthma was evaluated in an actual clinical setting in Japan. METHODS: In 7 participating hospitals, ICS users with asthma and control subjects were age- and gender-matched and recruited into this study. To assess bone status, ultrasound measurements of each individual's calcaneus were made using an AOS-100. The ratio of the osteo sono-assessment index (OSI) to the average OSI corrected for age and gender was denoted as %OSI and used for quantitative assessment. The second %OSI measurement was performed 6 months after the first %OSI one. During the study period, individual treatment remained unchanged. Results: There were no significant differences in the 1st and 2nd %OSI between the ICS users and control subjects. However, the 2nd %OSI significantly decreased compared with 1st %OSI in female ICS users, although there were no significant changes in the male and female control subjects and male ICS users. Conclusions: The 6 month management of asthma in the actual clinical setting, including regular ICS use, might have a harmful influence on the bone status of female asthmatic patients. It may be necessary to manage and treat female patients for potent corticosteroid-induced osteoporosis, although further analyses of bone status in asthma patient ICS users will be required.Allergology International 06/2011; 60(4):459-65.
Article: [Effect of proactive use of inhaled procaterol on dyspnea in daily activities and quality of life in patients with chronic obstructive pulmonary disease].[show abstract] [hide abstract]
ABSTRACT: To examine the effects of inhaled procaterol (Meptin Air : MA), a short-acting beta2-agonist, for proactive use rather than rescue use in dyspnea and health-related quality of life in patients with chronic obstructive pulmonary disease (COPD), who complained of dyspnea in daily activities despite treatment with long-acting bronchodilators. Patients with moderate to most severe COPD who were on maintenance therapy with tiotropium and other long-acting bronchodilators were studied. Severity of dyspnea was evaluated with the Shortness of Breath Questionnaire (SOBQ) and patients were recommended to use MA on an as-needed basis before daily activities which had caused dyspnea. The effects of MA were evaluated with the St. George's Respiratory Questionnaire (SGRQ) and MRC dyspnea scale. Baseline and post-administrative lung functions and exercise capacity (6-minute walking test) were measured. SOBQ revealed that all patients still had dyspnea in daily activities despite maintenance therapy. Inhalation of MA to prevent dyspnea in daily activities on an as-needed basis significantly improved QOL in SGRQ, lung function and MRC scales. Six-minute walking distances showed a tendency to improve. Proactive use of MA as needed (assist use) improved QOL and continuing dyspnea despite maintenance drugs. Assist use of MA before effort improved exercise capacity, suggesting that it might improve the ability of activity of daily living (ADL).Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society. 09/2009; 47(9):772-80.