M Petrović

Klinički centar Srbije, Beograd, Central Serbia, Serbia

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Publications (265)159.12 Total impact

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    ABSTRACT: Multiple myeloma is a hemathological malignancy characterized by the clonal proliferation of plasma cells in the bone the marrow. Extramedullary dissemination of multiple myeloma is uncommon. In several cases only, the multiple myeloma malignant plasma cells had diseminated to the lung parenchyma.
    Vojnosanitetski pregled. Military-medical and pharmaceutical review 06/2014; 71(6):596-9. · 0.21 Impact Factor
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    ABSTRACT: A recurrent incisional hernia resulting from the rupture of low-weight polypropylene mesh is rarely reported in the literature. Three patients with recurrent incisional hernia due to low-weight polypropylene mesh central rupture were operated 5, 7 and 13 months after initial sublay hernioplasty. The posterior myofascial layer was fully reconstructed in all patients during the hernioplasty, whereas the anterior myofascial layer was only partially reconstructed. The recurrent hernia was managed using heavy-weight polypropylene mesh; in two patients, a new sublay hernioplasty was performed and in one patient an "open preperitoneal flat mesh technique" was performed under local anaesthesia as a day case procedure. If closing of the anterior myofascial layer cannot be ensured during the incisional hernioplasty, the use of low-weight polypropylene meshes should be avoided; preference should be given to the heavy-weight polypropylene meshes.
    Hernia 12/2013; · 1.69 Impact Factor
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    ABSTRACT: Renal artery stenosis (RAS) is narrowing of one or both renal arteries or their branches. Clinically sig nificant stenosis involves narrowing of the lumen, which is approximately 80%. The two most common causes of its occurrence are atherosclerosis and fibromuscular dyspla sia. Percutaneous transluminal renal angioplasty (PTRA) with stent implantation is an effective treatment modality that leads to lower blood pressure and improvement of kidney function. We presented 4 patients with significant stenosis of one or both renal arteries fol lowed by the development of arterial hypertension and re nal insufficiency. The causes of RAS were atherosclerosis in two patients and fibromuscular dysplasia in one patient. One of the patients had renal artery stenosis of trans planted kidney that developed 9 month after transplanta tion. In all the patients, in addition to clinical signs, dop pler screening suspected the existence of significant renal artery stenosis. The definitive diagnosis was made by ap plying computed tomographic angiography (CTA) of renal arteries in 3 of the patients and in 1 patient by percutaneus selective angiography. All the patients were treated by ap plication of PTRA with stent implantation followed by improvement/normalization of blood pressure and kidney function. Application of PTRA with stent implantation is an effective treatment of significant steno sis of one or both renal arteries followed by renal insuffi ciency.
    Vojnosanitetski pregled. Military-medical and pharmaceutical review 04/2013; 70(4):411-6. · 0.21 Impact Factor
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    ABSTRACT: Purpose: The aim of this study was to evaluate the clinical reliability of the immunoscintigraphy with iodinated monoclonal antibodies for the detection of metastases and recurrences of colon carcinomas. Methods: A total of 45 patients with colon carcinoma was investigated with gamma camera, after intravenous application of iodinated monoclonal antibodies. Results: The sensitivity of the method was 90%, specificity 86%, positive predictive value 93%, negative predictive value 80% and accuracy 87%. There was statistically significant relationship between immunoscintigraphic and ultrasonographic (US) findings (p=0.005). Also, there was significant relationship between immunoscintigraphy and Dukes stage (p=0.019). Tumor marker levels were not significantly correlated with immunoscintigraphic findings (p<0.05). Significant difference was noted in patients with positive findings for malignancy on US and immunoscintigraphic findings (p=0.006), i.e. patients with positive findings for malignancy had more frequently immunoscintigraphic findings of malignancy. Correlation with other diagnostic procedures (rectoscopy, colonoscopy, CT) did not show significant correlations. Conclusion: We conclude that immunoscintigraphy can be helpful in the detection of metastases and recurrences of colon carcinomas.
