Fei-Hong Bing

Tianjin University of Traditional Chinese Medicine, T’ien-ching-shih, Tianjin Shi, China

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Publications (3)6.55 Total impact

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    ABSTRACT: The effects of homonojirimycin (HNJ), one of alkaloids from Commelina communis L., on protection against influenza virus infection in mice were investigated. HNJ was found to improve the survival rate, prolong the mean survival time and reduce virus yields in lungs on days 4 and 6 post-infection (p.i.), after the agent had been orally administered to the mice from 2 days before infection to 6 days p.i. Administration of HNJ (1mg/kg) significantly increased interferon (IFN)-γ and interleukin (IL)-10 levels but decreased tumor necrosis factor (TNF)-α and IL-6 levels in serum and lungs of influenza-infected mice on days 2, 4 or 6 p.i. These results showed that HNJ exerted protection against influenza virus infection and produced effective immune responses in vivo.
    Phytomedicine: international journal of phytotherapy and phytopharmacology 06/2013; · 2.97 Impact Factor
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    ABSTRACT: Whether administration of total alkaloids from Commelina communis L. (TAC) reduces lung damage in influenza virus-infected mice was investigated. Compared with untreated mice, significantly less severe damage was found in the lungs of mice administered TAC at 8 mg/kg per day for 6 days. TAC significantly decreased viral loads in the lungs. The concentrations of IFN-γ in the serum of TAC-treated mice were significantly lower than those of virus control mice at 4 and 6 days post-infection. The results indicate that TAC imparted partial protection to the mice by reducing pulmonary viral loads and limiting lesions in the lungs.
    Microbiology and Immunology 12/2010; 54(12):754-7. · 1.55 Impact Factor
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    ABSTRACT: The antiviral activity of total alkaloids from Commelina communis L. (TAC) against influenza virus A/PR/8/34 (H1N1) was investigated in vitro and in vivo. TAC exhibited an inhibitory action on the growth of influenza virus in Madin-Darby canine kidney cells when added before or after viral infection. In mice infected with influenza virus, orally administered TAC at 8, 16 or 32 mg/kg per day for 6 days significantly increased the survival rate, prolonged the mean survival time and reduced the viral titers in the lung and the lung index, compared with that of the untreated virus control. The results obtained suggest that TAC has a pronounced protective effect against infection by influenza A virus.
    Archives of Virology 09/2009; 154(11):1837-40. · 2.03 Impact Factor

Publication Stats

5 Citations
6.55 Total Impact Points

Institutions

  • 2013
    • Tianjin University of Traditional Chinese Medicine
      T’ien-ching-shih, Tianjin Shi, China
  • 2010
    • Hubei University of Chinese Medicine
      Shih-yen, Hubei, China
  • 2009
    • Gansu College of Traditional Chinese Medicine
      Kan-shui, Chongqing Shi, China