Publications (3)2.11 Total impact
Article: [New etiopathogenic findings in renal cell carcinoma: carcinogenesis and tumor development pathways].[show abstract] [hide abstract]
ABSTRACT: Renal cancer is the third leading urological tumor after prostate and bladder cancers. Annual incidence of renal cancer in all stages has markedly increased in recent years. This represents a true increase in the number of actual cases that is not fully accounted for by widespread use of diagnostic imaging tests. This article is intended to provide an update on the carcinogenesis and tumor development pathways involved in the genesis of this tumor. Renal cell carcinoma (RCC) arises in renal epithelium and accounts for more than 90% of all malignant kidney tumors. Approximately 2% of RCCs are associated to hereditary syndromes, specific oncogenes, or changes in tumor suppressor genes. Changes in the VHL gene exist in all hereditary cases. This gene (located in the short arm of chromosome 3:3p25-26) is also involved in more than 60% of sporadic cases. This paper systematically addresses the latest findings on implications of the VHL gene in angiogenesis and its potential relationship to new molecules involved in management of RCC.Actas urologicas españolas 06/2009; 33(5):468-73. · 0.46 Impact Factor
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ABSTRACT: An atypical case of infertility associated with severe sperm abnormalities is presented. A 29-year-old man with 4 years of primary infertility had no history of significant illness, and no hereditary pathology or male infertility existed in his family. Physical examination of the patient showed no pathological findings. The analyses of four semen samples showed: sperm count, 67-83 10(6)/ml; 0% motility. The morphological analysis showed absence of flagellum, 14-16%; short-tail spermatozoa, 45-64%; coiled tails, 12-17%; and an abnormal proportion of spermatids and spermatocytes. Normal spermatozoa were found in 11-16%. Endocrine profile was found within the normal range. Testicular biopsy revealed impaired spermatogenesis. Scanning electron microscopy revealed sperm heads with intact nuclei and acrosomal regions. To our surprise, some of the stunted tails were uniflagellate. To our knowledge, this is a very uncommon case of sperm tail defect.TheScientificWorldJOURNAL 02/2007; 7:818-21. · 1.66 Impact Factor
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ABSTRACT: To report a case of leiomyoma of the bladder in a patient with unspecific urinary symptoms and discuss the utility of the diagnostic imaging techniques. A 56-year-old woman who consulted for unspecific urinary symptoms is described. Patient evaluation with ultrasound, CT and MRI showed a mass in the posterior aspect of the urinary bladder. Leiomyoma of the bladder is an uncommon benign tumor that is asymptomatic in most of the cases and is frequently discovered incidentally during assessment for other conditions. The case described herein presented with unspecific urinary symptoms. Patient evaluation with different diagnostic imaging techniques was required for correct diagnosis and treatment.Archivos españoles de urología 55(1):79-81.