Yi Huang

Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Hua-yang, Sichuan, China

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Publications (51)76.91 Total impact

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    ABSTRACT: The beneficial effect of a porous structure on the biological functions of calcium phosphate bulk ceramic or scaffold has been well documented. Nevertheless, the effect of a porous structure on the in vivo performance of hydroxyapatite (HA) coatings has been rarely reported, partly due to the difficulty in synthesizing porous HA coatings suitable for commercial applications. In this study, we have carried out a systematic in vivo study of porous HA-coated Ti implants (with and without surface modification) prepared by the liquid precursor plasma spraying process, in terms of its osteoconductivity and osteoinductivity. The results suggest the clear advantage of the porous structure over the dense structure, despite the pore structure (about 48% porosity and less than 100 μm average pore size) being far from the ideal pore structure reported for bulk ceramic. The porous HA-coated implant significantly promotes early bone ingrowth at the pre-generated defective region, and early fixation at the bone–implant interface, especially at early implantation time (one month), showing about 120% and 40% increases respectively over those of the dense HA-coated implants prepared by the conventional atmospheric plasma spraying process. Moreover, the porous structure can be readily used to incorporate collagen/rh-BMP2, which demonstrates clear ectopic bone formation. Overall, the results suggest the augmentation of bone ingrowth is significant for HA coatings with a porous structure, which is critical for the early fixation and long-term stability of medical implants.
    Biomedical Materials 11/2014; 9(6):065007. DOI:10.1088/1748-6041/9/6/065007 · 2.92 Impact Factor
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    ABSTRACT: To examine the personality traits of Chinese adolescents with non-suicidal self-injury (NSSI) and suicide attempt (SA). A cross-sectional survey on 2 131 middle school students in Dujiangyan city was conducted using the Eysenck Personality Questionnaire (EPQ, Children's Version) and Self- harm Behaviors Questionnaire (SHQ). The sample was stratified selected, comprising 1 085 boys and 1 046 girls with an average age of (13. 92±1. 63) years. The study population was categorized into four groups according to their non-suicidal and suicidal behaviors measured by the SHQ: those without self-harm (NoSH), those with non suicidal self-injury exclusively (NSSI only), those only with suicide attempts (SA only) and those with both NSSI and SA (NSSI+ SA). A MANCOVA model was constructed, with age and gender treated as covariates. We compared the four subscales of EPQ (Neuroticism, Psychoticism, Extraversion, Lie) between the four groups of study populations. NSSI was reported by 23. 2% (n 494) of respondents, and 3. 2% (n= 68) reported having at least one SA. A total of 1 617 (75.88%) respondents were identified as NoSH; 446 (20. 93%) as NSSI only; 20 (0.94%) as SA only, and 48 (2.25%) as NSSI+SA. Psychoticism, extraversion, and neuroticism were risk factors for self-harm behaviors. The NSSI+ SA group showed significantly higher psychoticism scores than respondents only with NSSI (P<0. 008 3,d=0. 59). The NSSI+SA group had a higher extraversion score than the NSSI group (P>0. 008 3,d=0. 38). Personality traits are closely associated with self-harm behaviors. Prevention of self harm behaviors should consider personality characteristics of middle school students.
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    ABSTRACT: This study aimed to explore further the mechanisms of tongue squamous cell carcinoma (TSCC) cell recurrence, metastasis, and diffusion, as well as to establish the experimental basis for the molecular biology research on TSSC. We intend to complete our objective through differential proteomics and preliminary analysis protein expression of exosomes derived from TSCC and normal mucosa cells.
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    ABSTRACT: Autistic traits including social reciprocal deficits, communication deficits and stereotyped behaviors, are manifested not only in patients with autism spectrum disorders (ASD) and their families, but also in general population. In recent years, there has much research related to autistic traits. This ariticle summarizes research advance of autistic traits in ASD relations and general population.
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    ABSTRACT: To explore the effects of stress imposed on adenoid cystic carcinoma (ACC), therefore to clarify the molecular basis and mechanism of ACC's malignant phenotype under the elevated tumor interstitial fluid pressure.
