ABSTRACT: The patient was a 74-year-old woman who was diagnosed with advanced breast cancer, T4aN0M0, stage IV. She was placed on chemotherapy of weekly paclitaxel (PTX) (60 mg/m(2) day 1, 8, 15 with 1 course consisting of 28 days). We used dexamethasone (8 mg/body) as premedication for chemotherapy every time. Three courses were performed with no severe adverse reaction. On the fourth course, day 8, she complained of nausea, vomiting, paroxysmal cough and fecal incontinence after a few minutes of dexamethasone administration. Her blood pressure dropped to a minimum of 64 mmHg (systolic pressure) and she soon became drowsy. We diagnosed the anaphylaxis-like reaction for dexamethasone, immediately discontinued dexamethasone infusion, and treated her successfully. Forty minutes after the episode had occurred, she recovered. The few reports on anaphylaxis or anaphylaxis-like reaction to dexamethasone must be taken into account when we use these drugs.
Gan to kagaku ryoho. Cancer & chemotherapy 09/2009; 36(8):1383-5.
ABSTRACT: We examined administration methods of adenovirus vector carrying human insulin gene (AxCAIns), which could safely and effectively enhance liver regeneration in diabetic rats after hepatectomy.
Male Wistar rats were made diabetic with streptozotocin and subjected to 70% partial hepatectomy. AxCAIns was administrated into the spleen, the portal vein, the peritoneal cavity, or the femoral muscle. Liver regeneration and damage, and nutritional conditions were compared among the groups which were different in the administration methods of AxCAIns.
Intrasplenic administration of AxCAIns enhanced liver regeneration, improving nutritional conditions without liver damage. In contrast, intraportal administration enhanced liver regeneration but caused hypoglycemia with liver damage. Neither intraperitoneal nor intramuscular administration produced detectable serum levels of human c-peptide, and did not enhance liver regeneration.
In conclusion, data showed that intrasplenic administration of AxCAIns, rather than other methods, effectively enhanced liver regeneration without liver damage and improved nutritional conditions after hepatectomy in diabetic rats. It is suggested that insulin gene transfer with AxCAIns via the spleen may safely and effectively improve posthepatectomized conditions in inslinopenic patients.
Journal of Surgical Research 04/2003; 110(1):228-34. · 2.25 Impact Factor
ABSTRACT: Gastrointestinal stromal tumor (GIST) in the distal third of the rectum was detected in a 57-year-old man who underwent an
abdominoperineal resection of the rectum. Because the tumor expressed CD34 and c-kit gene product, but did not express smooth muscle actin or S-100 protein, it was diagnosed as an uncommitted type of GIST.
Moreover, a specific mutation in the sequence coding the juxtamembrane domain in exon 11 of the c-kit proto-oncogene was revealed by a polymerase chain reaction-single-strand conformation polymorphism method. One year after
resection, the patient developed multiple liver metastases. It is suggested that a specific mutation in exon 11 of the c-kit proto-oncogene may have played an essential role in the development of the liver metastases.
Journal of Gastroenterology 09/2000; 35(10):779-783. · 4.16 Impact Factor
ABSTRACT: A case of inflammatory pseudotumor of the spleen is described in a 63-year-old woman who presented with an intrasplenic tumor
and an elevated serum level of soluble interleukin 2 receptor (sIL-2R). Microscopic examination after removal of the spleen
revealed that the tumor was composed of mixed cellular infiltrates, mainly lymphocytes and plasma cells, and spindle-cell
proliferation. Epstein-Barr virus (EBV) was specifically detected in the tumor by in situ hybridization for EBV RNA. The serum
level of sIL-2R level was normalized after splenectomy. EBV infection may play a role in the development of splenic inflammatory
pseudotumor and the elevation of sIL-2R level.
Journal of Gastroenterology 06/2000; 35(7):563-566. · 4.16 Impact Factor