Publications (3)4.05 Total impact
Article: Serum TSH level in healthy Koreans and the association of TSH with serum lipid concentration and metabolic syndrome.[show abstract] [hide abstract]
ABSTRACT: The proper treatment of subclinical hypothyroidism and the normal range of serum thyroid stimulating hormone (TSH) concentration are intensely debated. However, few reports have investigated TSH concentrations in Asian ethnic groups. Therefore, the present study was designed to define the TSH reference range in a Korean population and to investigate the metabolic significance of TSH concentration. We enrolled patients who underwent medical examination at the CHA Bundang Medical Center. Anthropometric data were evaluated, and serum TSH, free T4, and lipid profiles were assayed. A total of 7,270 subjects were included. Mean TSH concentration of the study population was 1.82 ± 0.95 mU/L, and we observed a sex-related difference in TSH concentration (male, 1.67 ± 0.87 mU/L; female, 2.02 ± 1.01 mU/L; p < 0.01). When the 2.5 and 97.5 percentiles were calculated, 95% TSH reference limits were 0.52-4.29 mU/L. TSH concentration was higher in elderly subjects, during winter, in postmenopausal women, and in obese males. Moreover, TSH showed significantly positive correlations with serum total cholesterol, triglyceride, and low density lipoprotein cholesterol regardless of sex, age, season, obesity, or menopausal status (all p < 0.01). Finally, TSH concentration was positively related to the prevalence of metabolic syndrome. We demonstrated the association between TSH concentration within the normal reference range and serum lipid levels. TSH concentration varies according to sex, age, season, and body mass index (only in males). Moreover, high normal TSH levels were significantly associated with an increased prevalence of metabolic syndrome, which may be of importance when evaluating subjects with high normal TSH concentration.The Korean Journal of Internal Medicine 12/2011; 26(4):432-9.
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ABSTRACT: The roles of body fat and muscle masses for developing cardiometabolic disorders are opposed to each other. The aim of this study was to analyze whether abdominal visceral to thigh muscle thickness ratio (AVTMR) measured by ultrasonography can be a simple yet useful index assessing the disproportion between visceral fat and thigh muscle, and whether it is associated with carotid atherosclerosis. This was an observational study performed on 15 healthy men and 68 men with newly-diagnosed type 2 diabetes. Using ultrasonography, abdominal visceral thickness, mid-thigh muscle thickness and carotid artery intima-media thickness (CA-IMT) were determined. The visceral fat amount and lipid-rich muscle mass were increased and metabolic profile was poorer across AVTMR tertiles. The AVTMR was associated an increased CA-IMT independent of traditional risk factors. The AVTMR measure using ultrasonography might be a relevant index identifying individuals at an increased risk of cardiovascular disease.Ultrasound in medicine & biology 09/2011; 37(9):1444-51. · 2.02 Impact Factor
Article: Regression of the increased common carotid artery-intima media thickness in subclinical hypothyroidism after thyroid hormone replacement.[show abstract] [hide abstract]
ABSTRACT: The association between subclinical hypothyroidism and cardiovascular disease and the beneficial effect of levothyroxine replacement in subclinical hypothyroidism are still under debate. The present study was designed to determine whether subclinical hypothyroidism is associated with an increase in the intima-media thickness of the common carotid artery (C-IMT) and whether thyroid hormone replacement can reverse this change in the C-IMT. Patients with newly-diagnosed subclinical (n=36) and overt (n=40) hypothyroidism and healthy euthyroid individuals (n=32) participated in this study. All the patients were examined for clinical characteristics, and the serum lipid levels and the C-IMT were measured. Patients with subclinical hypothyroidism had a C-IMT measurement after 18 months of levothyroxine replacement. There were meaningful differences in total cholesterol and LDL-cholesterol levels between patients with subclinical hypothyroidism and euthyroidism. The subjects with subclinical and overt hypothyroidism had a greater C-IMT compared with euthyroid controls (0.66+/- 0.10 and 0.70+/- 0.11 vs. 0.57+/- 0.08 mm, respectively; P < 0.05). After 12 months of euthyroidism, 28 of 36 patients with subclinical hypothyroidism completed the follow-up study. Thyroid hormone replacement significantly decreased the C-IMT (0.67+/- 0.11 to 0.60+/- 0.10 mm; P = 0.021) and improved the lipid profile. Based on multiple regression analysis, the decrement in LDL-cholesterol was independently associated with the regression of the C-IMT. Subclinical hypothyroidism was closely related to an increased C-IMT. Thyroid hormone replacement resulted in regression of the increased C-IMT, which was attributed to the improvement in the lipid profile.Endocrine Journal 06/2009; 56(6):753-8. · 2.03 Impact Factor