    Journal of B.U.ON.: official journal of the Balkan Union of Oncology 10/2012; 17(4):695-699. · 0.76 Impact Factor
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    ABSTRACT: In countries without a national organization for retrieval and distribution of organs of the deceased donors, problem of organ shortage is still not resolved. In order to increase the number of kidney transplantations we started with the program of living unrelated - spousal donors. The aim of this study was to compare treatment outcome and renal graft function in patients receiving the graft from spousal and those receiving ghe graft from living related donors. We retrospectively identified 14 patients who received renal allograft from spousal donors between 1996 and 2009 (group I). The control group consisted of 14 patients who got graft from related donor retrieved from the database and matched than with respect to sex, age, kidney disease, immunological and viral pretransplant status, the initial method of the end stage renal disease treatment and ABO compatibility. In the follow-up period of 41 +/- 38 months we recorded immunosuppressive therapy, surgical complications, episodes of acute rejection, CMV infection and graft function, assessed by serum creatinine levels at the beginning and in the end of the follow-up period. All patients had pretransplant negative cross-match. In ABO incompatible patients pretransplant isoagglutinine titer was zero. The patients with a spousal donor had worse HLA matching. There were no significant differences between the groups in surgical, infective, immunological complications and graft function. Two patients from the group I returned to hemodialysis after 82 and 22 months due to serious comorbidities. In spite of the worse HLA matching, graft survival and function of renal grafts from spousal donors were as good as those retrieved from related donors.
    Vojnosanitetski pregled. Military-medical and pharmaceutical review 12/2010; 67(12):998-1002. · 0.21 Impact Factor
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    M. Petrović, M. Belić, C. Denz, Y.S. Kivshar
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    ABSTRACT: Physics of counterpropagating optical beams and spatial optical solitons is reviewed, including the formation of stationary states and spatiotemporal instabilities. First, several models describing the evolution and interactions between optical beams and spatial solitons are discussed, that propagate in opposite directions in nonlinear media. It is shown that coherent collisions between counterpropagating beams give rise to an interesting focusing mechanism resulting from the interference between the beams, and that interactions between such beams are insensitive to the relative phase between them. Second, recent experimental observations of the counterpropagation effects and instabilities in waveguides and bulk geometries, as well as in one- and two-dimensional photonic lattices, are discussed. A variety of different generalizations of this concept are summarized, including the counterpropagating beams of complex structures, such as multipole beams and optical vortices, as well as the beams in different media, such as photorefractive materials and liquid crystals.
    Laser & Photonics Review 02/2010; 5(2):214 - 233. · 7.98 Impact Factor
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    ABSTRACT: Limited data exist in the literature regarding the effects of homocysteine thiolactone on the activity of the acetylcholinesterase (AChE) in the blood, and practically no data exist regarding the influence of homocysteine thiolactone on the enzyme in the brain and heart. Taking into consideration the importance of hyperhomocysteinemia in clinical practice, it has been thought to be of particular interest to examine the effect of homocysteine thiolactone on the activity of AChE in the rat's blood, brain and heart. In this study, male Wistar rats (weighing 250-300g) were used, and they were divided into two groups; one served as a control group and receieved a placebo (1 ml 0.9 % NaCl, i.p.), while the other group received a homocysteine thiolactone solution (5.5 mmol/kg b.m., i.p.). An hour after the administration, the rats were euthanized by decapitation, heir tissues were harvested, buff ered, and homogenized in a phosphate buff er (pH 8). The concentration in the tissue homogenates was 20 mg of tissue per 1 ml of buff er. The buffered and homogenized parts of the tissues were used as substrates for spectrophotometric measurements. The AChE activity was then measured by the Ellman method. Statistical analysis was conducted using a one-way ANOVA test, and the intergroup comparisons were performed using a Bonfferoni test. The results showed a significant reduction in AChE activity in all tissues obtained from the animals treated with homocysteine thiolactone compared to the enzyme activity of the control group. In addition, the results also showed that the blood enzyme activity inhibition was the lowest (12%), while the enzyme activity was slightly higher in the brain (27.8%) and heart specimens (86.3%). It was concluded that homocysteine thiolactone significantly inhibited AChE activity in the heart and brain tissue, but not in the blood of the rat.
