Publications (5)8.41 Total impact
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Article: Interaction between Maternal Passive Smoking during Pregnancy and CYP1A1 and GSTs Polymorphisms on Spontaneous Preterm Delivery.
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ABSTRACT: OBJECTIVE: The present study aimed to examine the association between maternal passive smoking during pregnancy and the risk of spontaneous PTD and to explore the potential interaction of the single or joint gene polymorphism of CYP1A1 and GSTs with maternal passive smoking on the risk of spontaneous PTD. METHOD: We investigated whether the association between maternal passive smoking and PTD can be modified by 2 metabolic genes, i.e. cytochrome P4501A1 (CYP1A1) and glutathione S-transferases (GSTs), in a case-control study with 198 spontaneous preterm and 524 term deliveries in Shenzhen and Foshan, China. We used logistic regression to test gene-passive smoking interaction, adjusting for maternal socio-demographics and prepregnancy body mass index. RESULTS: Overall, maternal passive smoking during pregnancy was associated with higher risk of PTD (adjusted odds ratio = 2.20 [95% confidence interval: 1.56-3.12]). This association was modified by CYP1A1 and GSTs together, but not by any single genotype. For cross-categories of CYP1A1 Msp I and GSTs, maternal passive smoking was associated with higher risk of PTD among those women with CYP1A1 "TC/CC"+ GSTs "null", but not among women with other genotypes; and this interaction was significant (OR = 2.66 [95% CI: 1.19-5.97]; P-value: 0.017). For cross-categories of CYP1A1 BsrD I and GSTs, maternal passive smoking was associated with higher risk of PTD only among those women with CYP1A1"AG/GG"+ GSTs "null", but not among women with other genotypes; and this interaction was significant (OR = 3.00 [95% CI: 1.17-7.74]; P-value: 0.023). CONCLUSIONS: Our findings suggest that the combined genotypes of CYP1A1 and GSTs can help to identify vulnerable pregnant women who are subject to high risk of spontaneous PTD due to passive smoking.PLoS ONE 01/2012; 7(11):e49155. · 4.09 Impact Factor -
Conference Proceeding: A similarity network approach for analyzing the marine microbial diversity
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ABSTRACT: The microbes in the world's oceans are most abundant organisms on earth, playing an important role in the maintenance the balance of marine ecology. However, little knowledge of ecological interdependencies is known due to the limitation of current method for large-scale data and narrow surveys done for marine microbes while microbe exhibited significant inter-lineage associations naturally. Here we present a similarity network-based method to represent and analyze potential interactions among the marine microbes based on the 16S rRNA sequences. A set of parameters such as network degrees, short path, clustering coefficient and so on, are computed to characterize the similarity network topology. A few core sub networks (or network motifs) were found which show that microbe in the marine environment has a cluster propensity and evolutionary relatedness, meanwhile, the variable of network motif also indicated that the microbial diversity has a regional difference. These results show the network-based methods are effective for advance understanding the complexity and function of the marine microbial community after experiment technical.Systems Biology (ISB), 2011 IEEE International Conference on; 10/2011 -
Article: Associations of CYP2A6 genotype with smoking behaviors in southern China.
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ABSTRACT: To investigate the association of CYP2A6 genetic polymorphisms with smoking-related phenotypes in Chinese smokers. Case-only genetic association study. Southern China. A total of 1328 Han Chinese smokers who participated in a community-based chronic disease screening project in Guangzhou and Zhuhai from 2006 to 2007. All participants answered a structured questionnaire about socio-demographic status and smoking behaviors and informative alleles were genotyped for the cytochrome P450 2A6 (CYP2A6) gene (CYP2A6*4,*5,*7,*9 and *10). The frequencies of CYP2A6*4, *5, *7, *9 and *10 alleles were 8.5, 1.2, 6.3, 13.5 and 2.4%, which corresponded to 48.9, 15.4, 24.2 and 11.5% of participants being classified as normal, intermediate, slow and poor metabolizers, respectively. Multivariate analyses in male smokers demonstrated that compared with normal metabolizers, poor metabolizers reported smoking fewer cigarettes per day [adjusted odds ratio (OR) = 0.49; 95% confidence interval (CI): 0.32-0.76], started smoking regularly later in life (adjusted OR = 1.55; 95% CI: 1.06-2.26) and, among former smokers, reported smoking for a shorter duration prior to quitting (adjusted OR = 0.33; 95% CI: 0.12-0.94). However, poor metabolizers were less likely to quit smoking and remain abstinent than normal metabolizers (adjusted OR = 0.54; 95% CI: 0.34-0.86). Conclusions: Reduced metabolism function of cytochrome P450 2A6 in smokers appears to be associated with fewer cigarettes smoked, later initiation of smoking regularly, shorter smoking duration and lower likelihood of smoking cessation.Addiction 12/2010; 106(5):985-94. · 4.31 Impact Factor -
Article: [A meta-analysis on the association between maternal passive smoking during pregnancy and small-for-gestational-age infants].
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ABSTRACT: To study the association between maternal passive smoking during pregnancy and the small-for-gestational-age (SGA) infants and to analyze independent factors on duration, in different areas. Totally, 8 retrospective studies published in PubMed (no year limited), OVID-MEDLINE (no year limited), CNKI (from 1911 to 2008), VIP (from 1989 to 2008), and CBM (no year limited), on maternal passive smoking during pregnancy and SGA were analyzed synthetically by Meta-analysis. The unadjusted pooled OR value on the association between maternal passive smoking during pregnancy and SGA was 1.45 (95% CI: 1.05-2.01). Data showed that the adjusted pooled OR value was 1.76 (95% CI: 1.15-2.69). Maternal passive smoking in early pregnancy was a risk factor for SGA (OR = 1.85, 95% CI: 1.25-2.72), and so was the exposure in mid or late pregnancy(OR = 2.12, 95% CI: 1.43-3.13). No statistically significant relationship between SGA and passive smoking at home or at workplace was found. Avoiding passive smoking in pregnancy for mothers could reduce the possibility of delivering SGA infants. Other than at home or at workplace, problem of passive smoking in other places should also be brought up.Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 02/2009; 30(1):68-72. -
Article: Study of CNx films on 316L stainless steel for orthodontic application
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ABSTRACT: In order to improve the friction property and corrosion resistance of 316L stainless steel (316LSS) in orthodontic application, carbon nitride (CNx) films were synthesized by using IBAD technique at a set of assisted N ion beam currents. X-ray photoelectron spectroscopy and Raman spectroscopy were used to characterize the bonding state and the microstructure of the CNx films. Results of tribological tests indicated that the 316LSS coated by CNx films exhibited lower friction coefficients than the uncoated one both in air and in artificial saliva. The electrochemical tests in artificial saliva confirmed that the corrosion resistance of 316LSS was evidently improved after coated with CNx films.Diamond and Related Materials.
