Publications (1)0 Total impact
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ABSTRACT: The synthesis and oral bioavailability of two potential prodrugs of Ganciclovir (1) based on the “trimethyl lock” is described. The mono-3-(2′-Acetoxy-4′6′-dimethylphenyl)-3,3-dimethylpropanoic ester (2) showed a four-fold increase in oral bioavailability over the parent drug in rats.Bioorganic & Medicinal Chemistry Letters. 01/1996; 6(14):1653-1656.