Z Lu

Publications (2)4.01 Total impact

• Article: Elevated expressions of MMP7, TROP2, and survivin are associated with survival, disease recurrence, and liver metastasis of colon cancer.

  Y J Fang, Z H Lu, G Q Wang, Z Z Pan, Z W Zhou, J P Yun, M F Zhang, D S Wan
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  ABSTRACT: Colorectal cancer is one of the most common cancers worldwide. We tested the hypothesis that differences in the expression of certain molecular markers of colon cancer may account for different clinical outcomes. Tissue microarray technology was used to assay the expression of 17 biological markers [beta-catenin, CD44v7, c-myc, cyclin D1, estrogen receptor beta, mitogen-activated protein kinase/extracellular signal-regulated kinase, maspin, matrix metalloproteinase-7 (MMP7), p53, Pin1, peroxisome proliferators-activated receptor-gamma, survivin, T cell transcription factor 4 (TCF4), transforming growth factor beta receptor II (TGFbetaR II), TGFbeta, TROP2, and Wnt] by immunohistochemistry in 620 colon cancer patients. The Cox proportional hazards regression model was applied to analyze the lifetime data, including time to death, time to recurrence, and time to liver metastasis. All the markers were present at significantly higher expression levels in tumor specimens than in normal colonic specimens. Kaplan-Meier analysis showed that high expression of TROP2, MMP7, and survivin were related to decreased survival; TCF4 and TROP2 were related to disease recurrence; and CD44v7, cyclin D1, MMP7, p53, survivin, and TCF4 were related to liver metastasis. However, the results of the multivariate analysis only showed that expression of MMP7, survivin, and TROP2 were significant predictors of lower patient survival, while TROP2 and MMP7 were significantly related to disease recurrence and liver metastasis, respectively. We conclude that elevated survivin, MMP7, and TROP2 expression levels are related to decreased survival. In addition, elevated MMP7 and TROP2 expression levels are predictors of disease recurrence and liver metastasis, respectively.
  International Journal of Colorectal Disease 06/2009; 24(8):875-84. · 2.38 Impact Factor
• Article: Investigation of structural transformations in nanophase titanium dioxide by Raman spectroscopy

  W. Ma, Z. Lu, M. Zhang
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  ABSTRACT: ) prepared by acolloidal chemistry method. The evolution of the anatase phase upon annealing was characterized by frequency downshift, intensity increase, and linewidth sharpening of the lowest-frequency Eg mode. The rutile phase was shown to be stabilized at temperatures below 350°C and was postulated to reside in the surface region of the nanophase. The beginning and ending temperatures for the anatase–rutile transformation in the nanophase were found to be lower than those in single crystals or polycrystalline powders. The microscopic mechanism of the phase transformation was analyzed and the surface effect was suggested. An anomalous phenomenon of amorphization was also detected at the end of the anatase–rutile transformation in the nanophase TiO2.
  Applied Physics A 05/1998; 66(6):621-627. · 1.63 Impact Factor