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    ABSTRACT: Glycogen synthase kinase 3 beta (GSK3β) is centrally involved in diverse cellular processes, including proliferation and apoptosis. This study aimed to investigate the influence of GSK3β expression on the prognosis of human non-small cell lung cancer (NSCLC) and the effects of GSK3β inhibition in NSCLC cell lines. Immunohistochemical and western blot assays were used to evaluate the GSK3β expression level in human NSCLC tissues. Lentiviral RNA interference was performed to inhibit the expression of GSK3β in the A549, H292, H1299 and SK-MES-1 cell lines. Cell survival, apoptosis and motility were evaluated in vivo and in vitro. The levels of GSK3β were greater in NSCLC tissues (n = 211) than in control tissues (n = 194) (P<0.001). The 5-year follow-up analysis showed that positive GSK3β expression was indicative of poor prognosis (P = 0.006). Furthermore, knockdown of GSK3β in NSCLC cell lines suppressed cell proliferation, arrested tumor cells in G0/G1 phase, induced apoptosis and reduced cell motility. A xenograft model showed that the deregulation of GSK3β attenuated tumorigenesis, as confirmed by reduced cell proliferation based on Ki-67 and significantly increased apoptotic cell death. The inhibition of GSK3β had inconsistent effects on the expression of β-catenin, depending on the cell type examined. Aberrant expression of GSK3β serves as an independent marker of poor prognosis for NSCLC. The inhibition of GSK3β suppressed tumorigenesis by attenuating cell proliferation, increasing apoptosis and restraining cell motility. These results identify GSK3β as a tumor promoter and a potential therapeutic target in NSCLC.
    PLoS ONE 03/2014; 9(3):e91231. DOI:10.1371/journal.pone.0091231 · 3.53 Impact Factor
    This article is viewable in ResearchGate's enriched format
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    ABSTRACT: Through a simulation of interstitial fluid pressure (IFP), we developed an in vitro model to explore the change law of biological characteristics of adenoid cystic carcinoma (ACC) under different IFP. A pressure cooker was refitted into a controllable pressure device. Cultured ACC-2 cells were subdivided into different groups, namely, negative control (untreated ACC-2) and experimental group (stressed for 3, 6, 12, 24 h under pressure of 7.551, 7.649, 7.747 kPa). CCK-8 and immunofluorescence of Ki67 were used to reflect proliferation ability. Transwell chamber assay was performed to observe the invasion ability of cells. The proliferation ability was positively correlated with treatment time, and the peak value was obtained after the cells were subjected to 7.649 kPa of stress for 24 h. The invasion ability of ACC-2 cells was upregulated under stress. We successfully developed an in vitro model of IFP and found that high IFP can stimulate cell proliferation ability and upregulate invasion ability.
    Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology 02/2014; 32(1):9-12.
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    ABSTRACT: Family functioning influences the course and long-term outcome for patients with depression. It is important to understand the family functioning of depressed patients from the viewpoint both of patients and their family members. The objective of this study was to explore the association between family functioning and depression in a sample of Chinese families, using the Family Assessment Device (FAD) and the Family Adaptability and Cohesion Evaluation Scales II (FACES II). This study was conducted in a sample of 61 depressed patients and their family members and 61 nonclinical controls in mainland China. It compared the perception of depressed patients and their family members and evaluated agreement between family members. Results indicate that in mainland China, functioning among families with a depressed family member is poorer than that of control families. Depressed patients reported less satisfaction than did their family members. There were significant differences on 4 of the 7 FAD scales among depressed patients and their family members, whereas no discrepancies were found on the FACES II. For the FAD, low agreement between patients and family members was found on all scales except behavioral control. Moderate agreement appeared on all dimensions of FACES II except for ideal cohesion and dissatisfaction with cohesion for the families of depressed patients. Depression is associated with impaired family functioning in families in mainland China. When applying the FAD and FACES II to samples of Chinese families, clinicians should be aware that the FAD may be more sensitive to detecting problems in some areas than the FACES II.
    Annals of Clinical Psychiatry 02/2014; 26(1):47-56. · 2.53 Impact Factor
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    ABSTRACT: The eruption of developed teeth from the buccal mucosa is a rare phenomenon in the head and neck region. Such phenomena are possibly choristomas, tumorlike masses of histologically normal tissue occurring in an abnormal position. However, the accurate classification of this abnormality remains debatable. This report describes a case of a congenital, maldevelopmental, and noncystic lesion in a 4-year-old girl without other anomalies. To the authors' knowledge, this is the first case of multiple supernumerary teeth forming in the buccal and zygomatic regions.
    Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons 08/2013; 71(11). DOI:10.1016/j.joms.2013.07.006 · 1.58 Impact Factor
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    ABSTRACT: BACKGROUND: The pro-apoptotic Bcl-2 protein BAD initiated apoptosis in human cells and has been identified as a prognostic marker in non-small cell lung cancer (NSCLC). In this study, we aimed to explore the functions of BAD in NSCLC. METHODS: Overexpression of BAD was performed by transfecting different NSCLC cell lines with wild-type BAD. Cell proliferation, cell cycle, apoptosis, and invasion were characterized in vitro. Tumorigenicity was analyzed in vivo. Western blot was performed to determine the effects of BAD overexpression on the Bcl-2 family proteins and apoptosis-related proteins. RESULTS: Overexpression of BAD significantly inhibited cell proliferation in H1299, H292, and SPC-A1 but not in SK-MES-1 and H460 cell lines in vitro. BAD overexpression also reduced the tumorigenicity of H1299/SPC-A1 cell in vivo. However, no appreciable effects on cell cycle distribution and invasion were observed in all these cell lines. BAD overexpression also induced apoptosis in all cell types, in which process expression of mitochondrial cytochrom c (cyto-c) and caspase 3 were increased, whereas Bcl-xl, Bcl-2, Bax and caspase 8 expressions did not changed. These findings indicated that a mitochondrial pathway, in which process cyto-c was released from mitochondrial to activate caspase 3, was involved in BAD overexpression-mediated apoptosis. CONCLUSIONS: Our data suggested that increased expression of BAD enhance apoptosis and has negative influence on cell proliferation and tumor growth in NSCLC. Bad is a new potential target for tumor interventions.
    Cancer Cell International 06/2013; 13(1):53. DOI:10.1186/1475-2867-13-53 · 1.99 Impact Factor
    This article is viewable in ResearchGate's enriched format
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    ABSTRACT: BACKGROUND: Epidermal growth factor receptor (EGFR) is involved in the development of many human malignant tumors and plays an important role in tumor growth and metastasis. Antagonists of EGFR can suppress the growth of several malignancies; however, their therapeutic effect in adenoid cystic carcinoma (ACC) is controversial. RESULTS: The increased proliferation of two ACC cell lines induced by EGF-treatment was reversed by nimotuzumab. Regardless of EGF stimulation, nimotuzumab-treated ACC cells were arrested in G1 phase and showed decreased expression of Ki67. In addition, EGF activated the MAPK-dependent pathway and up-regulated the expression of matrix metalloproteinase-9 and Snail, enhancing the invasive potential of an ACC cell line (ACC-M). The effects of EGF were down-regulated by nimotuzumab treatment. CONCLUSIONS: These results suggest that nimotuzumab can inhibit the growth and invasion of ACC cells induced by EGF, probably through inactivation of ERK phosphorylation. Thus, nimotuzumab should be considered as a promising novel agent for the treatment of ACC.
    BMC Cell Biology 03/2013; 14(1):13. DOI:10.1186/1471-2121-14-13 · 2.84 Impact Factor
    This article is viewable in ResearchGate's enriched format
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    ABSTRACT: Purpose: Self-harm behaviors are predominant health risks among adolescents. This study aimed to elucidate the lifetime prevalence and differences in social psychological factors between non-suicidal self-injury (NSSI) and suicide attempt (SA) among Chinese adolescents. Method: Data were collected from 2131 middle school students with a mean age of 13.92 (SD1.63) years (49.1% girls). Participants were asked to self-report NSSI and SA over their lifetime. Post hoc tests pairwise comparisons and multinomial logistic regression analyses were conducted to investigate differences and similarities between subjects with NSSI and attempted suicide. Results: The prevalence of lifetime NSSI and SA endorsed by the participants were 23.2% and 3.2%, respectively, and the co-occurrence of these two behaviors (NSSI + SA) was reported to 2.3%. Boys were comparable with girls in the prevalence rate of NSSI, but not in the rate of SA. It revealed that single-child was not the risk factor for self-harm behavior in Mainland China, but lower higher family cohesion and adaptability. Factors that distinguished the NSSI + SA group from the NSSI only group were female gender, lower grade, impulsivity, health risk behaviors and family cohesion. Being female gender, single-parent family, depressive symptoms and impulsivity were factors differentiating attempted suicide from NSSI. Conclusions: Our findings suggest that Chinese adolescents engaging both in NSSI and SA had severe suicidal attempts and were different from those who engaged in NSSI alone.
