S Y Nam

Publications (2)8.98 Total impact

• Article: Risk of hemorrhagic gastropathy associated with colonoscopy bowel preparation using oral sodium phosphate solution.

  S Y Nam, I J Choi, K W Park, K H Ryu, B C Kim, D K Sohn, B H Nam, C G Kim
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  ABSTRACT: Oral sodium phosphate (NaP) solution is widely used for colonoscopy bowel preparation and it may cause aphthous ulcers in the colon. Our aim was to evaluate whether oral NaP solution is associated with gastric mucosal lesions. A total of 20 070 individuals underwent esophagogastroduodenoscopy (EGD) with colonoscopy, and 4271 individuals underwent EGD without colonoscopy, for cancer screening. Oral NaP solutions were used for bowel preparation prior to colonoscopy. Hemorrhagic gastropathy was graded using a five-point scale for erosive mucosal injury. The effect of NaP bowel preparation on hemorrhagic gastropathy was estimated using multiple logistic regression analysis with odds ratios (ORs) and 95 % confidence intervals (CIs). The incidence of hemorrhagic gastropathy was 1.6 % (70/4271) in the EGD only group and 4.0 % (809/20 070) in the EGD with colonoscopy group ( P < 0.001, unadjusted OR 2.55, 95 %CI 1.99 - 3.27). The ORs for mild (grade 1 - 2), moderate (grade 3), and severe (grade 4) hemorrhagic gastropathy according to NaP use were 1.92 (95 %CI 1.45 - 2.54), 4.72 (95 %CI 2.65 - 8.47), and 5.99 (95 %CI 1.46 - 24.63), respectively. After adjustment for confounding factors, NaP solution was a significant risk factor for acute hemorrhagic gastropathy in the multivariate analysis (OR 1.92, 95 %CI 1.34-2.74). In addition, male sex, a body mass index (kg/m (2)) of less than 20, concurrent use of antihypertensive or nonsteroidal anti-inflammatory drugs, and duodenal ulcers were independently associated with the development of hemorrhagic gastropathy. HELICOBACTER PYLORI infection and atrophic gastritis were negatively associated with hemorrhagic gastropathy. Oral NaP bowel preparation for colonoscopy was associated with hemorrhagic gastropathy.
  Endoscopy 02/2010; 42(2):109-13. · 5.21 Impact Factor
• Article: Obesity and weight gain as risk factors for erosive oesophagitis in men.

  S Y Nam, I J Choi, B H Nam, K W Park, C G Kim
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  ABSTRACT: Although obesity and weight gain increase the risk for symptoms of gastro-oesophageal reflux disease, their association with erosive oesophagitis is still unclear in the male population. To evaluate, in men, the association of body mass index (BMI) and weight gain with endoscopically proven erosive oesophagitis. A total of 8571 Korean men in a comprehensive screening cohort were enrolled. Effects of BMI and abdominal obesity on erosive oesophagitis were estimated with odds ratios (ORs) and 95% confidence intervals (CIs) using logistic regression analysis. We also evaluated the association between erosive oesophagitis and BMI change after 1-3 years. The prevalence of erosive oesophagitis was 6.4% (552/8571). In univariate analysis, the ORs for erosive oesophagitis increased as BMI or waist circumference increased (P for trend <0.001, both). In multivariate analysis, OR for erosive oesophagitis increased as BMI increased (P for trend = 0.002), while the significance of waist circumference was attenuated (P for trend = 0.13). Increase in BMI (>or=1 kg/m2) was associated with persistence of erosive oesophagitis (OR = 2.83, 95% CI: 1.01-7.92, P = 0.04) and new development of the disease (OR = 2.13, 95% CI: 1.38-3.28, P = 0.001) compared with BMI change less than 1 kg/m2. Elevated BMI and weight gain have a significant association with erosive oesophagitis.
  Alimentary Pharmacology & Therapeutics 02/2009; 29(9):1042-52. · 3.77 Impact Factor