C Mummery

Publications (2)7.16 Total impact

• Source

  Available from: PubMed Central

  Article: Delusions in frontotemporal lobar degeneration.

  Rohani Omar, Elizabeth L Sampson, Clement T Loy, Catherine J Mummery, Nick C Fox, Martin N Rossor, Jason D Warren
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  ABSTRACT: We assessed the significance and nature of delusions in frontotemporal lobar degeneration (FTLD), an important cause of young-onset dementia with prominent neuropsychiatric features that remain incompletely characterised. The case notes of all patients meeting diagnostic criteria for FTLD attending a tertiary level cognitive disorders clinic over a three year period were retrospectively reviewed and eight patients with a history of delusions were identified. All patients underwent detailed clinical and neuropsychological evaluation and brain MRI. The diagnosis was confirmed pathologically in two cases. The estimated prevalence of delusions was 14%. Delusions were an early, prominent and persistent feature. They were phenomenologically diverse; however paranoid and somatic delusions were prominent. Behavioural variant FTLD was the most frequently associated clinical subtype and cerebral atrophy was bilateral or predominantly right-sided in most cases. We conclude that delusions may be a clinical issue in FTLD, and this should be explored further in future work.
  Journal of Neurology 05/2009; 256(4):600-7. · 3.47 Impact Factor
• Article: A novel presenilin 1 deletion (p.L166del) associated with early onset familial Alzheimer's disease.

  W D Knight, J Kennedy, S Mead, M N Rossor, J Beck, J Collinge, C Mummery
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  ABSTRACT: We report the case of a 40 year-old woman who, at 38 years of age, developed insidious memory loss and, subsequently, progressive dementia satisfying criteria for probable Alzheimer's disease (AD) (NINCDS-ADRDA) [Neurology 1984; 34: 939]. Analysis of the presenilin 1 gene (PSEN1) revealed a 496_498delCTT mutation at codon 166. The amnestic presentation and absence of other features contrasts with the majority of other documented deletions which have been associated with spastic paraparesis. They are, however, consistent with the reported clinical phenotype in the majority of PSEN1 exon 6 mutations so far reported.
  European Journal of Neurology 08/2007; 14(7):829-31. · 3.69 Impact Factor