Julia Langer

Publications (3)5.46 Total impact

• Article: Far field potentials from brain stem after transcutaneous vagus nerve stimulation: optimization of stimulation and recording parameters.

  Thomas Polak, Falko Markulin, Ann-Christine Ehlis, Julia B M Langer, Thomas M Ringel, Andreas J Fallgatter
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  ABSTRACT: The method of vagus somatosensory evoked potentials (VSEP) was introduced to easily measure the activity of vagus brain stem nuclei. In Alzheimer's disease, this measure was characterized by longer latencies as compared to controls while amplitudes did not show statistical significant differences at frontal and central recording sites. Therefore, the influence of stimulation and recording parameters on amplitudes of VSEP were systematically examined. In 20 healthy participants, VSEP measurement was done by electrical stimulation of the cutaneous representation of the vagus nerve in the external auditory channel and recording of VSEP over the scalp. The optimum stimulation intensity is 8 mA without perception of pain. There is no effect of stimulation side or gender. Maximum VSEP amplitudes are detected at bipolar recordings comprising the electrode T4 without statistically significant differences of latencies, wave shape and polarity. Thus, recordings of future examinations should be performed at 8 mA including this temporal electrode position. The reason for focussing on brain stem evoked potentials is that recent work has accumulated evidence for this area being involved in early phases of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Improved methodological knowledge may facilitate the assessment of this non-invasive and cost-effective method in the early diagnosis of neurodegenerative disorders.
  Acta Neurovegetativa 10/2009; 116(10):1237-42. · 2.73 Impact Factor
• Article: Auricular vagus somatosensory evoked potentials in vascular dementia.

  Thomas Polak, Falko Markulin, Ann-Christine Ehlis, Florian Metzger, Julia B Langer, Thomas M Ringel, Andreas J Fallgatter
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  ABSTRACT: A new method for the assessment of vagus nerve function has recently been introduced into clinical practice. In the present study we could show that, contrary to our results in Alzheimer's disease (AD), in patients with vascular dementia (VaD) vagus sensory evoked potentials (VSEP) did not show statistically significant differences as compared to healthy controls. Thus, we hypothesize that the new method of VSEP could possibly contribute to a differential diagnosis between early cases of AD and VaD.
  Acta Neurovegetativa 04/2009; 116(4):473-7. · 2.73 Impact Factor
• Chapter: Wahrnehmung — Psychologie

  Andreas Fallgatter, Julia Langer, Tilo Kircher, Siegfried Gauggel
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  ABSTRACT: Kognitive Dysfunktionen und Defizite in der Aufmerksamkeit sind im Rahmen der Krankheitsbilder aus dem schizophrenen Formenkreis gut bekannt und erforscht. Es stellt sich jedoch die Frage, ob Störungen in der Informationsverarbeitung zeitlich nicht schon wesentlich früher auftreten, also noch bevor die Aufmerksamkeit auf einen Reiz gerichtet und er kognitiv verarbeitet wird: in der Wahrnehmung.
  12/2007: pages 145-154;