Evangelia Tantalaki

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Publications (2)5.43 Total impact

  • Article: The effect of oral micronized progesterone on hormonal and metabolic parameters in anovulatory patients with polycystic ovary syndrome.
    Sarantis Livadas, Georgios Boutzios, Fragiskos Economou, Krystallenia Alexandraki, Xenofon Xyrafis, Maria Christou, Aristea Zerva, Athanasios Karachalios, Evangelia Tantalaki, Evanthia Diamanti-Kandarakis
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    ABSTRACT: To investigate the effects of oral natural micronized P on hormonal and metabolic parameters in patients with polycystic ovary syndrome (PCOS) and to answer the clinical question whether induction of withdrawal bleeding is a necessity for the comparison of hormonal and metabolic data in subjects with PCOS. Prospective clinical study. Academic medical center. Twenty-eight reproductive-aged women with PCOS. Blood sampling was collected at baseline, after 7 days of oral natural micronized P (200 mg) administration, and after withdrawal bleeding. At these three stages hormonal parameters and homeostasis assessment model (HOMA-IR) index were assessed in all patients. Oral natural micronized P administration did not alter significantly insulin sensitivity index and androgen levels; however, LH was decreased when postbleeding values were compared to baseline. Nevertheless, after oral natural micronized P administration, P and 17alpha-hydroxyprogesterone (17-OHP) concentrations were increased, and HOMA-IR was decreased, whereas androgens levels were not altered, in comparison with baseline. The induction of withdrawal bleeding, with this regimen, does not appear to be a necessity for the assessment of hormonal and metabolic profile in anovulatory women with PCOS.
    Fertility and sterility 05/2009; 94(1):242-6. · 3.97 Impact Factor
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    Article: Hyperreninemia characterizing women with polycystic ovary syndrome improves after metformin therapy.
    Evanthia Diamanti-Kandarakis, Frangiskos N Economou, Sarantis Livadas, Evangelia Tantalaki, Christina Piperi, Athanasios G Papavassiliou, Dimitrios Panidis
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    ABSTRACT: Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation, hyperandrogenemia and insulin resistance. Hyperreninemia is observed in insulin resistance and hyperandrogenemic states. To investigate the levels of total plasma renin and their possible relationship with insulin resistance and hyperandrogenemia and to explore the effect of metformin on these parameters in PCOS women. 48 PCOS women who were age- and body mass index (BMI)-matched with 21 healthy women were studied. Total renin, aldosterone levels, glucose and insulin levels were measured at basal state and during an oral glucose tolerance test in all subjects. A subgroup of women with PCOS was evaluated 6 months after metformin administration. Total renin levels were significantly higher in PCOS women compared to controls. PCOS women compared to controls displayed higher areas under the curve for glucose, insulin and total renin (AUCREN). Mean AUCREN was correlated significantly with insulin resistance indices and positively with free testosterone levels. Total renin, aldosterone, androgen levels and insulin sensitivity indices were significantly improved after 6 months on metformin treatment. PCOS women demonstrated an insulin resistance and hyperandogenemia-related increase in serum total renin levels. Metformin treatment was shown to significantly reduce total renin levels.
    Kidney and Blood Pressure Research 03/2009; 32(1):24-31. · 1.46 Impact Factor
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