Sang Min Kim

Sungkyunkwan University, Sŏul, Seoul, South Korea

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Publications (70)128.17 Total impact

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    ABSTRACT: The purpose of this study was to investigate the correlation between rotational axes of femur and tibia with the use of Linker. This study was carried out from August 2009 to February 2010 on 54 patients (106 knees), who were diagnosed with simultaneous bilateral total knee arthroplasty. With the use of postoperative computed tomography scans, it was investigated how much the rotational angle of femoral and tibial components matched. The tibial component was internally rotated for the femoral component at an angle of 0.8°. The femoral component was externally rotated for the surgical transepicondylar axis (TEA) at an angle of 1.6 (range: from 4.8° of internal rotation to 7.9° of external rotation, SD=2.2°), and the tibial component was externally rotated for the surgical TEA at an average angle of 0.9 (range: from 5.1° of internal rotation to 8.3° of external rotation, SD=3.1°). The femoro-tibial synchronizer helped to improve the orientation and positioning of both femoral component and tibial component, and also increase the correlation of the rotational axes of the two components.
    Yonsei medical journal. 03/2015; 56(2):454-9.
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    ABSTRACT: Chloroacetamide (CAA) is a preservative used in various cosmetic, personal care and household products. Due to the hazard potential for allergic reaction and reproductive toxicity, CAA is being considered a high priority for screening assessment and toxicological re-evaluation. This study describes the development of a highly specific and sensitive atmospheric pressure chemical ionization tandem mass spectrometry method for the determination of CAA in rat plasma and its application to a topical bioavailability study. Chromatographic separations were achieved on a C8 column using a highly aqueous mobile phase with a binary gradient elution. The assay was linear in the concentration range of 5-2,500 ng/mL (r ≥ 0.995) using a small sample volume (100 µL). Applicability of the assay was demonstrated in a bioavailability study in rats after i.v. injection (0.5 or 2 mg/kg) and topical application (7.02 mg/kg). Average elimination half-life and clearance ranged from 26.6 to 30.5 min and 53.9 to 57.3 mL/min/kg, respectively. Upon topical application, CAA was slowly but steadily absorbed for a prolonged time period (12 h). The topical bioavailability was 53.5 and 48.3% for emulsion and lotion, respectively. The developed assay may be useful to examine the relationship between exposure and toxic potential of CAA in risk assessment. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
    Journal of chromatographic science 12/2014; · 1.03 Impact Factor
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    ABSTRACT: The aim of this study is to know whether silibinin has an anticancer effect on triple negative breast cancer xenograft model using MDA-MB-468 cells.
    Annals of surgical treatment and research. 10/2014; 87(4):167-73.
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    ABSTRACT: This study aims to investigate the bioavailability of ginsenosides during simulated digestion of white (WG) and red (RG) ginseng powder. Stability, bioaccessibility and permeability of ginsenosides present in WG and RG were studied in a Caco-2 cell culture model coupled with an oral, gastric, and small intestinal simulated digestion. Most ginsenosides in WG and RG were stable (> 90%) during the simulated digestion. Bioaccessibility of total ginsenosides during in vitro digestion of WG and RG was similar at approximately 85%. However, the bioaccessibility of protopanaxatriol type ginsenosides in the early food phase was greater than that of the protopanaxadiol type. The less polar RG ginsenosides were released later following the jejunum phase. Ginsenosides had low permeability (< 1 × 10-6 cm/s) through Caco-2 cell monolayers. These findings suggest that the WG and RG ginsenoside compositions affect bioaccessibility during digestion and that ginsenosides are poorly absorbed in humans.
    Journal of Agricultural and Food Chemistry 08/2014; · 3.11 Impact Factor
  • European Food Research and Technology 08/2014; · 1.39 Impact Factor
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    Ya Fang Shang, Sang Min Kim, Byung-Hun Um
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    ABSTRACT: To develop an efficient green extraction approach for recovering bioactive compounds from natural plants, the potential of using pressurised liquid extraction (PLE) was examined on black bamboo (Phyllostachys nigra) leaves, with ethanol/water as solvents. The superheated PLE process showed a higher recovery of most constituents and antioxidative activity, compared to reflux extraction, with a significantly improved recovery of the total phenolic (TP) and flavonoid (TF) content and DPPH radical scavenging ability. For a broad range of ethanol aqueous solutions and temperatures, 50% EtOH and 200 °C (static time: 25 min) gave the best performance, in terms of the TP and TF (75% EtOH) content yield and DPPH scavenging ability (25% EtOH). Under the optimised extraction conditions, eight main antioxidative compounds were isolated and identified with HPLC-ABTS+ assay guidance and assessed for radical scavenging activity. The superheated extraction process for black bamboo leaves enhanced the antioxidant properties by increasing the extraction of the phenolic components.
