[show abstract] [hide abstract]
ABSTRACT: ObjectiveIt is an open question whether multifunctional galectin-3 can be a serum marker in inflammatory bowel disease.
MethodsWestern blots and commercial ELISA detected and quantitated the lectin immunocytochemistry using double labeling localized
it in tissue sections.
ResultsSerum concentrations were significantly increased in specimen of patients with active and remission-stage ulcerative colitis
and Crohn’s disease, associated with emerging positivity of CD14+ cells.
ConclusionEnhanced concentration of galectin-3 in serum reflects presence of disease and points to its involvement in the pathogenesis.
Inflammation Research 04/2012; 58(8):503-512. · 1.96 Impact Factor