Yasutake Tomata

Tohoku University, Miyagi, Japan

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Publications (30)76.78 Total impact

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    ABSTRACT: Population-based researches indicate that circulating adiponectin is inversely associated with muscle strength. However, interpretation of the findings has been limited by the use of a cross-sectional design. This study aimed to examine the prospective relationship between baseline circulating adiponectin concentration and change in muscular function-related physical performance in older adults. A 1-year prospective cohort study of Japanese community-dwelling elderly was conducted between 2002 and 2003. Four hundred thirty-four older persons participated in the measurements of physical function, including leg extension power, functional reach, timed up-and-go test, and 10-m maximum walking speed, at baseline and follow-up. After adjustment for potential covariates, higher serum adiponectin concentration was found to be significantly associated with poorer physical performance at baseline (leg extension power [watt], P < 0.001; functional reach [cm], P < 0.001; log timed up-and-go test, P = 0.007; log 10-m maximum walking speed, P < 0.001). The results of the prospective analysis by analysis of covariance indicated that the elderly with higher serum adiponectin concentrations (tertiles) at baseline tended to have a decreased performance in leg extension power (means [95% confidence interval]: lowest, -105 [-125, -85.7]; middle, -117 [-135, -97.8]; highest, -140 [-160, -120], watt, P for trend = 0.021) and timed up-and-go test (lowest, -0.08 [-0.28, -0.12]; middle, -0.10 [-0.29, 0.10]; highest, 0.28 [0.07, 0.48], s, P for trend = 0.019), but not two other functioning. High circulating adiponectin concentration may be an indicator of decreased physical performance, especially muscle strength, in older adults. Copyright © 2015 Elsevier B.V. All rights reserved.
    Nutrition Metabolism and Cardiovascular Diseases 03/2015; DOI:10.1016/j.numecd.2015.03.010 · 3.88 Impact Factor
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    ABSTRACT: AimThe aim of the present ecological study was to evaluate the relationship between the rate of participation in Secondary Preventive Services (SPS) and the incidence of disability in Japanese municipalities.Methods We used the national statistics data for Long-term Care Insurance (LTCI), because all Japanese people aged ≥65 years are eligible for LTCI services depending on their functional status assessed by a national uniform standard in all municipalities. The disability incidence rate for the 2-year period in 2009–2010 was compared among five different levels of SPS participation in 2006–2008. The primary outcome was the sum total disability incidence rate in LTCI from 2009 to 2010. The outcome was divided according to disability level into three patterns: “all levels (Support Level 1 – Care Level 5)”, “mild disability (Care Level ≤1)” and “moderate to severe disability (Care Level ≥2)”.ResultsThere was a significant inverse association between the SPS participation rate and disability incidence rate. Among 1541 municipalities, those in the highest SPS participation rate quintile (≥9.79 per 1000 elderly population) had a lower disability incidence rate for all levels than those in the lowest quintile (<1.86 per 1000 elderly population; absolute rate difference 0.6%; age-adjusted incident rate ratio 0.94; 95% CI 0.89–0.99). This inverse association was observed for mild disability and not for moderate to severe disability.Conclusions Municipalities with a higher SPS participation rate have a lower incidence rate of mild disability. SPS could be an effective health policy for containing mild disability incidence among the elderly. Geriatr Gerontol Int 2015; ●●: ●●–●●.
    Geriatrics & Gerontology International 02/2015; DOI:10.1111/ggi.12440 · 1.58 Impact Factor
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    ABSTRACT: Objectives Interventions that promote physical activity to prevent psychological distress and disuse syndromes were carried out in disaster-stricken areas. However, the effect of these interventions to promote physical activity in disaster-stricken areas has not yet been fully clarified. The purpose of this study was to examine the health effects of promoting physical activity in a disaster-stricken area.Methods We conducted an exercise intervention as part of a health survey project among residents of Ishinomaki-city, Miyagi, Japan in 2012. To determine if changes in health condition differed between intervention participants and nonparticipants, health condition data from 81 participants were compared with data from 81 nonparticipants selected by propensity score matching. Factors including sex, age, original address (pre-quake), and six outcome variables (psychological distress [K6 score], subjective health status, sleep duration, sleep quality, frequency of outings, and time spent walking) were used for matching. A linear mixed model was used for statistical analysis.Results There were no significant differences in K6 score between participants and nonparticipants (P=0.913). Significant improvements were observed in subjective health status (P=0.011) and outing frequency (P=0.002), but not in other outcome variables.Conclusion Subjective health status and outing frequency were significantly improved among participants of the exercise intervention. Exercise intervention may be an effective public health strategy in disaster-stricken areas.