    Asian Journal of Psychiatry 01/2013; DOI:10.1016/j.ajp.2013.11.015
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    ABSTRACT: Apolipoprotein E (apo E) polymorphism has been reported to influence some lipid profile abnormalities in some ethnic groups. This study was conducted mainly to examine the possible association of apo E polymorphism with overweight/obesity in a South West Chinese population. Four hundred and fifty-four Han Chinese (282 overweight/obese and 172 normal weight control subjects) in Chengdu area were studied using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. The genotype and allele frequencies of apo E polymorphism in cases of overweight/obesity showed no significant statistical difference compared to those of controls. In the control group, both apo E4 and E3 allele carriers had the higher serum LDL-C and lower triglycerides (TGs) and apo E concentrations than those with apo E2 carriers, while apo E2 allele carriers had higher serum apo C-II levels than apo E3 carriers (P < 0.05). In overweight/obese group, genotype-related low density Lipoprotein-Cholesterol (LDL-C) variations were also evident, with the changes being in a same direction as the effect in the controls, and apo B100 levels were decreased and apo E increased in apo E2 allele carriers when compared with respective apo E4 and apo E4/apo E3 allele carriers (all P < 0.05). Polymorphism of the apo E gene is associated with altered plasma LDL-C and TG, as well as apo B, apo C-II, and apo E concentrations. The effects on TG, apo B, and apo C-II levels are BMI dependent in Chinese population of Chengdu area.
    Journal of Clinical Laboratory Analysis 05/2012; 26(3):200-5. DOI:10.1002/jcla.21494 · 1.14 Impact Factor
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    ABSTRACT: ApoL-I is a newly found component of high-density lipoprotein, and has a potential role in lipid metabolism. This study was mainly to examine the possible association of the ApoL-I gene polymorphism with obesity and plasma lipid levels in the Chinese population. Three hundred nineteen Han Chinese (109 obese and 210 nonobese control subjects) in Chengdu area were studied using polymerase chain reaction-restriction fragment length polymorphism analysis. The Lys and Glu allele frequencies of the apoL-I gene at the Lys166Glu site in obese and nonobese control groups were 0.830, 0.170 and 0.814, 0.186, respectively. The Ile and Met allele frequencies of the gene at Ile244Met site in the obese and the control groups were 0.844, 0.156 and 0.831, 0.169, respectively. The 166Glu and 244Met allele frequencies of the two polymorphisms in obese subjects were not different from those in the controls, respectively (p>0.05). In the nonobese group, subjects with genotype Lys/Lys at the Lys166Glu site or Ile/Ile at the Ile244Met site had a higher serum mean concentration of triglyceride (TG) as compared with those of corresponding Glu or Met allele carriers (p<0.05). In addition, serum apoC-III and apoE levels were affected by genotypes of Lys166Glu and Ile224Met polymorphisms, respectively, in the control group (all p<0.05). The current study, for the first time, provides evidence that Lys166Glu and Ile244Met polymorphisms in apoL-I gene are associated with TG, apoC-III, and apoE levels in nonobese Chinese. However, these polymorphisms are not associated with obesity in the population.
    Genetic Testing and Molecular Biomarkers 01/2012; 16(6):514-8. DOI:10.1089/gtmb.2011.0250 · 1.44 Impact Factor
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    ABSTRACT: To understand the prevalence and risk factors of non-suicidal self-injury in middle school students. 1312 middle school students of Pengzhou and Santai were selected to fill in a Risky Behavior Questionnaire for Adoluscents (RBQ-A), Family Environment Scale (FES), Center for Epidemiological Survey, Depression Scale (CES-D), Adolescent Self-Rating Life Events Check List (ASLEC), Social Support Scale for Adolescents (SSSA) and self-administered questionnaire. In all the research subjects, 1288 were qualified for the study in April 2011 before the risk factors for non-suicidal self-injury were identified by logistic regression. In 1288 middle school students, 22.67% had a history of non-suicidal self-injury, with 22.70% in boys and 22.64% in girls. 63.36% of students had injured themselves through variously ways, more seen in boys (26.88%) than in girls (11.36%) who cut or burnt themselves. The scores of ASLEC and CES-D in non-suicidal self-injury group appeared higher than that in the control group and the score of SSSA was found higher in the control group. The main risk factors for non-suicidal self-injuries were family conflict, depressive emotion, negative life events and receiving less social support. The prevalence of non-suicidal self-injury among middle school students in Pengzhou was high, whicn called for more attention.
    Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 01/2012; 33(1):46-9.
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    ABSTRACT: CXC chemokine receptor 4 (CXCR4) is involved in many human malignant tumors and plays an important role in tumor growth and metastasis. To explore the effects of CXCR4 expression on the malignant cells of oral squamous cell carcinoma (OSCC), Tca8113 and SCC-9 cell lines, as well as their xenograft models, of nude mice were used to detect cancer cell proliferation alteration. This study also examined the corresponding molecular mechanism after CXCR4 knockdown using a recombinant lentiviral vector expressing small interference RNA (siRNA) for CXCR4. RNA interference-mediated knockdown of CXCR4 in highly aggressive (Tca8113 and SCC-9) tumor cells significantly inhibited the proliferation of the two cell lines in vitro and in vivo. The expression levels of >1,500 genes involved in cell cycle, apoptosis, and multiple signaling pathways were also altered. These results provide new evidence of CXCR4 as a promising tumor gene therapeutic target.
