M Petrović

Military Medical Academy, Beograd, Central Serbia, Serbia

Are you M Petrović?

Claim your profile

Publications (287)186.15 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Multiple myeloma is a hemathological malignancy characterized by the clonal proliferation of plasma cells in the bone the marrow. Extramedullary dissemination of multiple myeloma is uncommon. In several cases only, the multiple myeloma malignant plasma cells had diseminated to the lung parenchyma.
    Vojnosanitetski pregled. Military-medical and pharmaceutical review 06/2014; 71(6):596-9. · 0.21 Impact Factor
  • Source
  • [Show abstract] [Hide abstract]
    ABSTRACT: A recurrent incisional hernia resulting from the rupture of low-weight polypropylene mesh is rarely reported in the literature. Three patients with recurrent incisional hernia due to low-weight polypropylene mesh central rupture were operated 5, 7 and 13 months after initial sublay hernioplasty. The posterior myofascial layer was fully reconstructed in all patients during the hernioplasty, whereas the anterior myofascial layer was only partially reconstructed. The recurrent hernia was managed using heavy-weight polypropylene mesh; in two patients, a new sublay hernioplasty was performed and in one patient an "open preperitoneal flat mesh technique" was performed under local anaesthesia as a day case procedure. If closing of the anterior myofascial layer cannot be ensured during the incisional hernioplasty, the use of low-weight polypropylene meshes should be avoided; preference should be given to the heavy-weight polypropylene meshes.
    Hernia 12/2013; · 1.69 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Renal artery stenosis (RAS) is narrowing of one or both renal arteries or their branches. Clinically sig nificant stenosis involves narrowing of the lumen, which is approximately 80%. The two most common causes of its occurrence are atherosclerosis and fibromuscular dyspla sia. Percutaneous transluminal renal angioplasty (PTRA) with stent implantation is an effective treatment modality that leads to lower blood pressure and improvement of kidney function. We presented 4 patients with significant stenosis of one or both renal arteries fol lowed by the development of arterial hypertension and re nal insufficiency. The causes of RAS were atherosclerosis in two patients and fibromuscular dysplasia in one patient. One of the patients had renal artery stenosis of trans planted kidney that developed 9 month after transplanta tion. In all the patients, in addition to clinical signs, dop pler screening suspected the existence of significant renal artery stenosis. The definitive diagnosis was made by ap plying computed tomographic angiography (CTA) of renal arteries in 3 of the patients and in 1 patient by percutaneus selective angiography. All the patients were treated by ap plication of PTRA with stent implantation followed by improvement/normalization of blood pressure and kidney function. Application of PTRA with stent implantation is an effective treatment of significant steno sis of one or both renal arteries followed by renal insuffi ciency.
    Vojnosanitetski pregled. Military-medical and pharmaceutical review 04/2013; 70(4):411-6. · 0.21 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Purpose: The aim of this study was to evaluate the clinical reliability of the immunoscintigraphy with iodinated monoclonal antibodies for the detection of metastases and recurrences of colon carcinomas. Methods: A total of 45 patients with colon carcinoma was investigated with gamma camera, after intravenous application of iodinated monoclonal antibodies. Results: The sensitivity of the method was 90%, specificity 86%, positive predictive value 93%, negative predictive value 80% and accuracy 87%. There was statistically significant relationship between immunoscintigraphic and ultrasonographic (US) findings (p=0.005). Also, there was significant relationship between immunoscintigraphy and Dukes stage (p=0.019). Tumor marker levels were not significantly correlated with immunoscintigraphic findings (p<0.05). Significant difference was noted in patients with positive findings for malignancy on US and immunoscintigraphic findings (p=0.006), i.e. patients with positive findings for malignancy had more frequently immunoscintigraphic findings of malignancy. Correlation with other diagnostic procedures (rectoscopy, colonoscopy, CT) did not show significant correlations. Conclusion: We conclude that immunoscintigraphy can be helpful in the detection of metastases and recurrences of colon carcinomas.
