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ABSTRACT: Merkel cell carcinoma (MCC) is a rare cutaneous tumor and cases located in the eyelid have been described, but still its rarity may lead to difficulty in diagnosis and delay in treatment. A 51-year-old female patient that presented with large lesions in the eyelid underwent surgery after the diagnosis of acute chalazion. Following respiratory distress secondary to pulmonary metastasis, the patient's condition deteriorated and was not fit for complete excision treatment. Histopathological investigation of the biopsies, taken from the tumor, revealed that it was undifferentiated small cell carcinoma. Our aim with this paper is to point out that more cases should be reported for more effective diagnosis, histopathological study, clinical investigation, treatment and prognosis of this specific neoplasm.
World Journal of Surgical Oncology 01/2011; 9:58. · 1.12 Impact Factor
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ABSTRACT: This study aimed to investigate the influence of different microenvironments on melanoma microcirculation patterns, invasiveness and metastatic behavior. Sixty C57BL/6J mice were randomly divided into two groups with 30 mice per group. Melanoma B16 cells were injected into the subretinal space and groin area of mice synchronously. The number of each type of microcirculation pattern was counted. Invasion and metastasis were observed. Epithelial cell kinase (EphA2), matrix metalloproteinase (MMP)-2 and -9 expression and their mRNA levels were detected by immunohistochemical staining and real-time PCR and compared between the two groups. Five invasions and six lung metastases were found in the subretinal group while no invasion and metastasis were found in the groin group. The number of vasculogenic mimicry (VM) was significantly higher in the subretinal group (P=0.000). However, no significant difference in the numbers of mosaic and endothelium-dependent vessels was observed between the two groups (P=0.076 and 0.146, respectively). EphA2, MMP-2 and MMP-9 expression was significantly higher in the subretinal group. The mRNA levels of EphA2, MMP-2 and MMP-9 were slightly higher in the subretinal tumors (P=0.002, 0.001 and 0.001, respectively). In conclusion, this experimental paradigm can be a powerful one in which to investigate tumor-microenvironment interactions in melanoma. Tumor cells in the intraocular microenvironment had increased EphA2 expression which induced the formation of VM channels. Moreover, expression of MMP-2 and -9 in tumor tissue was increased to enhance the invasiveness and metastatic behavior.
Oncology Reports 05/2009; 21(4):917-23. · 1.84 Impact Factor
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ABSTRACT: To analyze and summarize the clinical signs, the diagnostic and differential diagnostic value of imaging examination in orbital inflammatory pseudo-tumors and the comparison of the therapeutic effect of various treatments.
Retrospectively, 271 cases (303 eyes) of orbital inflammatory pseudotumors were analyzed.
Ultrasonography and CT had their diverse manifestations according to the different characterizations of the histopathology of tumors. B-ultrasonography showed a tumor with low reflection and strong sound transmission in diffuse lymphocytic infiltrative pseudotumor. A tumor with fibro-proliferative lesion had low reflection, weak sound transmission and irregular border. CT showed lesions touching closely with the globe. Steroid and radiotherapy were effective for diffuse lymphocytic infiltrative pseudotumors. The various therapies were not effective for fibro-proliferative lesions.
Imaging examinations are valuable for the diagnosis, differential diagnosis, the evaluation of histopathology types and the choice of treatment for orbital inflammatory pseudotumors.
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology 09/2002; 38(8):484-7.
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ABSTRACT: To investigate the histopathologic classification and distribution of orbital diseases.
The authors analyzed 3 476 orbital diseases examined in 1976 - 2000 in the pathology laboratory.
Benign orbital diseases were 81.90%. The 10 leading benign orbital diseases were cavernous hemangioma (515), vascular leiomyoma (364), inflammatory pseudotumor (347), dermoid (230), schwannoma (183), meningioma (150), benign mixed tumor of the lacrimal gland (147), mucocele (141), varix (132) and neurofibroma (76). Malignant orbital tumors were 18.10%. The numbers of malignant tnmors were malignant lacrimal gland epithelial tumors (129, 20.51%), rhabdomyosarcoma (75), non-Hodgkin's disease (65), secondary to nasosinus carcinoma (51), metastatic tumor (50), chloroma (32), extraocular extension of retinoblastoma (26) and extraocular extension of choroid malanoma (23).
The vascular tumors and malformations are commonly seen in orbital diseases. The primary malignant tumor in the orbit is the malignant lacrimal gland epithelial tumors.
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology 08/2002; 38(7):396-8.