    Food Chemistry 07/2014; 154:164–170. · 3.26 Impact Factor
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    ABSTRACT: We report a 53-year-old woman who suffered acute visual loss 10 days after cardiopulmonary cerebral resuscitation (CPCR) performance. Immediately after she had performed CPCR she developed floater symptoms in her left eye, which persisted for 2 hours, and she was diagnosed with Valsalva retinopathy. Ten days later, she had an acute painless visual loss in the same eye (visual acuity 20/1000). On fundus examination optic disc edema, peripapillary hemorrhage, and retinal artery occlusion were detected in the superior half of her left retina and she was diagnosed with branch retinal artery occlusion (BRAO). Four months later, her visual acuity had increased to 20/40; however, the inferior altitudinal visual field defect remained. To rule out cardiac associations of BRAO, transesophageal echocardiography was performed and a patent foramen ovale on her atrial septum was detected. This case indicates a possible risk that emergency medical personnel could have medical problems while performing strenuous tasks to help other people.
    American Journal of Emergency Medicine 05/2014; · 1.15 Impact Factor
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    ABSTRACT: Metal elements occupy more than 70% of the positions in the periodic table, and their use has accelerated human civilization due to their invaluable chemical and physical characteristics. With the rapid development of metals, various structures of microscopic metal particles have been fabricated and investigated as functional materials in scientific research and practical applications. The phrase 'structure determines properties' has been widely acknowledged as a golden rule in chemistry and materials science, especially when the size of small particles is in the micro- or nanoscale dimension. Helical metallic micro- and nanostructures with complex shapes have recently emerged and may be used for various useful applications such as photonics, sensors, actuators, micro-/nanorobotics, and micro-/nanoelectronics, based on their unique mechanical, electrical, and electromagnetic properties. This review paper specifically focuses on the fabrication and application of helical metallic structures with a size ranging from the micro- to nanoscale. The unusual spatial distribution of active atoms in helical metallic micro- and nanostructures and their helical morphology could offer new opportunities for applications beyond those of other conventional metallic and nonmetallic micro- and nanostructures.
    Nanoscale 04/2014; · 6.74 Impact Factor
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    ABSTRACT: In this work, we successfully synthesized a vertically-aligned bimetallic Pt/Pd nanotube array by using anodic aluminum oxide (AAO) template-assisted electro-deposition. The resulting nanostructures exhibited higher catalytic activity in methanol oxidation than either individual constituent (Pt or Pd). The facile synthesis of the Pt/Pd tubular nanostructure was inspired by the previously developed thin-walled Pd nanotube formation mechanism, which takes advantage of the surface hydroxyl chemistry of the AAO template. The content of Pt in the bimetallic Pt/Pd nanotubes could reach up to 50%. The inner and outer walls of the perpendicular open Pt/Pd nanotubes increased the ratio of the surface area to the mass relative to the solid nanorod structure, resulting in a higher current density in methanol oxidation. More importantly, the synergistic electronic effect between Pt and Pd gave rise to the enhanced catalytic activity in methanol oxidation, as evidenced from comparisons of the onset potentials and CO oxidation behaviors. Thus, vertically-aligned bimetallic Pt/Pd nanotubes may act as a better catalyst in methanol oxidation than the single-component Pt counterpart.
    Journal of Materials Chemistry 10/2013; 1(48):15252-15257. · 6.63 Impact Factor
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    ABSTRACT: Glycoprotein IIb/IIIa antagonists are well established for their effectiveness in improving clinical outcomes in acute coronary syndrome patients undergoing percutaneous coronary intervention. Acute profound thrombocytopenia is a rare complication of abciximab. We present a case which was managed successfully for the rare complication of acute profound thrombocytopenia after using abciximab and an intra-aortic balloon pump for the treatment of a no-reflow phenomenon and consecutive cardiogenic shock during primary percutaneous coronary intervention.
    Korean Circulation Journal 08/2013; 43(8):557-60.