    Serbian Journal of Experimental and Clinical Research 01/2010; 11(1):19-22.
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    ABSTRACT: Various studies have shown that the serum concentration of folic acid is inversely related to the serum homocysteine concentration. In addition, data suggest that increases in serum homocysteine levels decrease the activity of acetylcholinesterase (AChE). The aim of this study was to investigate the effects of acute folic acid treatment on AChE activity in the brain, heart and the blood of a rat. We used male Wistar rats, with a body mass of 250-300 g divided into two categories: a control group given placebo (1 ml 0.9% NaCl, i.p. n1=6) and an experimental group treated with folic acid (1 ml 0.011 μmol/g per body mass, pH 7.4, i.p., n2=6). Sixty minutes after the treatment, the rats were decapitated. T e brain and the heart were removed, and blood was taken. The brain and heart were homogenised in phosphate buffer pH=8 (1 ml buffer/20 mg tissue). The homogenised tissues and blood were used as a substrate for the spectrophotometric analysis, and enzyme activity was measured in vitro by the Ellman method. Rats treated with folic acid showed signifi -cantly reduced AChE activity in the brain and blood compared to the control group (38% and 82%, respectively). We did not observe a significant difference between the enzyme activity in the blood of treated versus untreated rats. In conclusion, this study shows that acute treatment with folic acid decreases the AChE activity in the brain and heart of rats without affecting the AChE activity in the blood.
    Serbian Journal of Experimental and Clinical Research 01/2010; 10(3):85-88.
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    ABSTRACT: Dynamical and steady-state behavior of beams propagating in nematic liquid crystals (NLCs) is analyzed. A well-known model for the beam propagation and the director reorientation angle in a NLC cell is treated numerically in space and time. The formation of steady-state soliton breathers in a threshold region of beam intensities is displayed. Below the region the beams diffract, above the region spatiotemporal instabilities develop, as the input intensity and the material parameters are varied. Curiously, the only kind of solitons we could demonstrate in our numerical studies was the breathers. Despite repeated efforts, we could not find the solitons with a steady profile propagating in the NLC model at hand.
    Optics Express 08/2009; 17(14):11698-709. · 3.55 Impact Factor
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    ABSTRACT: Systemic lupus erythematodes (SLE) is chronic, often febrile, multisystemic disease unknown origin and relapsing course which affects connective tissue of the skin, joints, kidney and serous membranes. Gastrointestinal manifestations are rarely the first sign of systemic lupus erythematosus. We presented a female patient, 35 years old, whose first symptoms of SLE were paralitic ileus (chronic intestinal pseudo-obstruction) and polyserositis (pleural effusion and ascites). Except for high parameters of inflammation, leucopenia and thrombocytopenia, all immunological and laboratory tests for SLE were negative in the onset of the disease. During next six months the patient had clinical signs of paralitic ileus several times and was twice operated with progressive malabsorptive syndrome. The full picture of SLE was manifested seven months later associated with lupus nephritis. Treatment with cyclophosphamide, corticosteroids and total parenteral nutrition (30 days) induced stable remission of the disease. The SLE can be initially manifested with gastroenterological symptoms without any other clinical and immunologic parameters of the disease. If in patients with SLE and gastrointestinal tract involvement malabsorption syndrom is developed, a treatment success depends on both immunosupressive therapy and total parenteral nutrition.
