Yong Zhang

Publications (3)0 Total impact

• Article: [Expressions of microtubule-associated protein 2 and nestin in the development of human embryo and fetal tongue muscles].

  Xue-Hong Liu, Yong Zhang
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  ABSTRACT: To explore the role of microtubule-associated protein 2 (MAP-2) and nestin in the development of tongue muscles of human embryos and fetuses. PV immunohistochemistry was used to detect the expressions of MAP-2 and nestin proteins in the tongue tissues of human embryos and fetuses at the second, third and fourth months of gestation. MAP-2 and nestin positivity was detected in the tongue muscles of human embryos at 2 to 4 months of gestation. In the embryos at the second month of gestation, no obvious MAP-2 positive cells were found in the tongue muscles; at 3 and 4 months, the number of MAP-2-positive cells in the tongue muscles was 24.14∓8.28 and 15.86∓3.89, with the expression intensity of 109.42∓11.62 and 124.27∓8.73, respectively. At 2, 3 and 4 months of gestation, the number of nestin-positive cells in the tongue muscles was 12.50∓3.17, 19.00∓7.63, and 22.80∓6.91, with expression intensity of 119.99∓24.02, 102.20∓11.76, and 98.24∓10.66, respectively. As the gestational age increased, the number of MAP-2-positive cell number continued to decline following a transient increase but the expression intensity kept increasing; nestin-positive cells increased continuously but the expression intensity kept decreasing in the embryonic or fetal tongue muscles. MAP-2 and nestin proteins are involved in the regulation of the development of tongue muscles in human embryos and fetuses.
  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 01/2013; 33(1):135-7.
• Article: [Microtubule-associated protein 2 and nestin expressions in human embryonic and fetal gastric tissues].

  Xue-Hong Liu, Yong Zhang
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  ABSTRACT: OBJEVTIVE: To investigate the role of microtubule-associated protein 2 (MAP-2) and nestin in gastric development in human embryos and fetuses. Immunohistochemistry was used to detect the expressions of MAP-2 and nestin proteins in the gastric cardia, pyloric and gastric tissues of human embryos and fetuses during the second, third and fourth month of development. In the second to fourth months of gestation, MAP-2 and nestin expressions were detected in the neural cells and neural fibers of the intermuscular nerve plexus and submucosal plexus in the gastric cardia, pyloric and gastric tissues. As the gestational age increased, the number of MAP-2- and nestin-positive cells and the expression intensity all increased in the myenteric plexus, but MAP-2 and nestin expressions were negative in the glandular and mucosal tissues of human embryonic and fetal gastric cardia, pylorus or gastric walls. MAP-2 and nestin participate in the regulation of the development of gastric tissues in human embryos.
  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 09/2012; 32(9):1328-31.
• Article: [Expression of nNOS, Pax3 and Cx43 proteins in early developing posterior horn of embryonic and fetal human spinal cord].

  Yong Zhang, Xue-hong Liu
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  ABSTRACT: To investigate the distribution pattern of the expressions neuronal nitric oxide synthase (nNOS), Pax3 and connexin 43 (Cx43) proteins in the early developing posterior horn of embryonic and fetal human spinal cord. Immunohistochemistry was used to detect the expressions of nNOS, Pax3 and Cx43 proteins in the posterior horn of the spinal cord during the second, third and fourth month of human embryonic and fetal development. In the second to fourth month of gestation, the expressions of nNOS and Pax3 proteins increased gradually from weak expression to strong expression in the posterior horn of the spinal cord. In the second to third month of development, Cx43 protein expression was negative in the posterior horn of the spinal cord, but positive in the myelin sheath. In the fourth month, positive Cx43 expression was detected in some of the cells in the posterior horn of the spinal cord. nNOS, Pax3 and Cx43 proteins are closely related to the growth and development of the spinal cord in human embryos and fetuses.
  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 09/2009; 29(8):1651-3.