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    ABSTRACT: Due to their diversity and abundancy, marine resources have emerged as important biological resources to compensate the limited sources of terrestrial biological materials. Phaeodactylum tricornutum (PT) is one of classical model diatoms most widely studied for its ecology, physiology, biochemistry and molecular biology. In this study, four different PT extracts on lipopolysaccharide (LPS)-stimulated macrophages were compared for anti-inflammatory effect and investigated for the underlying mechanisms. The extracts of PT inhibited nitric oxide production from LPS stimulated RAW 264.7 cells in a dose dependent manner. These extracts also inhibited the expression of mRNA and production of proteins of pro-inflammatory cytokines such as interleukin (IL)-, IL-6 and tumor necrosis factor-. These inhibitory effects were found to be caused by blockage of nuclear factor- activation and phosphorylation of p38 mitogen-activated protein kinases, extracellular signal-regulated kinases 1 and 2 and c-Jun N-terminal kinase.
    Journal of Applied Biological Chemistry 06/2013; 56(2).
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    ABSTRACT: In this study, a hydrophilic interaction chromatography (HILIC) condition was developed for the simultaneous determination of five major phlorotannins from an extract of Eisenia bicyclis (Kjellman) Setchell with good linearity (r(2)>0.999). Based on this method, the seasonal variations and extraction characteristics, in terms of total extraction yield and the content of the phlorotannins, were investigated under various extraction conditions. In results, the yields and phlorotannins were increased two-to-four times in summer (June-October) and then, were decreased to normal levels in winter (November-March). In the extraction of E. bicyclis, ethanol percentage in water, extraction time and washing time significantly affected the yield of the extract and the phlorotannins, whereas the temperature and the sample/solvent ratio impacted the extraction to a lesser degree. These results will be useful information in the application of this macroalga in the commercial areas related to nutraceuticals, pharmaceuticals, and cosmeceuticals.
    Food Chemistry 06/2013; 138(4):2399-406. · 3.26 Impact Factor
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    ABSTRACT: BACKGROUND: Chrysanthemum indicum L. flower (CIF) has been widely used as tea in Korea. This study aims to investigate the hepatoprotective effect of the hot water extract of CIF (HCIF) in in vitro and in vivo systems. METHODS: Hepatoprotective activities were evaluated at 250 to 1000 mug/ml concentrations by an in vitro assay using normal human hepatocytes (Chang cell) and hepatocellular carcinoma cells (HepG2) against CCl4-induced cytotoxicity. Cytochrome P450 2E1, which is a key indicator of hepatic injury, was detected by western blot analysis using rabbit polyclonal anti-human CYP2E1 antibody. An in vivo hepatoprotective activity assay was performed at 1000 to 4000 mug/ml concentrations on CCl4-induced acute toxicity in rats, and the serum levels of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) were determined by standard enzyme assays. RESULTS: The hepatoprotective effects of HCIF significantly reduced the levels of GOT (60.1%, P = 0.000) and GPT (64.5%, P = 0.000) compared with the vehicle control group (CCl4 alone). The survival rates of HepG2 and Chang cells were significantly improved compared with the control group [82.1% (P = 0.034) and 62.3% (P = 0.002), respectively]. HCIF [50 mg/kg body weight (BW)] treatment significantly reduced the serum levels of GOT (49.5%, P = 0.00), GPT (55.5%, P = 0.00), ALP (30.8%, P = 0.000) and LDH (45.6%, P = 0.000) compared with the control group in this in vivo study. The expression level of cytochrome P450 2E1 (CYP2E1) protein was also significantly decreased at the same concentration (50 mg/kg BW; P = 0.018). CONCLUSION: HCIF inhibited bioactivation of CCl4-induced hepatotoxicity and downregulates CYP2E1 expression in vitro and in vivo.
    Chinese Medicine 04/2013; 8(1):7. · 2.34 Impact Factor
    This article is viewable in ResearchGate's enriched format
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    ABSTRACT: In this study, methanol extracts from 25 indigenous Korean corals were prepared and their carotenoid constituents were analyzed by high-performance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry (HPLC-APCI-MS). Among them, extracts from nine species showed detectable peaks in the HPLC chromatogram at 450 nm and the ultraviolet/visible spectra exhibiting carotenoid-specific characteristics were chosen. The mass data of carotenoid peaks revealed that only peridinin could be identified based on literature comparison and suggested the potential presence of novel carotenoid structures. This is the first reported investigation of indigenous Korean coral carotenoids and further work is needed to explore the carotenoids and their potential roles in the ecosystem of indigenous Korean corals.
