Anne-Marie Brouwer

Publications (3)14.24 Total impact

• Article: No changes in efavirenz plasma concentrations in HIV-infected patients who switch from Stocrin to Atripla.

  David Burger, Matthijs van Luin, Marjolein Bosch, Andre van der Ven, Anne-Marie Brouwer, Monique Keuter, Ton Dofferhoff, Peter P Koopmans
  JAIDS Journal of Acquired Immune Deficiency Syndromes 08/2010; 54(5):e12-3. · 4.43 Impact Factor
• Source

  Available from: Ahmad Rizal Ganiem

  Article: The effect of HIV infection on adult meningitis in Indonesia: a prospective cohort study.

  A Rizal Ganiem, Ida Parwati, Rudi Wisaksana, Adri van der Zanden, Diederik van de Beek, Patrick Sturm, Andre van der Ven, Bachti Alisjahbana, Anne-Marie Brouwer, Nani Kurniani, Jan de Gans, Reinout van Crevel
  [show abstract] [hide abstract]
  ABSTRACT: Indonesia has a concentrated but rapidly growing HIV epidemic. We examined the effect of HIV on causative organisms, clinical features and prognosis of adult meningitis. A prospective cohort study. All adult patients at a referral hospital who underwent cerebrospinal fluid examination for suspected meningitis were examined for HIV and included in a prospective cohort study. Microbiological testing was done for common bacterial pathogens, mycobacteria and fungi. Patients were followed for at least 6 months, and logistic regression models were used to identify risk factors for mortality. Among 185 patients who mostly presented with subacute meningitis, 60% were male and the median age was 30 years. HIV infection was present in 25% of the patients; almost two-thirds were newly confirmed, and all presented with severe immunosuppression (median CD4 cell count 13/microl, range 2-98). One-third of HIV-infected patients had cryptococcal meningitis whereas two-thirds suffered from tuberculosis. After 1 month, 41% of patients had died. HIV infection was strongly associated with 1-month mortality (adjusted odds ratio 12.15; 95% confidence interval 3.04-15.72) and death during extended follow-up (hazard ratio 2.48; 95% confidence interval 1.97-5.74). Although HIV is still uncommon in the general population in Indonesia, its prevalence among adult meningitis cases already seems high. Mycobacterium tuberculosis and Cryptococcus neoformans are the main causes of meningitis in this setting, and mortality is very high, especially in HIV-infected patients. Our data suggest that adult meningitis cases in Indonesia should be screened routinely for HIV infection. Further studies are needed to address the high mortality.
  AIDS (London, England) 09/2009; 23(17):2309-16. · 4.91 Impact Factor
• Article: Efavirenz dose reduction to 200 mg once daily in a patient treated with rifampicin.

  Matthijs van Luin, Anne-Marie Brouwer, Andre van der Ven, Wiel de Lange, Ron H N van Schaik, David M Burger
  AIDS (London, England) 04/2009; 23(6):742-4. · 4.91 Impact Factor