    [Nippon kōshū eisei zasshi] Japanese journal of public health 01/2015; 62(2):66-72. DOI:10.11236/jph.62.2_66
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    ABSTRACT: To evaluate dietary patterns in relation to colorectal cancer risk in Japanese. We prospectively assessed the association between dietary patterns among the Japanese and the risk of colorectal cancer. Dietary information was collected from 44,097 Japanese men and women aged 40-79 years without a history of cancer at the baseline in 1994. During 11 years of follow-up, we documented 854 cases of colorectal cancer, which included 554 cases of colon cancer and 323 cases of rectal cancer. Factor analysis (principal component analysis) based on a validated food frequency questionnaire identified three dietary patterns: (1) a Japanese dietary pattern, (2) an "animal food" dietary pattern, and (3) a high-dairy, high-fruit-and-vegetable, low-alcohol (DFA) dietary pattern. After adjustment for potential confounders, the DFA pattern was inversely associated with the risk of colorectal cancer (hazard ratio of the highest quartile vs the lowest, 0.76; 95 % confidence interval 0.60-0.97; p for trend = 0.02). When colon and rectal cancers were separated, the inverse association between the DFA pattern and cancer risk was observed for rectal cancer (p for trend = 0.003), but not for colon cancer (p for trend = 0.43). No apparent association was observed for either the Japanese dietary pattern or the "animal food" dietary pattern. The DFA dietary pattern was found to be inversely associated with the risk of colorectal cancer. This association was observed for rectal cancer, but not for colon cancer.
    Cancer Causes and Control 03/2014; 25(6). DOI:10.1007/s10552-014-0375-5 · 2.96 Impact Factor
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    ABSTRACT: To examine the hypothesis that disability prevalence has increased to a greater degree in the areas severely affected by the earthquake and tsunami of 11 March 2011 than in other areas. Longitudinal analysis using public statistics data from the Ministry of Health, Labour and Welfare in Japan. The analysis included 1549 municipalities covered by the Long-term Care Insurance (LTCI) system. 'Disaster areas' were defined as three prefectures (Iwate, Miyagi, Fukushima). The outcome measure was the number of aged people (≥65 years) with LTCI disability certification. Rates of change in disability prevalence from February 2011 to February 2012 were used as the primary outcome variable, and were compared by analysis of covariance between 'Coastal disaster areas', 'Inland disaster areas' and 'Non-disaster areas'. Regarding disability prevalence at all levels, the mean value of the increase rate in Coastal disaster areas (7.1%) was higher than in Inland disaster areas (3.7%) and Non-disaster areas (2.8%) (p<0.001). The areas that were severely affected by the earthquake and tsunami had a significantly higher increase in disability prevalence during the 1 year after the earthquake disaster than other areas.
    Journal of epidemiology and community health 02/2014; 68(6). DOI:10.1136/jech-2013-203541 · 3.29 Impact Factor
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    ABSTRACT: Objectives An earlier study using the data from the Japanese Long-term Care Insurance (LTCI) system reported a scenario for achieving the target of Health Japan 21 (the second term): future gains in health expectancy from 2011 to 2020 must be larger than gains in expectancy. According to this scenario (the Healthy Life Expectancy Extension Scenario), the proportion of disability (cases≥Care Level 2 in LTCI disability certification) will gradually decrease by 1% per year from 2011. The purpose of this study was to estimate the cost savings in long-term care and medical care if the Healthy Life Expectancy Extension Scenario is achieved.Methods We used data from Japanese national statistics and a survey conducted in Osaki city, Miyagi. The natural course of disability cases (≥Care Level 2) was estimated under the assumption that the future population composition would be equal to the population projections for Japan and the future proportion of disabilities for each age grade would be equal to that of 2010. Then, the decrease in the number of disabilities based on the Healthy Life Expectancy Extension Scenario was calculated. Finally, the cost savings in long-term care and medical care associated with the assumed decrease in the number of disability cases was calculated.Results When the disability cases (≥Care Level 2) were shifted to "no disability certification (not requiring care)," a total estimated cost reduction of 5,291 billion yen was achieved from 2011 to 2020. Furthermore, a total estimated reduction of 2,491 billion yen was achieved for the same period when all disability shifts to "Care Level 1" were accounted for.Conclusion As a rough calculation, if the Health Japan 21 (second term) target is achieved, approximately 2,500-5,300 billion yen will be saved in the cost of long-term care and medical care.