    Journal of B.U.ON.: official journal of the Balkan Union of Oncology 10/2012; 17(4):695-699. · 0.76 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Cognitive impairment is present in up to 65 % of multiple sclerosis (MS) patients. The Brief Repeatable Battery of neuropsychological tests (BRB) is one of the most used neuropsychological tools for cognitive assessment in MS. However, relative lack of normative data limits its application in research and clinical practice. In order to obtain normative data for a Serbian population, we administered the BRB version A to 140 healthy subjects and assessed the influence of demographic factors such as gender, age, and education on the tests' scores. We also calculated corrections for these factors. Higher education was associated with better performance on all the tests. Age influenced all the tests, except the word list generation, higher age being associated with worse performance on all other tests. Women performed worse on the paced auditory serial addition test 2, no other gender differences were observed. Our data obtained for the Serbian population could further improve use of the BRB in clinical practice and for the research purposes, establishing cognitive evaluation as a part of standard neurological examination of MS patients.
    Neurological Sciences 05/2012; · 1.41 Impact Factor
  • International journal of cardiology 02/2012; 156(2):219-21. · 6.18 Impact Factor
  • International Journal of Clinical Practice 11/2011; 65(11):1202-3. · 2.43 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Acute heart failure (AHF) is one of the most common diseases in emergency medicine, associated with poor prognosis and high in-hospital and long-term mortality. The aim of this study was to investigate characteristics, outcomes and one year mortality of patients with AHF in the local population. This prospective study consisted of 64 consecutive unselected patients treated in the Coronary Care Unit of the Emergency Centre (Clinical Center of Serbia, Belgrade) and were followed for one year after the discharge. Mean age of the patients was 63.6 +/- 12.6 years and 59.4% were males. Acute congestion (43.8%) and pulmonary edema (39.1%) were the most common presentations of AHF. Mean left ventricular ejection fraction (LVEF) was 39.7% +/- 9.25%, while 44.4% of the patients had LVEF > or = 50%. At discharge, 55.9% of the patients received therapy with P-blockers, 94.9% diuretics, out of which 47.7% spironolactone, 94.9% patients were given ACE-inhibitors or angiotensin receptor blockers (ARB). The 12-month all-cause mortality was 26.5%. Independent predictors of one year mortality were previous hospitalization due to heart disease, reduced LVEF, reduced fraction of shortening (FS) and a higher tricuspid velocity. One year mortality of our patients with AHF was high, similar to the known European studies. Independent predictors of one year mortality were previous hospitalization due to heart disease, reduced LVEF and LVFS and a higher tricuspid velocity.
    Vojnosanitetski pregled. Military-medical and pharmaceutical review 02/2011; 68(2):136-42. · 0.21 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: In countries without a national organization for retrieval and distribution of organs of the deceased donors, problem of organ shortage is still not resolved. In order to increase the number of kidney transplantations we started with the program of living unrelated - spousal donors. The aim of this study was to compare treatment outcome and renal graft function in patients receiving the graft from spousal and those receiving ghe graft from living related donors. We retrospectively identified 14 patients who received renal allograft from spousal donors between 1996 and 2009 (group I). The control group consisted of 14 patients who got graft from related donor retrieved from the database and matched than with respect to sex, age, kidney disease, immunological and viral pretransplant status, the initial method of the end stage renal disease treatment and ABO compatibility. In the follow-up period of 41 +/- 38 months we recorded immunosuppressive therapy, surgical complications, episodes of acute rejection, CMV infection and graft function, assessed by serum creatinine levels at the beginning and in the end of the follow-up period. All patients had pretransplant negative cross-match. In ABO incompatible patients pretransplant isoagglutinine titer was zero. The patients with a spousal donor had worse HLA matching. There were no significant differences between the groups in surgical, infective, immunological complications and graft function. Two patients from the group I returned to hemodialysis after 82 and 22 months due to serious comorbidities. In spite of the worse HLA matching, graft survival and function of renal grafts from spousal donors were as good as those retrieved from related donors.
    Vojnosanitetski pregled. Military-medical and pharmaceutical review 12/2010; 67(12):998-1002. · 0.21 Impact Factor
  • Source
    M. Petrović, M. Belić, C. Denz, Y.S. Kivshar
    [Show abstract] [Hide abstract]
    ABSTRACT: Physics of counterpropagating optical beams and spatial optical solitons is reviewed, including the formation of stationary states and spatiotemporal instabilities. First, several models describing the evolution and interactions between optical beams and spatial solitons are discussed, that propagate in opposite directions in nonlinear media. It is shown that coherent collisions between counterpropagating beams give rise to an interesting focusing mechanism resulting from the interference between the beams, and that interactions between such beams are insensitive to the relative phase between them. Second, recent experimental observations of the counterpropagation effects and instabilities in waveguides and bulk geometries, as well as in one- and two-dimensional photonic lattices, are discussed. A variety of different generalizations of this concept are summarized, including the counterpropagating beams of complex structures, such as multipole beams and optical vortices, as well as the beams in different media, such as photorefractive materials and liquid crystals.
