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Publications (4)3.36 Total impact

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    ABSTRACT: Both calcium and vitamin D play important roles in cardiac muscle contraction and performance. In this cross-sectional study, we evaluated the status of serum calcium, PTH and 25(OH)D(3) and their correlation with left ventricular Function and NYHA Functional class in 95 heart failure patients referred to Shahid Chamran Hospital, Isfahan, Iran, by colorimetric, immunoradiometric, and Immunochemiluminescent assays, echocardiography and interview respectively. The study was performed between Oct 2007 and Feb 2008. Twenty eight women and 67 men of functional classes 1, 2, or 3 participated in the study. Mean (SD) of age of the participants was 62(11) years. Mean (SD) serum calcium and 25(OH)D(3) were 2.41(0.16) mmol/L and 56.78(51.33) nmol/L, respectively. The overall prevalence of low vitamin D status was 84.2%. There was no correlation between serum calcium and 25(OH)D(3) with LVEF. Interestingly, patients with hyperparathyroidism (serum PTH>65 ng/L) had lower LVEF (27% versus 32.5% p = 0.03). NYHA functional class was worse in patients with hyperparathyroidism (p = 0.08). Hypovitaminosis D is very prevalent in heart failure patients. Hyperparathyroidism in these patients may adversely affect cardiac function. Vitamin D3 might serve as an adjunctive treatment for heart failure patients.
    Biological trace element research 08/2009; 135(1-3):67-73. · 1.92 Impact Factor
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    ABSTRACT: Abstract Cryptosporidium is one of the most common causes of diarrhea in the world, which can be severe and prolonged in immunocompromised patients. We compared the prevalence rate of Cryptosporidium infection in hemodialysis patients and 2 control groups (i.e., their healthy family members and normal population). Stool specimens of 104 adult outpatient chronic hemodialysis patients, their 91 healthy family members, and 140 healthy individuals were examined for the presence of Cryptosporidium oocysts by using a modified acid-fast staining method. Twelve (11.5%) dialysis patients were infected with Cryptosporidium. This was significantly higher than 4 (4.4%), and 5 (3.6%) cases in the 2 control groups, respectively (p Keywords: Cryptosporidium; hemodialysis; parasite; renal failure Document Type: Research Article DOI: http://dx.doi.org/10.1111/j.1542-4758.2006.00133.x Affiliations: 1: Nephrology and 2: Parasitology, Isfahan University of Medical Sciences, Isfahan, Iran; 3: Division of Nephrology, Saint Louis University School of Medicine, Saint Louis, Missouri, U.S.A. Publication date: October 1, 2006 $(document).ready(function() { var shortdescription = $(".originaldescription").text().replace(/\\&/g, '&').replace(/\\, '<').replace(/\\>/g, '>').replace(/\\t/g, ' ').replace(/\\n/g, ''); if (shortdescription.length > 350){ shortdescription = "" + shortdescription.substring(0,250) + "... more"; } $(".descriptionitem").prepend(shortdescription); $(".shortdescription a").click(function() { $(".shortdescription").hide(); $(".originaldescription").slideDown(); return false; }); }); Related content In this: publication By this: publisher In this Subject: Urology By this author: SEYRAFIAN, Shiva ; PESTEHCHIAN, Nader ; KERDEGARI, Maryam ; YOUSEFI, Hossein Ali ; BASTANI, Bahar GA_googleFillSlot("Horizontal_banner_bottom");
    Hemodialysis International 01/2006; 10(4). · 1.44 Impact Factor
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    ABSTRACT: Introduction: Cryptosporidium is a parasite from coccidian order and one of the most common causes of diarrhea in the world, which can lead to a severe and prolonged disease in immunodeficient patients. There is a discrepancy regarding the prevalence rate of this parastie in different studies in our country patients on dialysis are usually prone to infectious disease especially those caused by opportunistic organisms. We studied the prevalence rate of the cryptosporidium infection in a group of patients on dialysis who were considered to have acquired immunodeficiency. Methods: This is a descriptive analytic study which included 104 dialyzed patients on dialysis in Al-zahra, shariati and Ali-asghar hospital, Isfahan, Iran. Between January 2001 and October 2001. Cases were chosen according to convenience sampling standards. They were all tested for cryptosporidium infection. Test results in the case group were then compared with the rate of cryptosporidium infection. In the control group which included 91 healthy household family members of the patients in the case group and 140 healthy people from the society. At least two samples were collected from every subject on two different occasions. To detect cryptosporidium oocytes, modified acid-fast technique we used. Results: 12 (11/5%) out of the 104 cases were proved infected by cryptosporidium. This figure dropped to 3.9% in control group respectively. Based on X2 test, rate of infection for the case group was considerably greater than for the control group Infection in the case group didn't show any significant relation with such factors as sex, age and duration of dialysis, history if kidney transplantation and history of immunosuppressive drugs consumption. The rate of infection peaked in diabetic cases (19.4%), while compared with non- diabetic ones (8.3%) (p<0.05). Conclusions: Our study showed that the prevalence rare of cryptosporidium infection in dialyzed patients was considerably higer than general population. The results were fully correspondent with those of other surveys on immunocompromized patients. Neither Our study nor the similar previously conducted ones revealed no significant association between age and sex and cryptosporidium infection. We couldn't show any relation between the rate of infection and duration of dialysis. This difference is likely due to either limited number of cases or a lack of proportional increase in susceptibility to infection atter a certain period of dialysis. Finally we found out that the rate of infection in dialyzed diabetic patients was extra ordinarily higher, which could be the product of acquired immunodeficiency of diabetes.
    Journal of Research in Medical Sciences. 01/2003;
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    ABSTRACT: Background: Hemodialysis (HD) patients are prone to infections as a result of impaired immune system. Early detection of disease helps to prevent complications. The aim of this study was to evaluate the prevalence of intestinal parasite infections in HD patients and compare it with control groups. Methods: In a cross sectional study, the stool sample of 155 HD patients, and 294 controls were examined for parasitic contaminations. Control groups included: 130 patients' family, 16 staffs of three HD wards and 148 normal populations. Three stool samples were taken from each participant. Direct smear of stool were prepared and inspected by trichrome staining. Then, groups were compared with SPSS version12 by Chi-square and T-test methods. Results: 43.9% of 155 HD patients were infected by intestinal parasites. There was 40% parasite infection in non diabetic and 45% in diabetic case groups with no significant difference between the 2 groups (p > 0.05). There was no relation between parasite infection with sex, HD duration and use of immunosuppressive drugs. 43.1% of control group was also infected. No significant difference was seen between the 2 groups (p > 0.05).The most common parasite was Blastocystis hominis in the 2 groups. Conclusion: This study could not show increased parasite infection in HD patients compared to control groups. The high prevalence of intestinal parasites in HD patients and control groups, may indicate that population hygiene status is not well controlled, and emphasizes more health care providers' attention.