[Show abstract][Hide abstract] ABSTRACT: 10.1093/nar/gku1193 INFRAFRONTIER––providing mutant mouse resources as research tools for the international scientific community INFRAFRONTIER Consortium *, ABSTRACT The laboratory mouse is a key model organism to in-vestigate mechanism and therapeutics of human dis-ease. The number of targeted genetic mouse models of disease is growing rapidly due to high-throughput production strategies employed by the International Mouse Phenotyping Consortium (IMPC) and the de-velopment of new, more efficient genome engineer-ing techniques such as CRISPR based systems. We have previously described the European Mouse Mu-tant Archive (EMMA) resource and how this inter-national infrastructure provides archiving and dis-tribution worldwide for mutant mouse strains. EMMA has since evolved into INFRAFRONTIER (http://www. infrafrontier.eu), the pan-European research infras-tructure for the systemic phenotyping, archiving and distribution of mouse disease models. Here we de-scribe new features including improved search for mouse strains, support for new embryonic stem cell resources, access to training materials via a compre-hensive knowledgebase and the promotion of inno-vative analytical and diagnostic techniques.
Nucleic Acids Research 11/2014; · 8.81 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: The laboratory mouse is the premier animal model for studying human disease and thousands of mutants have been identified or produced, most recently through gene-specific mutagenesis approaches. High throughput strategies by the International Knockout Mouse Consortium (IKMC) are producing mutants for all protein coding genes. Generating a knock-out line involves huge monetary and time costs so capture of both the data describing each mutant alongside archiving of the line for distribution to future researchers is critical. The European Mouse Mutant Archive (EMMA) is a leading international network infrastructure for archiving and worldwide provision of mouse mutant strains. It operates in collaboration with the other members of the Federation of International Mouse Resources (FIMRe), EMMA being the European component. Additionally EMMA is one of four repositories involved in the IKMC, and therefore the current figure of 1700 archived lines will rise markedly. The EMMA database gathers and curates extensive data on each line and presents it through a user-friendly website. A BioMart interface allows advanced searching including integrated querying with other resources e.g. Ensembl. Other resources are able to display EMMA data by accessing our Distributed Annotation System server. EMMA database access is publicly available at http://www.emmanet.org.