Franziska Biedermann

University of Leipzig , Leipzig, Saxony, Germany

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Publications (4)4.55 Total impact

  • Esther K Diekhof · Franziska Biedermann · Rudolf Ruebsamen · Oliver Gruber ·
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    ABSTRACT: Auditory deviancy detection comprises both automatic and voluntary processing. Here, we investigated the neural correlates of different components of the sensory discrimination process using functional magnetic resonance imaging. Subliminal auditory processing of deviant events that were not detected led to activation in left superior temporal gyrus. On the other hand, both correct detection of deviancy and false alarms activated a frontoparietal network of attentional processing and response selection, i.e. this network was activated regardless of the physical presence of deviant events. Finally, activation in the putamen, anterior cingulate and middle temporal cortex depended on factual stimulus representations and occurred only during correct deviancy detection. These results indicate that sensory discrimination may rely on dynamic bottom-up and top-down interactions.
    Brain research 09/2009; 1297(1297):118-23. DOI:10.1016/j.brainres.2009.08.040 · 2.84 Impact Factor
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    ABSTRACT: The extent of perceptual impairment following unilateral lesions in the auditory cortex, its thalamic or callosal afferents was studied with psychoacoustic tests. Thresholds for the discrimination of signal frequency, intensity and duration were acquired under three different conditions of headphone stimulation ('monaural', 'interaural', and 'dichotic signal/noise tests') using the three-alternative forced-choice procedure. The different test alternatives generated distinct auditory percepts, which is in accordance with the assumption of specific signal processing at the level of the auditory brainstem and at thalamocortical auditory areas. Twenty-one patients from neurology were studied who suffered from unilateral lesions in the auditory cortex, the auditory thalamus, or the acoustic radiation. Location and extent of the lesions were assessed by magnetic resonance imaging. Monaural tests of either ear revealed no deficits in auditory performance. The patients showed impaired discrimination of signal frequency, intensity and duration in the dichotic signal/noise tests, when the signals were presented to the ear contralateral and the noise ipsilateral to the lesion. With inverted signal and noise stimulation, however, the thresholds were in the range of age-matched controls. All patients were able to master the interaural tests, which indicates the preserved ability to lateralize sound sources to the left and to the right with either one of the auditory cortices left intact. Another 24 patients were studied who had lesions mostly close to but sparing the before-mentioned auditory structures. All of them showed unimpaired performance in all test alternatives. The results indicate the specificity of the dichotic signal/noise tests for the identification of unilateral lesions in thalamocortical auditory structures. In addition, the results also point to the capacity of each telencephalic hemisphere to process the full range of auditory lateralization from left to right.
    Audiology and Neurotology 02/2008; 13(2):123-44. DOI:10.1159/000111784 · 1.71 Impact Factor
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Publication Stats

36 Citations
4.55 Total Impact Points


  • 2008-2009
    • University of Leipzig
      • • Institute of Biology
      • • Faculty of Biosciences, Pharmacy and Psychology
      Leipzig, Saxony, Germany
  • 2004
    • Max Planck Institute for Human Cognitive and Brain Sciences
      Leipzig, Saxony, Germany