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Jianxin Xue,
Lu Gan,
Xin Li,
Jian Li,
Guohai Qi,
Yalan Wu,
Xiaoyue Fu,
Qing Mao, Rui Ao,
Jingyi Lang,
You Lu
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ABSTRACT: Radiation pneumonitis (RP) is a serious complication of radiation therapy for thoracic tumors. Lysophosphatidic acid (LPA) and its receptors LPA⅓ were reported to participate in the processes of inflammation. We tested the hypothesis that LPA and its receptors LPA⅓, take part in the pathogenesis of RP. In our study, irradiation increased LPA levels in the lung and expression of LPA⅓. To further determine the role of LPA⅓, we performed pharmacological knockout of LPA⅓ by a specific antagonist, VPC-12249. On day 60 post-irradiation, RP was significantly alleviated in a dose-dependent manner in mice treated with VPC-12249, as shown by H&E staining, malondialdehyde (MDA, an indicator of oxidative damage) assay in lung, and concentrations of proinflammatory and profibrotic cytokines in plasma, including IL-1β, TNF-α, and TGF-β1. Additionally, VPC-12249 administration decreased the phosphorylation of IκB-α (the initial event that activates the NF-κB signal way), and expression of TGF-β1, CTGF, and α-SMA mRNA. Our findings suggest that LPA and LPA⅓ may play a pivotal role in RP, and LPA-LPA⅓ may serve as novel therapeutic targets for the treatment of RP.
Oncology Reports 12/2010; 24(6):1515-20. · 1.84 Impact Factor
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ABSTRACT: The aim of this study was to characterize the adverse events of attenuated measles vaccine in mainland China. We carried out prospective follow-up of adverse events after mass measles immunization practices, categorizing them into two groups: allergic reactions and serious adverse events. The incidence of anaphylaxis reaction was estimated to be 6.5 per million for attenuated measles vaccine. Among 14.3 million vaccination practices, 1 case each of acute disseminated encephalomyelitis (ADEM) and idiopathic thrombocytopenic purpura (ITP) and 28 cases of Henoch-Schonlein purpura (HSP) were reported. The total incidence of serious adverse events after vaccination was 2.14 per million doses.
Vaccine 11/2009; 29(18):3507-10. · 3.77 Impact Factor
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Fei Du,
Qing-lian Liu,
Qing-pei Fu,
Li Sun, Rui Ao,
Xu-jing Guan,
Yu Liu,
Jin Wang,
Hui He,
Wen-bin Tong,
Zhi-ying Qin,
Wen-jing Fan,
Jian Li,
Ji-lan He,
Gang Fang
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ABSTRACT: To understand the changes of hepatitis B infection rates, before and after the hepatitis B vaccine was included into EPI, and to evaluate the effect of immunization which would lead to the development of a more appropriate hepatitis B control strategy.
Seroepidemiologic method, with multi-section random sampling method were chosen. 14 sites from 8 counties were involved. 2-4 ml of the vein blood was drawn from all the individuals engaged in the study including 3806 samples. HBsAg, anti-HBs, anti-HBc of the samples were tested with ELISA.
Standardized positive rates of HBsAg and HBsAb were found as 7.05% and 29.77% respectively with the overall infection rate of HBV as 40.30%. The hepatitis B vaccine coverage of the children under 15 years was 70.73% and the positive rates for both HBsAg and anti-HBs were 2.62% and 56.68%, respectively. The coverage of hepatitis B vaccine among children under 3 years was 83.44% and the positive rates of both HBsAg and anti-HBs were 1.47% and 67.69% respectively, hepatitis B vaccine coverage of children under 3 years was 85.77%, with positive rates of HBsAg and anti-HBs as 1.78% and 75.44% respectively.
Results from our study revealed that since the introduction of hepatitis B vaccination, the prevalence rates of HBsAg and HBV infection had an obvious decline, especially in children aged under 15 years of old, suggesting that some changes had occurred in the epidemic characteristics of hepatitis B in Sichuan.
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 03/2009; 30(2):139-43.
