Pimporn Luckprom

Publications (2)1.99 Total impact

• Article: Expression of IFN-gamma before and after treatment of oral lichen planus with 0.1% fluocinolone acetonide in orabase.

  Pornpan Youngnak-Piboonratanakit, Kittipong Dhanuthai, Kobkan Thongprasom, Pimporn Luckprom, Wilairat Sarideechaigul, Lakana Luangjarmekorn, Miyuki Azuma
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  ABSTRACT: Oral lichen planus (OLP) is a common chronic inflammatory mucosal disease in which T-cell-mediated immune responses are implicated in the pathogenesis. The purpose of this study was to investigate the effect of 0.1% fluocinolone acetonide in orabase (FAO) on the in situ expression of IFN-gamma in patients with OLP. Twenty OLP patients were enrolled in this study. Biopsy specimens and serum samples were obtained before and 1-month after the treatment with 0.1% FAO. In situ expression and serum levels of IFN-gamma were determined using immunohistochemistry and ELISA, respectively. The number of IFN-gamma-positive mononuclear cells in OLP lesions before the treatment was significantly higher as compared with that after the treatment. Similarly, the mean number of total mononuclear cells was clearly decreased after the treatment. However, the serum levels of IFN-gamma were not detectable. Our results suggest that IFN-gamma expression in OLP tissue may involve in the immunopathogenesis and the treatment with 0.1% FAO had an immunomodulating effect on the decrease of IFN-gamma.
  Journal of Oral Pathology and Medicine 08/2009; 38(9):689-94. · 1.63 Impact Factor
• Source

  Available from: Kobkan Thongprasom

  Article: Oral lichen planus: a retrospective comparative study between Thai and Croatian patients.

  Kobkan Thongprasom, Marinka Mravak-Stipetić, Pimporn Luckprom, Ivana Canjuga, Dolores Biocina-Lukenda, Danica Vidović-Juras, Miroslav Sikora, Vlaho Brailo, Supachote Jirawechwongsakul
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  ABSTRACT: Oral lichen planus (OLP) is a common oral mucosal disease that affects middle age patients. However, there are few reports about the incidence of OLP in different ethnic groups. The purpose of this study was to compare the characteristics of OLP in Thai and Croatian patients. Retrospective data were taken from medical records of 175 patients referred to the Oral Medicine Department of Chulalongkorn University and 175 patients referred to the School of Dental Medicine, University of Zagreb during the 1997-2007 period. In all patients the diagnosis of OLP was clinically and histopathologically confirmed. In Thai and Croatian OLP patients, females were predominant (the female to male ratio was 3.5:1). Croatian OLP patients were older with a significant age difference between female Thai and Croatian OLP patients (p<0.05). Atrophic-erosive type of OLP was common in Thai patients, whereas reticular OLP was predominant in Croatians (p<0.001). Burning sensation was the most common chief complaint in both ethnic groups. Significant differences between the two ethnic groups were found in the sites of OLP lesions as well as in the occurrence of pain, roughness and white patches, systemic diseases and use of medication (p<0.05). Croatian patients had more systemic diseases and took more medications than Thai. Three cases showed dysplasia in either group, whereas only one Thai patient developed squamous cell carcinoma. Although Thai and Croatian patients differed significantly according to the clinical type of OLP, the rate of malignant transformation was very low.
  Acta dermatovenerologica Croatica: ADC / Hrvatsko dermatolosko drustvo 05/2009; 17(1):2-8. · 0.36 Impact Factor