  • 01/2014; 72(2):84-90. DOI:10.5264/eiyogakuzashi.72.84
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    ABSTRACT: To examine the relationship between changes in time spent walking since middle age and incident functional disability. In 2006, we conducted a prospective cohort study of 7,177 disability-free Japanese individuals aged ≥65years lived in Ohsaki City, Miyagi Prefecture, Japan. Participants were categorized into four groups according to changes in time spent walking based on two questionnaire surveys conducted in 1994 and in 2006. Incident functional disability was retrieved from the public Long-term Care Insurance database, and the subjects were followed up for 5years. The Cox proportional hazards model was used to investigate the association between changes in time spent walking and the risk of incident functional disability. Compared with subjects who remained sedentary, the multivariate-adjusted hazard ratios (95% confidence intervals) were 0.69 (0.49-0.98) among those who became active and 0.64 (0.50-0.82) among those who remained active. These results did not alter when analyses were stratified by gender, age and motor function status. An increase in time spent walking among sedentary adults is significantly associated with a lower risk of incident functional disability.
    Preventive Medicine 11/2013; 59. DOI:10.1016/j.ypmed.2013.11.019 · 2.93 Impact Factor
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    ABSTRACT: To date, little is known about the association between dietary pattern and disability in older adults. The present prospective cohort study investigated the association between dietary patterns and incident functional disability. Information on food consumption and other lifestyle factors was collected from Japanese older persons aged ≥65 years via a questionnaire. Three dietary patterns (Japanese pattern, animal food pattern, and high dairy pattern) were derived using principal component analysis of the consumption of 39 food and beverage items. Data on functional disability were retrieved from the public Long-term Care Insurance database, in which participants were followed up for 5 years. The Cox model was used to estimate the multivariate-adjusted hazard ratios of incident functional disability. Among 14,260 participants, the 5-year incidence of functional disability was 16.6%. The Japanese pattern score was associated with a lower risk of incident functional disability (hazard ratio of the highest quartile vs the lowest, 0.77; 95% confidence interval: 0.68-0.88; p trend <.001). An animal food pattern and a high dairy pattern tended to have a higher risk of incident functional disability, but not to a significant degree. In Japanese older persons, the Japanese dietary pattern is associated with a decreased risk of incident functional disability.
    The Journals of Gerontology Series A Biological Sciences and Medical Sciences 11/2013; 69(7). DOI:10.1093/gerona/glt182 · 4.98 Impact Factor
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    ABSTRACT: Background: Epidemiological evidence regarding the effect of coffee on the incidence of prostate cancer is inconsistent. We aimed to investigate coffee consumption and the risk of prostate cancer risk in a general Japanese population. Methods: We conducted a prospective cohort study in Ohsaki city, Japan, where 18 853 men aged 40–79 years participated in a baseline survey. Coffee consumption was assessed via a validated self-administered questionnaire. During 11 years of follow-up (from January 1 1995 to December 31, 2005), 318 incident cases of prostate cancer were detected. The Cox proportional hazards regression model was used to calculate the hazard ratios (HRs) and 95% confidence interval (CIs). Results: There was a significant inverse association between coffee consumption and the incidence risk of prostate cancer. Compared with those who did not drink coffee, the multivariate adjusted HRs were 0.81 (95% CI: 0.61–1.07), 0.73 (95% CI: 0.53–1.00), and 0.63 (095% CI: 0.39–1.00) for those who drank coffee occasionally, 1–2 cups per day, and ⩾3 cups per day, respectively, with a P for trend of 0.02. Conclusion: This prospective finding from a Japanese population adds evidence that coffee intake is inversely associated with the incidence of prostate cancer.
