Haruo Nishijima

Publications (14)59.12 Total impact

• Article: Drebrin immunoreactivity in the striatum of a rat model of levodopa-induced dyskinesia.

  Haruo Nishijima, Akira Arai, Tamaki Kimura, Fumiaki Mori, Junko Yamada, Keisuke Migita, Koichi Wakabayashi, Masayuki Baba, Shinya Ueno, Masahiko Tomiyama
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  ABSTRACT: Levodopa-induced dyskinesia has been suggested to result from maladaptive plasticity at corticostriatal synapses. Synaptic plasticity is based upon morphologic changes of dendritic spines. To elucidate whether the morphologic changes of spines occur in the striatum of rat models of levodopa-induced dyskinesia, we examined immunoreactivity of drebrin, an actin-binding protein localized in dendritic spines of excitatory synapses, using 6-hydroxydopamine-lesioned rats repeatedly treated with levodopa. The cross-sectional area of drebrin-immunoreactive organelles, putative spines, in the dopamine-denervated striatum of the levodopa-induced dyskinesia model was greater than that of the Parkinson's disease model. Immunoelectron microscopic examinations confirmed that drebrin-immunoreactive spines became enlarged in the dopamine-denervated striatum of the levodopa-induced dyskinesia model, but not in the Parkinson's disease model. These results suggest that the development of levodopa-induced dyskinesia is associated with enlargement of dendritic spines at corticostriatal excitatory synapses.
  Neuropathology 12/2012; · 2.02 Impact Factor
• Article: A family with IVIg-responsive Charcot-Marie-Tooth disease.

  Yasuo Miki, Masahiko Tomiyama, Rie Haga, Haruo Nishijima, Chieko Suzuki, Aiichiro Kurihara, Kazuhiro Sugimoto, Akihiro Hashiguchi, Hiroshi Takashima, Masayuki Baba
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  ABSTRACT: We report a family of intravenous immunoglobulin (IVIg)-responsive X-linked Charcot-Marie-Tooth disease Type 1 (CMT1X) with a novel gap junction protein 1 mutation. Two of three siblings in the family complained of subacute motor and sensory impairment, and their symptoms improved after the administration of IVIg. Additional IVIg treatment also resulted in similar improvement. The other also showed a mild improvement on IVIg. It has been suggested that an immune-mediated process is involved in the progression of neuropathy in CMT1X. The finding in our report provides evidence of susceptibility to immune-mediated demyelinating neuropathy in some form of CMT1X. Superimposed demyelinating neuropathy as well as a gradual deterioration of neuropathy over decades can be a clinical manifestation of CMT1X.
  Journal of Neurology 12/2012; · 3.47 Impact Factor
• Article: Fatal subarachnoid hemorrhage caused by Aspergillus arteritis without angiographic abnormalities.

  Yasuo Miki, Masahiko Tomiyama, Rie Haga, Haruo Nishijima, Chieko Suzuki, Michiharu Nishijima, Hiroshi Midorikawa, Seiya Sannohe, Hidekachi Kurotaki, Koichi Wakabayashi, Masayuki Baba
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  ABSTRACT: No source of bleeding is detected by angiogram in 15-20% of patients with nonaneurysmal subarachnoid hemorrhage (SAH). This negative angiographic finding might suggest a benign prognosis. We describe a case of fatal SAH caused by Aspergillus arteritis without formation of fusiform dilatation or aneurysms. A 76-year-old man with a 2-month history of progressive visual loss due to pachymeningitis around the optic nerves suffered from SAH in the bilateral sylvian fissures. Repetitive serum galactomannan assay and angiography showed no abnormality. Post mortem examination revealed marked proliferation of Aspergillus in the granulomas of the frontal base dura mater. In addition, major trunks and several branches of the bilateral middle cerebral arteries were invaded by Aspergillus hyphae, which destroyed the walls in the absence of dilatation and aneurysms. Invasive aspergillosis of the CNS often forms a mycotic aneurysm. However, four autopsy cases of nonaneurysmal SAH due to invasive aspergillosis have been reported. The present case is the second autopsy case of Aspergillus arteritis without angiographic abnormality, resulting in fatal SAH. Aggressive and continuous antifungal therapy is absolutely necessary in suspected cases of invasive aspergillosis of the CNS, even if angiography is negative and therapeutic markers of aspergillosis are normal.
  Neuropathology 01/2012; 32(5):566-9. · 2.02 Impact Factor
• Article: Amyotrophic lateral sclerosis with demyelinating neuropathy.

