Ximena Rodriguez

Publications (1)9.68 Total impact

• Source

  Available from: Veronica Burzio

  Article: Expression of a family of noncoding mitochondrial RNAs distinguishes normal from cancer cells.

  Verónica A Burzio, Claudio Villota, Jaime Villegas, Eduardo Landerer, Enrique Boccardo, Luisa L Villa, Ronny Martínez, Constanza Lopez, Fancy Gaete, Viviana Toro, Ximena Rodriguez, Luis O Burzio
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  ABSTRACT: We reported the presence in human cells of a noncoding mitochondrial RNA that contains an inverted repeat (IR) of 815 nucleotides (nt) covalently linked to the 5' end of the mitochondrial 16S RNA (16S mtrRNA). The transcript contains a stem-loop structure and is expressed in human proliferating cells but not in resting cells. Here, we demonstrate that, in addition to this transcript, normal human proliferating cells in culture express 2 antisense mitochondrial transcripts. These transcripts also contain stem-loop structures but strikingly they are down-regulated in tumor cell lines and tumor cells present in 17 different tumor types. The differential expression of these transcripts distinguishes normal from tumor cells and might contribute a unique vision on cancer biology and diagnostics.
  Proceedings of the National Academy of Sciences 07/2009; 106(23):9430-4. · 9.68 Impact Factor