    Vojnosanitetski pregled. Military-medical and pharmaceutical review 04/2009; 66(3):238-41. · 0.21 Impact Factor
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    ABSTRACT: Hemorrhagic fever with renal syndrome (HFRS) is acute infective multisystemic disease followed by febrility, hemorrhages and acute renal insufficiency. Bleeding in the anterior pituitary lobe leading to tissue necrosis occurs in acute stage of severe clinical forms of HFRS, while atrophy of the anterior pituitary lobe with diminution of the gland function occurs after recovery stage. We presented a patient with the development of chronic renal insufficiency and hypopituitarism as complication that had been diagnosed six years after Hantavirus infection. Magnetic resonance of the pituitary gland revealed atrophy and empty sella turcica. Regarding frequency of this viral infection and its endemic character in some parts of our country partial and/or complete loss of pituitary function should be considered during the late stage of HFRS.
    Vojnosanitetski pregled. Military-medical and pharmaceutical review 03/2009; 66(2):166-8. · 0.21 Impact Factor
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    01/2009;
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    ABSTRACT: essential contribution to the quality of pasture and meadow communities and soil fertility. Among such are narrow-leafed vetch (V. sativa subsp. nigra (L.) Ehrh.), large-flowered vetch (V. grandiflora Scop.), hairy vetch (V. villosa Roth), Hungarian vetch (V. pannonica Crantz) and tiny vetch (V. hirsuta (L.) Gray). As crude pro- tein concentration in dry matter is more than 200 g/kg, these vetch species are richer in N than other forage legumes such as lucerne or pea and are able to answer the demands for a quality source of both forage and green manure. Long-term programmes on annual legume genetic resources in Slovakia and Serbia have been articulated through a bilateral project Conservation of the Genetic Resources of Annual Forage and Grain Legumes in Slovakia and Serbia (2008-2009), with emphasis on vetches. As the initial step, wild populations of many vetch species, with emphasis upon narrow-leafed, large-flowered, hairy, Hungarian and tiny vetches, have been mapped, described and conserved ex situ in the form of herbarium and seed samples. The collected seed mate- rial has been multiplied and each accession entered the processes of characterization, with emphasis upon leaf and seed morphology, and evaluation of forage and seed yields and forage dry matter chemical composition. One of the outcomes is the selection of the lines with desirable characteristics and their improvement by breeding into advanced varieties, suitable for forage production and green manure. The wild populations of all examined vetch species show a wide variability of forage yield and seed yield components. Hairy vetch has potential for 50 t/ha of green forage and 12 t/ha of forage dry matter, while large- flowered vetch may produce more than 40 t/ha of green forage and nearly 14 t/ha of forage dry matter (Mikic ´ et al., 2009). Due to a less prominent pod dehiscence, Hungarian vetch has the potential to increase seed pro- duction. Certain wild populations, especially of large-flowered and hairy vetches, may produce up to 400 kg/ha of forage N, apart from N accumulated by roots. Common to all examined wild vetch species is an excellent temperature tolerance, with an average absolute minimum of near −20 °C in some years. Additionally, when sown in late September, all reach the optimal stage to be cut for forage in April and thus leave enough time for the next main crop such as maize, forage sorghum or Sudan grass.
    01/2009;
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    A. Strinic, M. Petrovic, Belic
    Acta Physica Polonica Series a 01/2009; 116. · 0.53 Impact Factor
  • R. Kastori, M. Petrović, N. Petrović
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    ABSTRACT: The effect of excess concentrations of lead (Pb), cadmium (Cd), copper (Cu), and zinc (Zn) on water relations in young sunflower (Helianthus annuus L.) plants was studied in water culture under greenhouse conditions. The accumulation of the heavy metals was more intensive in the root than in the shoot. The rates of heavy metal accumulation in root were arranged in the following decreasing order: Cu, Cd, Zn, and Pb. Their transport into the above‐ground parts followed the order: Zn, Cu, Pb, and Cd. Transpiration and relative water content were significantly decreased by excess concentrations of the heavy metals. The number of stomata per unit leaf area was increased while the size of the stomata was decreased. The concentration of free proline significantly increased in the leaves of intact plants as well as in leaf discs incubated in the presence of heavy metals. The concentration of soluble proteins decreased as well, particularly when plants were exposed to high concentrations of the heavy metals. It was concluded that excess concentrations of the heavy metals significantly affected plant water status, causing water deficit and subsequent changes in the plants. The most intensive effect on the plants was exerted by Cd, less intensive by Cu and Zn and the least intensive by Pb.
