Sapana Vora

Publications (3)10.54 Total impact

• Source

  Available from: Stephen C Kales

  Article: Correction: CBL Is Frequently Altered in Lung Cancers: Its Relationship to Mutations in MET and EGFR Tyrosine Kinases.

  Yi-Hung Carol Tan, Soundararajan Krishnaswamy, Suvobroto Nandi, Rajani Kanteti, Sapana Vora, Kenan Onel, Rifat Hasina, Fang-Yi Lo, Essam El-Hashani, Gustavo Cervantes, Matthew Robinson, Han-Shui Hsu, Stephen C Kales, Stanley Lipkowitz, Theodore Karrison, Martin Sattler, Everett E Vokes, Yi-Ching Wang, Ravi Salgia
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  ABSTRACT: [This corrects the article on p. e8972 in vol. 5.].
  PLoS ONE 01/2011; 6(1). · 4.09 Impact Factor
• Source

  Available from: Stephen C Kales

  Article: CBL is frequently altered in lung cancers: its relationship to mutations in MET and EGFR tyrosine kinases.

  Yi-Hung Carol Tan, Soundararajan Krishnaswamy, Suvobroto Nandi, Rajani Kanteti, Sapana Vora, Kenan Onel, Rifat Hasina, Fang-Yi Lo, Essam El-Hashani, Gustavo Cervantes, Matthew Robinson, Han-Shui Hsu, Stephen C Kales, Stanley Lipkowitz, Theodore Karrison, Martin Sattler, Everett E Vokes, Yi-Ching Wang, Ravi Salgia
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  ABSTRACT: Non-small cell lung cancer (NSCLC) is a heterogeneous group of disorders with a number of genetic and proteomic alterations. c-CBL is an E3 ubiquitin ligase and adaptor molecule important in normal homeostasis and cancer. We determined the genetic variations of c-CBL, relationship to receptor tyrosine kinases (EGFR and MET), and functionality in NSCLC. Using archival formalin-fixed paraffin embedded (FFPE) extracted genomic DNA, we show that c-CBL mutations occur in somatic fashion for lung cancers. c-CBL mutations were not mutually exclusive of MET or EGFR mutations; however they were independent of p53 and KRAS mutations. In normal/tumor pairwise analysis, there was significant loss of heterozygosity (LOH) for the c-CBL locus (22%, n = 8/37) and none of these samples revealed any mutation in the remaining copy of c-CBL. The c-CBL LOH also positively correlated with EGFR and MET mutations observed in the same samples. Using select c-CBL somatic mutations such as S80N/H94Y, Q249E and W802* (obtained from Caucasian, Taiwanese and African-American samples, respectively) transfected in NSCLC cell lines, there was increased cell viability and cell motility. Taking the overall mutation rate of c-CBL to be a combination as somatic missense mutation and LOH, it is clear that c-CBL is highly mutated in lung cancers and may play an essential role in lung tumorigenesis and metastasis.
  PLoS ONE 01/2010; 5(1):e8972. · 4.09 Impact Factor
• Article: Translating genetic questions into clinical answers in acute myeloid leukemia.

  Sapana Vora, Nathan Ellis, Kenan Onel
  Leukemia research 08/2009; 33(11):1448-9. · 2.36 Impact Factor