    Laser & Photonics Review 02/2010; 5(2):214 - 233. · 7.98 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Limited data exist in the literature regarding the effects of homocysteine thiolactone on the activity of the acetylcholinesterase (AChE) in the blood, and practically no data exist regarding the influence of homocysteine thiolactone on the enzyme in the brain and heart. Taking into consideration the importance of hyperhomocysteinemia in clinical practice, it has been thought to be of particular interest to examine the effect of homocysteine thiolactone on the activity of AChE in the rat's blood, brain and heart. In this study, male Wistar rats (weighing 250-300g) were used, and they were divided into two groups; one served as a control group and receieved a placebo (1 ml 0.9 % NaCl, i.p.), while the other group received a homocysteine thiolactone solution (5.5 mmol/kg b.m., i.p.). An hour after the administration, the rats were euthanized by decapitation, heir tissues were harvested, buff ered, and homogenized in a phosphate buff er (pH 8). The concentration in the tissue homogenates was 20 mg of tissue per 1 ml of buff er. The buffered and homogenized parts of the tissues were used as substrates for spectrophotometric measurements. The AChE activity was then measured by the Ellman method. Statistical analysis was conducted using a one-way ANOVA test, and the intergroup comparisons were performed using a Bonfferoni test. The results showed a significant reduction in AChE activity in all tissues obtained from the animals treated with homocysteine thiolactone compared to the enzyme activity of the control group. In addition, the results also showed that the blood enzyme activity inhibition was the lowest (12%), while the enzyme activity was slightly higher in the brain (27.8%) and heart specimens (86.3%). It was concluded that homocysteine thiolactone significantly inhibited AChE activity in the heart and brain tissue, but not in the blood of the rat.
    Serbian Journal of Experimental and Clinical Research 01/2010; 11(1):19-22.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Various studies have shown that the serum concentration of folic acid is inversely related to the serum homocysteine concentration. In addition, data suggest that increases in serum homocysteine levels decrease the activity of acetylcholinesterase (AChE). The aim of this study was to investigate the effects of acute folic acid treatment on AChE activity in the brain, heart and the blood of a rat. We used male Wistar rats, with a body mass of 250-300 g divided into two categories: a control group given placebo (1 ml 0.9% NaCl, i.p. n1=6) and an experimental group treated with folic acid (1 ml 0.011 μmol/g per body mass, pH 7.4, i.p., n2=6). Sixty minutes after the treatment, the rats were decapitated. T e brain and the heart were removed, and blood was taken. The brain and heart were homogenised in phosphate buffer pH=8 (1 ml buffer/20 mg tissue). The homogenised tissues and blood were used as a substrate for the spectrophotometric analysis, and enzyme activity was measured in vitro by the Ellman method. Rats treated with folic acid showed signifi -cantly reduced AChE activity in the brain and blood compared to the control group (38% and 82%, respectively). We did not observe a significant difference between the enzyme activity in the blood of treated versus untreated rats. In conclusion, this study shows that acute treatment with folic acid decreases the AChE activity in the brain and heart of rats without affecting the AChE activity in the blood.
    Serbian Journal of Experimental and Clinical Research 01/2010; 10(3):85-88.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Introduction. Acute heart failure (AHF) is one of the most common diseases in emergency medicine, associated with poor prognosis and high in-hospital and long-term mortality. Objective. To investigate clinical presentation of patients with de novo AHF and acute worsening of chronic heart failure (CHF) and to identify differences in blood levels of biomarkers and echocardiography findings. Methods. This prospective study comprised 64 consecutive patients being grouped according to the onset of the disease into patients with the de novo AHF (45.3%), and patients with acute worsening of CHF (54.7%). Results. Acute congestion (60%) was the most common manifestation of de novo AHF, whereas pulmonary oedema (43.1%) was the most common manifestation of acutely decompensated CHF. Patients with acutely decompensated CHF had significantly higher blood values of creatinine (147.10 vs 113.16 μmol/l; p<0.05), urea (12.63 vs 7.82 mmol/l; p<0.05), BNP (1440.11 vs 712.24 pg/ml; p<001) and NTproBNP (9097.00 vs 2827.70 pg/ml; p<0.01) on admission, and lower values of M-mode left ventricular ejection fraction (LVEF) during hospitalization (49.44% vs 42.94%; p<0.05). The follow-up after one year revealed still significantly higher BNP (365.49 vs 164.02 pg/ ml; p<0.05) and lower average values of both LVEF in patients with acutely worsened CHF (46.62% vs 54.41% and 39.52% vs 47.88%; p<0.05). Conclusion. Considering differences in clinical severity on admission, echocardiography and natriuretic peptide values during hospitalization and after one year follow-up, de novo AHF and acutely worsened CHF are two different subgroups of the same syndrome.