    Journal of Applied Biological Chemistry 03/2013; 56(1).
  • Kwang Ho Lee, Sang Min Kim, Jong Ho Yoon
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    ABSTRACT: Underfloor air distribution (UFAD) systems have received increasing attention during the past decades due to potential advantages over conventional overhead (OH) forced air systems. Among design and operating parameters, air handling unit (AHU) supply air temperature (SAT) has significant impacts on the overall UFAD performance. In this study, the detailed whole-building energy simulation program, EnergyPlus version 6.0, was used to perform the analysis on the impact of SAT on the UFAD system performance such as energy, humidity and comfort under Korean climatic condition. It turns out that raising AHU SAT causes increased HVAC energy consumption due to heating and fan energy increase despite the cooling energy reduction. The increase in the heating energy was mainly due to the increased central AHU heating coil demand increase with the higher SAT. In addition, raised SAT elevated relative humidity in the room space during the summer season due to the fact that higher SAT set-point in the central AHU was not able to sufficiently dehumidify conditioned air compared to the lower SAT. However, the increased SAT reduced the number of hours when the occupants might feel cold during the heating season in the interior zone where the heating is not provided.
    Energy and Buildings 03/2013; 58:363–371. · 2.47 Impact Factor
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    ABSTRACT: Hexane extracts of needles and defoliated twigs of Pinus pumila (Pall.) Regel from two distant populations, located in the southwest and the east (i.e., Lake Baikal region and Sakhalin Island) of the species distribution range were studied by GC/MS analysis. Composition and retention indices of major components were determined. A drastic composition divergence for the extracts of P. pumila needles and defoliated twigs, depending on growth location, was established. Needle extracts from the eastern population sample contained mainly labdane-type acids (anticopalic acid derivatives), whereas the predominant components of needle extracts from the other population sample were abietane-type acids (abietic, neoabietic acids) and isopimarane-type diterpenoids (sandaracopimaric acid, sandaracopimaradien-3β-ol). The main components of defoliated twig extracts from Sakhalin Island population sample were abietane-type acids and cembrane-type diterpenoids, while content of these compounds in the extracts of the southwestern marginal population sample was remarkably lower.
    Chemistry & Biodiversity 02/2013; 10(2):198-208. · 1.81 Impact Factor
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    ABSTRACT: Hypothesis Needle lavage is frequently performed before consideration of surgical removal in shoulders with calcific tendinitis because this may avoid surgery. However, its role in nonoperative treatment has not been fully investigated in terms of clinical and radiographic response. We hypothesized that needle decompression and subacromial steroid injection would show good clinical results in chronic calcific tendinitis patients. Materials and methods Thirty-five shoulders in 30 consecutive patients with painful calcific tendinitis were treated by ultrasound-guided needle decompression and subacromial corticosteroid injection. Patients were prospectively evaluated using American Shoulder and Elbow Surgeons (ASES) and Constant scores at 1, 3, and 6 months after the intervention. Size and morphology of the calcific deposits were compared with those in baseline radiographs at each visit. Results At 6 months after the index procedure, 25 shoulders (71.4%) showed ASES and Constant score improvements from 48.0 and 53.7 to 84.6 and 87.9, respectively (P < .01). Ten shoulders (28.6%) showed no symptom relief at the last follow-up. In shoulders with pain improvement, the mean size of calcific deposits reduced from 13.6 to 5.6 mm (P < .01), and in shoulders with no pain improvement or that underwent operation, mean size was 13.1 mm at initial visits and 12.7 mm at final visits (P = .75). Discussion Shoulders showing little evidence of deposit size reduction at 6 months after needle decompression are less likely to achieve symptomatic improvement and may be considered as candidates for surgical removal. Conclusion Needle decompression with subacromial steroid injection is effective in 71.4% of calcific tendinitis within 6 months. The size of calcific deposits in patients that achieved symptom relief was reduced.