  Haruo Nishijima, Masahiko Tomiyama, Chieko Suzuki, Tomoya Kon, Yukihisa Funamizu, Tatsuya Ueno, Rie Haga, Yasuo Miki, Akira Arai, Tamaki Kimura, Fumiaki Mori, Koichi Wakabayashi, Masayuki Baba
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  ABSTRACT: Amyotrophic lateral sclerosis (ALS) with demyelinating polyneuropathy is a rare condition. We describe two ALS patients with demyelinating neuropathy. Immunomodulatory therapies brought slight symptomatic benefits to the patients, but the treatments could not halt the progression of ALS. Chance coincidence of the two diseases is unlikely in view of the low prevalence. ALS, mainly consisting of progressive axonal degeneration, might show temporal demyelinating features of peripheral nerves both electrophysiologically and pathologically. The pathomechanism for the demyelination in ALS remains to be elucidated.
  Internal Medicine 01/2012; 51(14):1917-21. · 0.94 Impact Factor
• Article: Radicular myoclonus in a patient with Guillain-Barré Syndrome.

  Yasuo Miki, Masahiko Tomiyama, Tatsuya Ueno, Rie Haga, Haruo Nishijima, Akira Arai, Chieko Suzuki, Jin-Ichi Nunomura, Masayuki Baba
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  ABSTRACT: A 53-year-old Japanese woman presented with myoclonus during the course of Guillain-Barré syndrome. The myoclonus was characterized by relatively regular involuntary movements, starting from proximal muscles of the right lower leg, and moving almost simultaneously towards the left lower leg and upper trunk. Surface electromyography revealed rhythmic synchronous discharges with 100-200 ms duration in the agonist and antagonist muscles at approximately 4 Hz. The jerk-locked back averaging, long latency reflexes, and somatosensory evoked potentials studies were normal. We report myoclonus due to radiculitis in a patient with Guillain-Barré syndrome.
  Internal Medicine 01/2012; 51(15):2021-3. · 0.94 Impact Factor
• Source

  Available from: Haruo Shimazaki

  Article: Novel compound heterozygous mutations of the SACS gene in autosomal recessive spastic ataxia of Charlevoix-Saguenay.

  Rie Haga, Yasuo Miki, Yukihisa Funamizu, Tomoya Kon, Chieko Suzuki, Tatsuya Ueno, Haruo Nishijima, Akira Arai, Masahiko Tomiyama, Haruo Shimazaki, Yoshihisa Takiyama, Masayuki Baba
  Clinical neurology and neurosurgery 12/2011; 114(6):746-7. · 1.30 Impact Factor
• Article: Fever of unknown origin.

  Chieko Suzuki, Tatsuya Ueno, Haruo Nishijima, Rie Haga, Yasuo Miki, Akira Arai, Masahiko Tomiyama, Masayuki Baba
  The Lancet 11/2011; 378(9804):1756. · 38.28 Impact Factor
• Article: Status epilepticus associated with extensive axonal swelling in the unilateral cerebral cortex and hippocampus.

  F Mori, K Tanji, Y Miki, H Nishijima, M Baba, H Kurotaki, K Wakabayashi
  Neuropathology and Applied Neurobiology 10/2011; 38(4):387-90. · 3.80 Impact Factor
• Article: Taste impairment in Guillain-Barré syndrome: more frequent than thought?

  Haruo Nishijima, Masahiko Tomiyama, Chieko Suzuki, Tomoya Kon, Yukihisa Funamizu, Tatsuya Ueno, Rie Haga, Yasuo Miki, Akira Arai, Masayuki Baba, Tamaki Kimura
  Journal of the Peripheral Nervous System 09/2011; 16(3):270-1. · 2.80 Impact Factor
• Article: POEMS syndrome with a giant pancreas cyst.