    Srpski arhiv za celokupno lekarstvo 01/2010; · 0.23 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Introduction. Paroxysmal atrial fibrillation (AF) occurs in 11.5-39% of the patients with Wolff-Parkinson-White (WPW) syndrome and frequently, but not always, disappears after successful accessory pathway (AP) ablation. Objective. To determine AF recurrence rate, time to AF recurrence and predictors of AF recurrence after radiofrequency (RF) catheter-ablation of AP in WPW-patients with AF. Methods. Data from 245 consecutive patients with WPW-syndrome who underwent RF catheter-ablation of AP were analyzed. A total of 52 patients (43 men, mean age: 42.5±14.1 years) with preablation history of spontaneous AF were followed up after definitive AP ablation. At baseline, structural heart disease and comorbidities were diagnosed in 19.2% and 21.2% of the patients, respectively. Results. During the follow-up of 5.2±3.7 years, 3 patients (5.7%) died; one of these patients, previously known for recurrent AF, died from ischaemic stroke. Symptomatic recurrence of AF was detected in 9 of 52 patients (17.3%). In 66.7% of these patients, AF recurrence was identified in the first year following the procedure. Kaplan-Meier analysis demonstrated that freedom from recurrent AF after 3 months was 94.2%, after 1 year 87.5% and after 4 years 84.3%. Univariate analysis showed that older age (p=0.023), presence of structural heart disease (p=0.05) and dilated left atrium (p=0.013) were significantly related to AF recurrence. However, using multivariate Cox regression, older age was the only independent predictor of AF recurrence (HR=2.44 for every life decade; p=0.006). Analysis of ROC curves showed that, after the age of 36, the risk of AF recurrence abruptly increased. Conclusion. Symptomatic recurrence of AF was detected in 17% of WPW-patients after definite RF ablation of AP. The timedependent occurrence of AF recurrences and age-dependent increase in the rate of AF recurrence were identified. Closer follow-up and/or extension of drug therapy in older patients, at least in the first year after the procedure, seem prudent.
    Srpski arhiv za celokupno lekarstvo 01/2010; · 0.23 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Export Date: 18 October 2014
    Periodicum Biologorum 01/2010; 112(2):167-171. · 0.20 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: To evaluate the clinical characteristics of splenic marginal-zone lymphoma (SMZL) following antigen expression and the influence of therapeutic approaches on clinical outcome and overall survival (OS). A total of 30 patients with typical histological and immunohistochemical SMZL patterns were examined. Splenectomy plus chemotherapy was applied in 20 patients, while splenectomy as a single treatment-option was performed in 10 patients. Prognostic factor and overall survival rate were analyzed. Complete remission (CR) was achieved in 20 (66.7%), partial remission (PR) in seven (23.3%), and lethal outcome due to disease progression occurred in three (10.0%) patients. Median survival of patients with a splenectomy was 93.0 mo and for patients with splenectomy plus chemotherapy it was 107.5 mo (Log rank = 0.056, P > 0.05). Time from onset of first symptoms to the beginning of the treatment (mean 9.4 mo) was influenced by spleen dimensions, as measured by computerized tomography and ultra-sound (t = 2.558, P = 0.018). Strong positivity (+++) of CD20 antigen expression in splenic tissue had a positive influence on OS (Log rank = 5.244, P < 0.05). The analysis of factors interfering with survival (by the Kaplan-Meier method) revealed that gender, general symptoms, clinical stage, and spleen infiltration type (nodular vs diffuse) had no significant (P > 0.05) effects on the OS. The expression of other antigens (immunohistochemistry) also had no effect on survival-rate, as measured by a c2 test (P > 0.05). Initial splenectomy combined with chemotherapy has been shown to be beneficial due to its advanced remission rate/duration; however, a larger controlled clinical study is required to confirm our findings.