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    ABSTRACT: Aldo-keto reductase family 1 member B10 (AKR1B10) belongs to a superfamily of NADPH-dependent aldo-keto reductases and is considered a biomarker of several cancers. Inhibition of recombinant human AKR1B10 (rhAKR1B10) was assayed using 31 seaweed extracts, among which, an Eisenia bicyclis extract was selected for further study. To identify the compounds in E. bicyclis responsible for inhibitory effects on rhAKR1B10, five compounds were isolated by bioactivity-guided fractionation and isolation. Among them, phlorofucofuroeckol-A (PFF-A), isolated from an ethyl acetate fraction, exhibited the greatest inhibition of rhAKR1B10. The inhibitory rate of PFF-A against rhAKR1B10 was 61.41% at 10 mu M, with an IC50 of 6.22 mu M. Enzyme kinetic analyses revealed non-competitive inhibition with a K-D of 2.76 mu M. These results indicate that PFF-A from E. bicyclis may be a promising anticancer agent.
    Journal of the Korean Society for Applied Biological Chemistry 12/2012; 55(6-6):721-727. · 0.54 Impact Factor
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    ABSTRACT: Since microbial gene sequencing was utilized for etiologic diagnosis of culture-negative endocarditis, cases of Bartonella endocarditis have been reported in various countries. Herein we report the first case of Bartonella quintana endocarditis, which was confirmed for the first time in Korea by 16S rRNA gene sequencing from the excised valve. A 75-yr-old woman was hospitalized due to dyspnea. Echocardiography demonstrated large oscillating vegetation at the aortic valve. Blood culture was negative. She underwent valve replacement and sequencing of the 16S rRNA gene from excised valve identified Bartonella quintana. She was successfully treated with combined use of ceftriaxone and gentamicin.
    Journal of Korean medical science 11/2012; 27(11):1433-5. · 0.84 Impact Factor
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    ABSTRACT: Thioredoxin-1 (Trx-1) is one of important anti-oxidative molecules to overcome the oxidative stress. The aim of the present study is to investigate the clinical relationship between serum concentration of Trx-1 on the pre-percutaneous coronary intervention (prePCI) and myocardial damage amount in the patients with acute myocardial infarction with the culprit lesion in only the left anterior descending artery on coronary angiography (n = 100). Initial value of creatine kinase (CK) was 368.3 ± 531.4 U/L, and MB isoenzyme of CK (CK-MB) level was 22.92 ± 33.8 ng/mL, and cardiac specific troponin T (cTnT) level was 0.61 ± 1.6 ng/mL. Positive correlations were observed between prePCI Trx-1 level and initial CK (P = 0.005, r = 0.281), and cTnT (P < 0.001, r = 0.453), peak CK (P = 0.001, r = 0.316) in all patients, but the statistical relation was observed only in ST segment elevation myocardial infarction (STEMI) patients (P = 0.008, r = 0.329 for initial CK, P = 0.001, r = 0.498 for initial cTnT, P = 0.005, r = 0.349 for peak CK), not in Non-STEMI patients. Conclusively, we consider prePCI serum Trx-1 as a predictor for myocardial damage amount in patients with STEMI.
    Journal of Korean medical science 10/2012; 27(10):1162-9. · 0.84 Impact Factor
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Publication Stats

387 Citations
128.17 Total Impact Points

Institutions

  • 2008–2015
    • Sungkyunkwan University
      • • Department of Orthopedic Surgery
      • • Department of Chemistry
      • • Department of Energy Science
      • • Department of Internal Medicine
      • • Department of Surgery
      Sŏul, Seoul, South Korea
  • 2010–2014
    • Chungbuk National University
      • Department of Internal Medicine
      Chinsen, North Chungcheong, South Korea
  • 2013
    • Hyundai Engineering Co., Ltd.
      Sŏul, Seoul, South Korea
    • Daegu University
      • Department of Biotechnology
      Daikyū, Daegu, South Korea
  • 2012
    • Kyungpook National University
      • Department of Energy Chemical Engineering
      Daikyū, Daegu, South Korea
  • 2011–2012
    • Korea Institute of Science and Technology
      Sŏul, Seoul, South Korea
    • Pusan National University
      • Department of Physics
      Tsau-liang-hai, Busan, South Korea
  • 2009
    • Hanyang University
      • Department of Bio-Nano Technology
      Sŏul, Seoul, South Korea
    • Konkuk University
      • Department of Dermatology
      Sŏul, Seoul, South Korea
  • 2007–2008
    • Kyung Hee University
      • College of Electronics and Information
      Sŏul, Seoul, South Korea
    • Virginia Polytechnic Institute and State University
      • Department of Biological Systems Engineering
      Blacksburg, VA, United States
    • Gyeongsang National University
      Shinshū, South Gyeongsang, South Korea