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Milan A. Nedeljkovic,
Miodrag Ostojic,
Nebojsa Lalic,
Branko Beleslin,
Ivana Nedeljkovic,
Katarina Lalic, Miljko Ristic,
Vojislav Giga,
Lazar Angelkov,
Miloje Tomasevic,
Vladimir Kanjuh
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ABSTRACT: A 55-year-old man, with a history of medically uncontrolled coronary vasospasm, presented for evaluation of chest pain 6 months
after implantation of left internal mammary artery. Due to recurrent episodes of vasospastic angina and serious complications
of coronary spasm (ventricular fibrillation, myocardial infarction), a stent had previously been implanted in the proximal
part of left anterior descending artery at the site of angiographically and ergonovine-proven coronary spasm, with subsequent
in-stent restenosis.
Ein 55-jähriger Patient mit therapeutisch unkontrollierbaren koronaren Vasospasmen wurde 6 Monate nach Implantation der linken
A. mammaria interna zur Abklärung von Brustschmerzen vorstellig. We - gen der wiederholten vasospastischen Anfälle und Komplikationen
mit Kammerflimmern und Myokardinfarkt war zuvor ein Stent in die proximale LAD implantiert worden mit nachfolgender In-Stent-
Restenose, nachdem angiographisch und mittels Ergonovintest schwere Koronarspasmen festgestellt worden waren.
Herz 04/2012; 34(7):564-566. · 0.92 Impact Factor
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ABSTRACT: Almost all the studies of athlete's heart have been carried out on adult and older adolescent players; hence the limited data on the cardiac response to exercise in the beginning of the active sports career in the youngest athletes. The study was designed to examine the physiological limits of left ventricle (LV) cavity size and wall thickness in elite footballers at the preadolescent age, it the beginning of the active sports career. Ninety-four highly trained male footballers (mean aged 12.85±0.84) competing in the Serbian Football League and 47 age-matched healthy male controls, aged 12-14, were enrolled in the study. All the echocardiographic findings were adjusted to BSA(-0.5), while left ventricle mass (LVM) was additionally adjusted to BSA(-1.5). Reference ranges were defined as values of 5-95th centile according to the mean values in both groups. The proportions of the footballers with LV dimensions outside expected ranges were additionally noted. The data indicate significant increases in absolute values of LV dimensions, aortic root size and left atrium (p<0.001) in preadolescent professional footballers compared with the values expected for age-matched controls, whereas there are no differences in absolute values of ventricular septal and posterior wall thickness, LV wall thickness and LVM (p>0.05). Upon body-size adjustments, significant increases were observed in all echocardiographic parameters (p<0.001). Our data indicate an early cardiac remodeling, already apparent in pre-adolescence, even after a short period of training.
Journal of science and medicine in sport / Sports Medicine Australia. 05/2010; 13(6):602-6.
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Milan A Nedeljkovic,
Miodrag Ostojic,
Nebojsa Lalic,
Branko Beleslin,
Ivana Nedeljkovic,
Katarina Lalic, Miljko Ristic,
Vojislav Giga,
Lazar Angelkov,
Miloje Tomasevic,
Vladimir Kanjuh
[show abstract]
[hide abstract]
ABSTRACT: A 55-year-old man, with a history of medically uncontrolled coronary vasospasm, presented for evaluation of chest pain 6 months after implantation of left internal mammary artery. Due to recurrent episodes of vasospastic angina and serious complications of coronary spasm (ventricular fibrillation, myocardial infarction), a stent had previously been implanted in the proximal part of left anterior descending artery at the site of angiographically and ergonovine-proven coronary spasm, with subsequent in-stent restenosis.
Herz 11/2009; 34(7):564-6. · 0.92 Impact Factor
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The Journal of thoracic and cardiovascular surgery 07/2009; 137(6):1568-70. · 3.41 Impact Factor
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[hide abstract]
ABSTRACT: Chronic infections, such as periodontitis, have been associated with an increased risk for atherosclerosis and coronary artery disease. The aim of this study was to investigate biopsy samples of coronary and internal mammary arteries for the presence of putative pathogenic bacteria (Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Prevotella intermedia, and Tannerella forsythensis), Chlamydia pneumoniae, and human cytomegalovirus (CMV).
Patients with a diagnosis of coronary artery disease were included in the study. Fifteen coronary arteries with atherosclerosis and 15 internal mammary arteries without clinically assessable atherosclerotic degeneration were investigated. Both groups of specimens were obtained during coronary artery bypass grafting surgery. In all cases, the coronary and mammary artery specimens were taken from the same patient. The detection of periodontal pathogens, C. pneumoniae, and CMV was done by polymerase chain reaction analysis.
Bacterial DNA was found in nine of 15 (60%) coronary artery biopsy samples: P. gingivalis in eight (53.33%), A. actinomycetemcomitans in four (26.67%), P. intermedia in five (33.33%), and T. forsythensis in two (13.33%) samples; CMV was detected in 10 (66.67%) samples, and C. pneumoniae was detected in five (33.33%) samples. Some of the samples contained more than one type of bacteria. Periodontal pathogens were not detected in internal mammary artery biopsies, whereas CMV was present in seven (46.67%) samples and C. pneumoniae was present in six (40%) samples.
The absence of putative pathogenic bacteria in internal mammary arteries, which are known to be affected rarely by atherosclerotic changes, and their presence in a high percentage of atherosclerotic coronary arteries support the concept that periodontal organisms are associated with the development and progression of atherosclerosis.
Journal of Periodontology 04/2007; 78(4):677-82. · 2.60 Impact Factor