    World Journal of Gastroenterology 09/2009; 15(32):4009-15. · 2.55 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Dynamical and steady-state behavior of beams propagating in nematic liquid crystals (NLCs) is analyzed. A well-known model for the beam propagation and the director reorientation angle in a NLC cell is treated numerically in space and time. The formation of steady-state soliton breathers in a threshold region of beam intensities is displayed. Below the region the beams diffract, above the region spatiotemporal instabilities develop, as the input intensity and the material parameters are varied. Curiously, the only kind of solitons we could demonstrate in our numerical studies was the breathers. Despite repeated efforts, we could not find the solitons with a steady profile propagating in the NLC model at hand.
    Optics Express 08/2009; 17(14):11698-709. · 3.55 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Systemic lupus erythematodes (SLE) is chronic, often febrile, multisystemic disease unknown origin and relapsing course which affects connective tissue of the skin, joints, kidney and serous membranes. Gastrointestinal manifestations are rarely the first sign of systemic lupus erythematosus. We presented a female patient, 35 years old, whose first symptoms of SLE were paralitic ileus (chronic intestinal pseudo-obstruction) and polyserositis (pleural effusion and ascites). Except for high parameters of inflammation, leucopenia and thrombocytopenia, all immunological and laboratory tests for SLE were negative in the onset of the disease. During next six months the patient had clinical signs of paralitic ileus several times and was twice operated with progressive malabsorptive syndrome. The full picture of SLE was manifested seven months later associated with lupus nephritis. Treatment with cyclophosphamide, corticosteroids and total parenteral nutrition (30 days) induced stable remission of the disease. The SLE can be initially manifested with gastroenterological symptoms without any other clinical and immunologic parameters of the disease. If in patients with SLE and gastrointestinal tract involvement malabsorption syndrom is developed, a treatment success depends on both immunosupressive therapy and total parenteral nutrition.
    Vojnosanitetski pregled. Military-medical and pharmaceutical review 04/2009; 66(3):238-41. · 0.21 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Hemorrhagic fever with renal syndrome (HFRS) is acute infective multisystemic disease followed by febrility, hemorrhages and acute renal insufficiency. Bleeding in the anterior pituitary lobe leading to tissue necrosis occurs in acute stage of severe clinical forms of HFRS, while atrophy of the anterior pituitary lobe with diminution of the gland function occurs after recovery stage. We presented a patient with the development of chronic renal insufficiency and hypopituitarism as complication that had been diagnosed six years after Hantavirus infection. Magnetic resonance of the pituitary gland revealed atrophy and empty sella turcica. Regarding frequency of this viral infection and its endemic character in some parts of our country partial and/or complete loss of pituitary function should be considered during the late stage of HFRS.
    Vojnosanitetski pregled. Military-medical and pharmaceutical review 03/2009; 66(2):166-8. · 0.21 Impact Factor

Publication Stats

389 Citations
186.15 Total Impact Points

Institutions

  • 1996–2012
    • Military Medical Academy
      Beograd, Central Serbia, Serbia
    • Technical University Darmstadt
      • Institut für Kernphysik
      Darmstadt, Hesse, Germany
  • 1993–2011
    • University of Belgrade
      • Institute of Nuclear Medicine
      Beograd, Central Serbia, Serbia
  • 2009–2010
    • Texas A&M University at Qatar
      Ad Dawḩah, Ad Dawḩah, Qatar
    • Institut za stočarstvo, Beograd-Zemun
      Beograd, Central Serbia, Serbia
  • 2008
    • Institute of Field and Vegetable Crops
      Varadinum Petri, Autonomna Pokrajina Vojvodina, Serbia
  • 1998–2008
    • Klinički centar Srbije
      • • Institute of Haematology
      • • Institute for Cardiovascular Diseases
      Beograd, Central Serbia, Serbia
    • Vojna akademija Beograd
      Beograd, Central Serbia, Serbia
  • 2003–2004
    • Institute for Educational Research, Belgrade, Serbia
      Beograd, Central Serbia, Serbia
  • 2001
    • Roche Institute of Molecular Biology
      Nutley, New Jersey, United States
  • 1988–2000
    • Institute for Medical Research - Belgrade
      Beograd, Central Serbia, Serbia
  • 1996–1997
    • Institute of Physics Belgrade
      Beograd, Central Serbia, Serbia
  • 1989
    • The American Society for Biochemistry and Molecular Biology
      Belgrade, Montana, United States