    British Journal of Cancer 05/2013; 108(11). DOI:10.1038/bjc.2013.238 · 4.82 Impact Factor
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    ABSTRACT: OBJECTIVES: To assess whether oral care (tooth brushing, regular dental visits, and use of dentures) affects mortality in elderly individuals with tooth loss. DESIGN: A 4-year prospective cohort study. SETTING: Ohsaki City, Japan. PARTICIPANTS: Twenty-one thousand seven hundred thirty community-dwelling individuals aged 65 and older. MEASUREMENTS: In a baseline survey in 2006, data were collected on number of remaining teeth and oral care status as measures of dental health. Data were also collected on age, sex, education level, smoking, alcohol drinking, time spent walking daily, medical history, psychological distress, and energy and protein intake as covariates. During the 4-year follow-up between 2006 and 2010, information on mortality was obtained from Ohsaki City government. RESULTS: The multivariate-adjusted Cox proportional hazards model showed an inverse dose-response relationship between number of remaining teeth and mortality (P for trend <.001). In participants with 0 to 19 teeth, practicing oral care was inversely associated with mortality. The multivariate hazard ratio for mortality in participants who practiced all three types of oral care was 0.54 (95% confidence interval = 0.45-0.64), compared with participants who practiced none of the three. CONCLUSION: Tooth brushing, regular dental visits, and use of dentures are inversely associated with mortality in elderly individuals with tooth loss.
    Journal of the American Geriatrics Society 04/2013; 61(5). DOI:10.1111/jgs.12225 · 4.22 Impact Factor
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    ABSTRACT: Although breastfeeding is associated with a reduction in the risk for breast cancer, its relationship with another hormone-related female cancer, endometrial cancer, has not been fully investigated. The objective of the present study was to prospectively examine the association between lactation pattern and the risk for incidence of breast cancer and endometrial cancer in Japanese women. We analyzed data for 26 680 women registered in the Ohsaki National Health Insurance Cohort Study, who were 40-79 years old at the baseline. During the 11 years of follow-up, we identified 148 incident cases of breast cancer and 32 incident cases of endometrial cancer. Compared with breastfeeding only, multivariate hazard ratios and 95% confidence intervals for the risk of breast cancer incidence were 1.12 (0.92-1.37) for women who had performed mixed feeding and 1.80 (1.14-2.86) for those who fed their babies only with formula (P-trend=0.014). For endometrial cancer incidence, multivariate hazard ratios and 95% confidence intervals were 1.32 (0.86-2.03) for women who had performed mixed feeding and 3.26 (1.23-8.61) for those who had performed only formula feeding (P-trend=0.018). Our findings appear to raise the possibility that nonbreastfeeding is positively associated with the risks for both breast cancer incidence and endometrial cancer incidence. Confirmation of our findings would require further investigation.
    European journal of cancer prevention: the official journal of the European Cancer Prevention Organisation (ECP) 03/2013; 22(2):187-92. DOI:10.1097/CEJ.0b013e3283564610 · 2.76 Impact Factor
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    ABSTRACT: BACKGROUND: Patients with physical disease are known to suffer considerable psychological distress. Social support may confound the association between physical disease and psychological distress. Population-based epidemiological studies have not been conducted on the association between history of physical disease, psychological distress and social support. METHODS: Using cross-sectional data from 2006, we studied 43 487 community-dwelling people aged ≥40 years living in Japan. We examined the association between 13 self-reported histories of physical disease and psychological distress evaluated using the Kessler 6-item psychological distress scale (K6), defined as ≥13 points out of 24. To investigate the association, we performed multiple logistic regression analyses adjusted for age, gender, social support and possible confounders. Social support, as the interaction between physical disease and psychological depression, was tested through the addition of cross-product terms to the multivariate-adjusted model. RESULTS: The following histories of physical disease were found significantly and positively associated with psychological distress: cancer, diabetes mellitus, hyperlipidemia, hypertension, myocardial infarction, stroke, gastric or duodenal ulcer, liver disease, arthritis, osteoporosis, kidney disease and fall or fracture (odds ratio, 1.2-2.3). Social support did not modify the association between most histories of physical disease and psychological distress. CONCLUSIONS: Subjects with a history of physical disease were significantly and positively associated with psychological distress, and social support did not modify this association for most physical diseases. Even after patients have left hospital following treatment for physical disease, they require continuous monitoring for psychological distress by doctors and paramedics.