  Yasuo Miki, Masahiko Tomiyama, Tatsuya Ueno, Rie Haga, Haruo Nishijima, Akira Arai, Chieko Suzuki, Mitsuomi Kaimori, Masayuki Baba
  Neurological Sciences 08/2011; 32(5):987-8. · 1.32 Impact Factor
• Article: Ulnar Nerve Palsy-like Motor and Sensory Loss Caused by A Small Cortical Infarct.

  Tatsuya Ueno, Masahiko Tomiyama, Rie Haga, Haruo Nishijima, Tomoya Kon, Yukihisa Funamizu, Yasuo Miki, Akira Arai, Chieko Suzuki, Masayuki Baba
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  ABSTRACT: A 56-year-old man with a small infarct in the left precentral knob area induced both motor and sensory impairments that were similar to right ulnar nerve palsy. The only difference from ulnar nerve palsy was that the patient showed sensory disturbance not only on the ulnar side but also on the radial side of the right ring finger.
  Journal of stroke and cerebrovascular diseases: the official journal of National Stroke Association 03/2011;
• Article: Clinical availability of skin biopsy in the diagnosis of Parkinson's disease.

  Yasuo Miki, Masahiko Tomiyama, Tatsuya Ueno, Rie Haga, Haruo Nishijima, Chieko Suzuki, Fumiaki Mori, Mitsuomi Kaimori, Masayuki Baba, Koichi Wakabayashi
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  ABSTRACT: To determine whether skin biopsy is practically useful in the premortem diagnosis for Parkinson's disease (PD), we examined Lewy pathology in the skin of the chest wall and leg, obtained from 6-mm punch biopsies, using phosphorylated alpha-synuclein antibody in 20 patients with clinically diagnosed PD. Abnormal accumulation of alpha-synuclein was found in the chest skin of two (10%) of 20 patients, but not in the leg. Although skin biopsy combined with a conventional immunohistochemistry for alpha-synuclein is not sufficient as a diagnostic tool, we could firstly demonstrate Lewy pathology in premortem tissue. The skin remains to be a promising tissue to be examined for the premortem diagnosis of PD.
  Neuroscience Letters 12/2009; 469(3):357-9. · 2.11 Impact Factor
• Article: [A case of posttraumatic forehead cavernous angioma].

  Haruo Nishijima, Shinjitsu Nishimura, Yuichi Furuno, Mitsuomi Kaimori, Michiharu Nishijima
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  ABSTRACT: Cavernous angiomas of the bone are rare tumors. Skull cavernomas are even less frequent. Most cavernous angiomas of the bone are congenital tumors. In a review of the literature, we found only one case report of de novo generation of a skull cavernous angioma. We present a case of a 25-year-old woman who had experienced a head injury, and 7 years later exhibited a skull tumor at the exact region of the injury. We performed tumor resection and cranioplasty. Follow-up examinations revealed no recurrence or neurological defects. Pathological findings showed a cavernous angioma-like lesion with some atypical details. We finally diagnosed the lesion as a de novo cavernous angioma. Our case suggests that fine injury may result in de novo generation of bone cavernomas.
  No shinkei geka. Neurological surgery 09/2009; 37(9):899-904. · 0.13 Impact Factor
• Article: Venous cerebral infarction in a patient with peripheral hemodialysis shunt and occlusion of the left brachiocephalic vein.

  Haruo Nishijima, Masahiko Tomiyama, Rie Haga, Tatsuya Ueno, Yasuo Miki, Akira Arai, Tamaki Kimura, Chieko Suzuki, Jin-ichi Nunomura, Shinya Kakehata, Toshiaki Kawaguchi, Masayuki Baba
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  ABSTRACT: Intracranial venous congestion is a rare condition in hemodialysis patients with central venous occlusion. We report a patient with cerebral venous infarction resulting from high reflex flow into the cranium induced by an arteriovenous hemodialysis shunt in the arm and occlusion of the brachiocephalic vein. This case illustrates that abnormal extracranial venous circulation should be considered when cerebral venous congestion is assumed to produce neurologic symptoms in patients with an arteriovenous shunt.
  Journal of stroke and cerebrovascular diseases: the official journal of National Stroke Association 20(4):381-3.