    Journal of Plant Nutrition. 11/2008; 15(11):2427-2439.
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    ABSTRACT: The most frequent method for the assessment of glomerular filtration rate GFR) in clinical practice is clearance of creatinine, clearance of chromium-51 radiolabelled ethylene diamine tetraacetic acid (51Cr-EDTA) and clearance of technetium-99m radiolabelled diethylene triamine pentaacetic acid (99mTc-DTPA). The Gates method for glomerular filtration rate assessment is based on distribution of 99mTc-DTPA in the kidney 2-3 minute after its applying. Calculation of GFR is corrected for the background and depth of the kidney and finally expressed as a percentage of the net injected counts. This value of GFR highly correlates with biexponential model as the most accurate method for the assessment of GFR. The aim of this study was to determine the influence of different background sites on GFR rate assessment using the Gates method. We analysed 50 patients who were divided into two groups: the group of healthy subjects (21 subjects, mean age 47.38 yrs) and the group of subjects with unilateral kidney damage (29 subjects, mean age 39.79 yrs). Three different background activity regions were chosen: a region drawn below the lower pole of each kidney, region drawn by the lateral side of each kidney and region drawn around the whole kidney. Gromerular filtration rate calculated by the use of a region under the lower pole is statistically significantly higher than GFR calculated using a region by the lateral side and around the whole kidney (p < 0.0001). Glomerular filtration rate calculated using the region by the lateral side and region around the whole kidney did not show statistically significant difference (p > 0.05). The selection of background activity region has a significant influence on GFR rate measured by the Gates method. It is recommended to use only one method for choosing the region of background activity.
    Vojnosanitetski pregled. Military-medical and pharmaceutical review 11/2008; 65(10):729-32. · 0.21 Impact Factor
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    ABSTRACT: A key role of hsp90 in the activity of various oncogenic proteins and pathways is currently of intense interest. To clarify the molecular basis of biological behaviour of colorectal cancers we analysed the expression characteristics of hsp90 in cytosolic, nuclear and plasma membranous fractions of cancer cells. As determined by Western blot assay all hsp90 isoforms studied, alpha (84 kDa), beta (86 kDa) and hsp90N (75 kDa), were up-regulated and differentially expressed in various stages of colorectal carcinoma. The inducible hsp90alpha isoform is a component of invasive phenotype of cancer cells thus pointing to the importance of hsp90alpha for metastasis generation. The expression of hsp90beta is definitely higher in poorly-differentiated carcinomas than in well-differentiated cancers, suggesting an involvement of hsp90beta in the inhibition of cancer cell differentiation. Especially, the expression of cytosolic hsp90N isoform in malignant cells points to the possibility that induction or overexpression of hsp90N might be causally related to tumour formation. Hsp90N is the plasma-membrane-associated protein in poorly-differentiated colorectal cancers with metastasis. This suggests that the expression of hsp90N is elevated with progressive dedifferentiation often associated with advanced cancer stages. Hsp90 was exclusively localized in the invasive front in a majority of metastatic cancers as visualized by immunohistochemical study. Consistent with these facts, the frequent expression of hsp90alpha and hsp90N on the surface of colorectal cancer cells may enable hsp90 to act as a mediator of metastasis generation. The above results indicate more complex roles for hsp90 in colorectal tumourigenesis. In this way, the hsp90 would be at the crossroads of both signalling and cell migration events.