    The European Journal of Public Health 02/2013; 24(1). DOI:10.1093/eurpub/ckt017 · 2.46 Impact Factor
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    ABSTRACT: Objectives We attempted to predict health expectancy in Japan for the period between 2011 and 2020, considering the target of Health Japan 21 (the second term) that future gains in health expectancy be larger than in life expectancy.Methods We used data from Japanese national statistics. Health expectancy between 2011 and 2020 was predicted using the Sullivan method under the assumption that future mortality was equal to the estimate in Population Projections for Japan (January 2012), and under three scenarios of future prevalence of bad health status.Results The numbers of expected years without activity limitation at birth for males and females in 2020 were predicted as 71.2 and 74.3, respectively, under the scenario that prevalence of activity limitation was constant since 2010; 71.4 and 74.5 under the scenario that the prevalence followed the recent trend; and 71.7 and 74.9 under the scenario that the prevalence decreased with such a rate that future gains in health expectancy were equal to in life expectancy. The rate of decrease in the prevalence in 2010-2020 in the last scenario was estimated to be 0.95 in males and 0.96 in females. The numbers of expected years with subjective well-being at birth in 2020 predicted under above three scenarios were between 69.5 and 71.2 in males and between 72.9 and 74.6 in females. The rate of decrease in the last scenario was estimated to be 0.96 in males and 0.97 in females. The numbers of expected years without care needs at age 65 in 2020 predicted under above three scenarios were between 18.0-18.2 in males and between 21.2-21.5 in females. The rate of decrease in the last scenario was estimated to be 0.90 in males and 0.91 in females.Conclusion The health expectancy in 2011-2020 was predicted under some scenarios of future prevalence of bad health status. The rate of decrease in the future prevalence of bad health status was estimated with a view to the accomplishment of the target of Health Japan 21 (the second term).
    [Nippon kōshū eisei zasshi] Japanese journal of public health 01/2013; 60(12):738-44.
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    ABSTRACT: Objectives The purpose of this study was to examine the relationship between serum total cholesterol levels and certification eligibility for long-term care insurance in elderly Japanese individuals.Methods The Tsurugaya Project was a comprehensive geriatric assessment conducted for community-dwelling elderly individuals aged ≥70 years in the Tsurugaya area, Sendai, Japan. Of the 2,925 inhabitants, 958 subjects participated in the Tsurugaya Project. For this analysis, we used 827 subjects who gave informed consent and were not qualified for long-term care insurance at the time of the baseline survey. Subjects were followed up for 6 years. We classified the subjects into 4 quintiles and used the fourth quintile (212-230 mg/dL) as a reference for statistical analysis. We used Cox proportional hazards model to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of certification eligibility for long-term care insurance according to total cholesterol levels in serum.Results During 6 years of follow-up, a total of 214 subjects were qualified for long-term care insurance certification. The lowest serum total cholesterol level (<177 mg/dL) was significantly associated with increased eligibility for long-term care insurance certification. Compared with the fourth quintile, multivariate HRs (95%CIs) of long-term care insurance certification were 1.91 (1.23-2.98), 1.36 (0.85-2.18), 0.99 (0.62-1.56), 1.38 (0.88-2.17), for <177 mg/dL, 177-194 mg/dL, 195-211 mg/dL, and ≤231 mg/dL, respectively. Moreover, the association was statistically significant even after excluding subjects with a history of liver disease or cancer, an abnormality in the liver function test, or high levels of high-sensitivity C-reactive protein.Conclusion Low serum total cholesterol levels were significantly associated with increased eligibility for long-term care insurance certification even after adjusting for a variety of confounding factors.
    [Nippon kōshū eisei zasshi] Japanese journal of public health 01/2013; 60(8):435-443.
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    ABSTRACT: Objective: The purpose of this study was to examine the effectiveness of the Functional Improvement Program of the Musculoskeletal System among users of Preventive Care Service under Long-Term Care Insurance. Methods: A total of 3,073 subjects were analyzed. We used the prediction formula to estimate the predicted value of the Kihon Checklist after one year, and calculated the measured value minus the predicted value. The subjects were divided into two groups according to the measured value minus predicted value tertiles: the lowest and middle tertile (good-to-fair measured value) and the highest tertile (poor measured value). We used a multiple logistic regression model to calculate the odds ratio (OR) and 95% confidence interval (CI) of the good-to-fair measured values of the Kihon Checklist after one year, according to the Functional Improvement Program of the Musculoskeletal System. Results: In potentially dependent elderly, the multivariate adjusted ORs (95% CI) of the good-to-fair measured values were 2.4 (1.3-4.4) for those who attended the program eight times or more in a month (vs those who attended it three times or less in a month), 1.3 (1.0-1.8) for those who engaged in strength training using machines (vs those who did not train), and 1.4 (1.0-1.9) for those who engaged in endurance training. Conclusions: In this study, among potentially dependent elderly, those who attended the program eight times or more in a month and those who engaged in strength training using machines or endurance training showed a significant improvement of their functional capacity.
    Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) 01/2013; 68(1):11-21. DOI:10.1265/jjh.68.11
  • 01/2013; 71(6):357-366. DOI:10.5264/eiyogakuzashi.71.357
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    ABSTRACT: Background: It is unclear whether weight change since young adulthood affects the risk of mortality due to cardiovascular disease (CVD). The aim of this study was to investigate weight change since age 20 in relation to the risk of CVD mortality. Methods and Results: A total of 41,364 eligible Japanese men and women aged 40-79 years participated in the Ohsaki Cohort Study baseline survey in 1994. Hazard ratios (HRs) and 95% confidence intervals (CIs) for CVD mortality were calculated according to weight change since age 20 (loss ≥10.0kg; loss 5.0-9.9kg; stable [±4.9 kg]; gain 5.0-9.9kg; gain ≥10.0kg). During 13.3 years of follow-up, 1,756 participants died of CVD. The association between weight change and CVD mortality was L-shaped in men and U-shaped in women; the multivariate HR (95% CI) for men with weight loss ≥10.0kg was 1.52 (1.25-1.85), and that for women with weight loss ≥10.0kg and weight gain ≥10.0kg was 1.62 (1.25-2.11) and 1.36 (1.09-1.69), respectively. Cross-classification analysis based on body mass index (BMI) at age 20 and weight change tended to be U-shaped, except for men whose BMI had been <25kg/m(2) at age 20, in which case it was L-shaped. Conclusions: Weight loss since young adulthood is associated with excess risk of mortality due to CVD in men, while a U-shaped relationship was observed for women.
    Circulation Journal 12/2012; 77(3). DOI:10.1253/circj.CJ-12-0745 · 3.69 Impact Factor
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    ABSTRACT: BACKGROUND: Although previous studies showed the long-term effects of sleep duration on risk of weight gain, Western tends to gain weight irrespective of sleep duration over a long period. Conversely, it is showed that body mass index (BMI) decreases during a long period in Japanese and thus, the long-term effect of sleep duration on weight gain and obesity is still unclear in Asia. METHODS: We followed up 13,629 participants aged 40-79years and prospectively collected data from 1995 to 2006. We divided the participants into five groups according to their self-reported sleep duration: ⩽5h (short sleep), 6h, 7h (reference), 8h, and ⩾9h (long sleep). The main outcome was ⩾5kg weight gain or BMI⩾25kg/m(2) (obesity). We used logistic regression analyses to derive odds ratios (ORs) and 95% confidence intervals (CIs), adjusted for several confounding factors. RESULTS: We observed no association between sleep duration and risk of ⩾5kg weight gain and obesity. After stratification by BMI, long sleepers had a significantly increased risk of ⩾5kg weight gain (OR: 1.36, 95%CI: 1.09-1.70) in obese participants. CONCLUSIONS: Among community-dwelling Japanese, only obese long sleepers have a significantly increased long-term risk of ⩾5kg weight gain.
    Sleep Medicine 12/2012; 14(2). DOI:10.1016/j.sleep.2012.09.024 · 3.10 Impact Factor
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    ABSTRACT: BACKGROUND: The longer healthy life expectancy observed in Japan may be partly attributed to the Japanese diet. The researchers sought to examine whether serum isoflavone levels are associated with disability and death. METHODS: The researchers used a nested case-control study to compare serum isoflavones (daidzein, genistein, glycitein, and equol) levels between 165 participants that died or were certificated as disabled (cases) and 177 controls. Disability was defined by certification of long-term care insurance. Conditional logistic regression models were used to calculate the risk of isoflavones for the composite outcome. RESULTS: The proportion of cases was lower in the group with the highest levels of equol (34/91, 37%) compared with equol nonproducers (84/161, 52%). The risk of disability or death among equol producers remained reduced after adjusting for age and sex (odds ratio: 0.55, 95% confidence interval: 0.33-0.93). In a multivariate model, this risk was also unchanged (odds ratio: 0.51, 95% confidence interval: 0.27-0.96). There were no significant associations between daidzein, genistein, and glycitein with the composite endpoint. CONCLUSIONS: Higher serum equol levels, but not any other isoflavones, were inversely associated with the composite endpoint of disability and death. Although it cannot be concluded that equol per se has preventive effects on disability or death, higher equol levels appear associated with better health.
    The Journals of Gerontology Series A Biological Sciences and Medical Sciences 10/2012; DOI:10.1093/gerona/gls198 · 4.98 Impact Factor