    International Journal of Oncology 07/2008; 32(6):1169-78. · 2.66 Impact Factor
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    ABSTRACT: Paragangliomas are tumors arising from the extra-adrenal paragangliar neural crest cells. The sympathoadrenal neuroendocrine system consists of extra-adrenal paragangliar cellular layer along the paravertebral and para-aortic axis, and the adrenal medullae. Paraganglioma should be included in the differential diagnosis of secondary erythrocytosis due to its possible ectopic erythropoietin (EPO) secretion. Thus, in this report we present a 24-year-old female patient with onset of unregulated ectopic EPO secretion, and consecutive erythrocytosis followed by hypertension, secondary to paraganglioma of multifocal retroperitoneal localization. Clinical, laboratory, and radiological investigations confirmed both an elevated EPO level and the presence of multiple paraganglioma. This paraneoplastic-mediated medical condition with high risk of cellular hyperviscosity syndrome (CHVS) requires prompt diagnosis and rapid therapeutic interventions. Initially, simple phlebotomy procedures were used; following that, tumors were surgically removed. In the course of the disease, this tumor relapsed, and urgent apheresis, as a treatment of life-threatening state, was used. The therapy performed resulted in a rapid blood viscosity depletion and a significant (P < 0.01) serum EPO reduction, as well as the general clinical benefit. Therefore, we conclude that the use of our own "multi-manner" apheresis (erythrocythapheresis plus plasma exchange), for long-time interval (until further causative therapy), effectively cross-bridged the possible hazards of EPO-dependent CHVS.
    Medical Oncology 01/2008; 25(2):148-53. · 2.15 Impact Factor
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    ABSTRACT: While the general prognostic factors for colorectal carcinoma have been widely researched, the compound relationships between tumor characteristics and development of colorectal liver metastases have not been clearly understood. The aim of this study was to determine which histopathological characteristics of colorectal cancer may be associated with subsequent development of colorectal liver metastases. We performed retrospective and prospective study which included 80 patients operated for colorectal carcinoma on the First Surgical Clinic of Clinical Center of Serbia in Belgrade. Retrospective group consisted of 40 patients operated between 1992. and 1996. while prospective group included 40 patients treated between 1997. and 2001. We analyzed the size of the tumor, depth of invasion through the intestinal wall, extramural spread of the tumor, infiltration of blood vessels and lymphatics, lymph node involvement, tumor maturation and growth, as well circumferential intestinal involvement. Statistical analysis performed showed highly significant (p<0,01) correlation between the tumor size, degree of maturation of the tumor, extramural spread and involvement of the venules with later development of colorectal liver metastases in both groups.
    Acta chirurgica iugoslavica 01/2008; 55(4):27-30.

Publication Stats

370 Citations
159.12 Total Impact Points

Institutions

  • 1998–2012
    • Klinički centar Srbije
      • Institute of Haematology
      Beograd, Central Serbia, Serbia
    • Vojna akademija Beograd
      Beograd, Central Serbia, Serbia
  • 2009–2010
    • Texas A&M University at Qatar
      Ad Dawḩah, Ad Dawḩah, Qatar
    • Institut za stočarstvo, Beograd-Zemun
      Beograd, Central Serbia, Serbia
  • 2008
    • Institute of Field and Vegetable Crops
      Varadinum Petri, Autonomna Pokrajina Vojvodina, Serbia
  • 2004
    • Institute for Educational Research, Belgrade, Serbia
      Beograd, Central Serbia, Serbia
  • 2001
    • Roche Institute of Molecular Biology
      Nutley, New Jersey, United States
  • 1988–2000
    • Institute for Medical Research - Belgrade
      Beograd, Central Serbia, Serbia
  • 1996–1997
    • Institute of Physics Belgrade
      Beograd, Central Serbia, Serbia
    • Technical University Darmstadt
      • Institut für Kernphysik
      Darmstadt, Hesse, Germany
    • Military Medical Academy
      Beograd, Central Serbia, Serbia
  • 1993–1996
    • University of Belgrade
      • Institute of Nuclear Medicine
      Beograd, Central Serbia, Serbia
  • 1989
    • The American Society for Biochemistry and Molecular Biology
      Belgrade, Montana, United States