    Molecular Therapy 11/2011; 20(2):398-407. DOI:10.1038/mt.2011.257 · 6.43 Impact Factor
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    ABSTRACT: We describe a case of arrested spontaneous mandibular resorption for which there was no effective treatment. A 32-year-old male patient presented to our department with mandibular resorption so severe that the residual mandibular body bone resembled chopsticks. A provisional diagnosis of Gorham-Stout Syndrome (GSS) was made. VEGF levels found in plasma and tissue fluid was believed to be a possible marker for the condition. Although there was no histological evidence for the diagnosis, a combination of the history, physical changes, and pathological findings in the soft tissues, we believe the diagnosis of GSS using VEGF as a marker was reasonable. There are over 200 reports of GSS in the literature. Most of the research has focused on the pathologic changes in the bone, but the condition of the related soft tissues has usually been ignored. We believe that this report is one of the first cases in which the mandibular resorption has been arrested for some time, during which the soft tissue is still in a pathological condition.
    Journal of cranio-maxillo-facial surgery: official publication of the European Association for Cranio-Maxillo-Facial Surgery 09/2011; 40(6):e174-7. DOI:10.1016/j.jcms.2011.08.011 · 1.25 Impact Factor
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    ABSTRACT: Proapoptotic BH-3-only protein Bad (Bcl-Xl/Bcl-2-associated death promoter homolog, Bad) initiates apoptosis in human cells, and contributes to tumorigenesis and chemotherapy resistant in malignancies. This study explored association between the Bad expression level and prognosis in patients with non-small cell lung cancer (NSCLC). In our study, a cohort of 88 resected primary NSCLC cases were collected and analyzed. Bad expression level was determined via immunohistochemical staining assay. The prognostic significances of Bad expression were evaluated with univariate and multivariate survival analysis. The results showed that compared with normal lung tissues, Bad expression level significantly decreased in NSCLC (P < 0.05). Bad expression was associated with adjuvant therapy status. Loss of Bad independently predicted poor prognosis in whole NSCLC cohort and early stage subjects (T1 + T2 and N0 + N1) (all P < 0.05). Overall survival time was also drastically shortened for Bad negative phenotype in NSCLC patients with smoking history, especially lung squamous cell carcinoma (all P < 0.05). In conclusion, this study provided clinical evidence that loss of Bad is an independent and powerful predictor of adverse prognosis in NSCLC. Bad protein could be a new biomarker for selecting individual therapy strategies and predicting therapeutic response in subjects with NSCLC.
    Medical Oncology 09/2011; 29(3):1648-55. DOI:10.1007/s12032-011-0060-4 · 2.06 Impact Factor
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    ABSTRACT: The mammalian Janus kinase (JAK) family plays a critical role in cytokine/growth factor signalling pathways and is associated with human cancers. In this study, we explored the role of JAK1 in the non-small cell lung cancer (NSCLC) cell line A549 and its molecular crosstalk with the phosphatidyl inositol-3-kinase (PI3K)/mammalian target of the rapamycin (mTOR) pathway. One hundred and two NSCLC and 50 normal lung specimens were collected after surgical resection. JAK1 expression and phosphorylation were determined via immunohistochemical staining (IHC) assay. A stable knockdown of JAK1 was performed in A549 cells by RNA interference. Stable cell proliferation, cell cycle, apoptosis, and invasion were characterised in vitro. Tumourigenicity was analysed in vivo. The NSCLC xenograft protein expression of PI3K/mTOR pathway molecules was determined by Western blot assay. JAK1 expression was higher in NSCLC tissues than in normal lung tissues (P < 0.01). JAK1 knockdown in A549 cells significantly inhibited cell proliferation and invasion while promoting cell arrest at G0/G1 phase (all P < 0.05). The xenograft model showed that JAK1 suppression inhibited tumour growth compared with normal control (P < 0.05). Moreover, JAK1 knockdown inhibited mTOR or P70 ribosomal protein S6 kinase (P70S6K) phosphorylation, but increased glycogen synthase kinase-3α (GSK-3α) and B-cell lymphoma-extra large (Bcl-xl) phosphorylation. Total protein expression and Akt1/2 phosphorylated status remained unchanged. Our study suggests that JAK1 expression and phosphorylation is abnormal in NSCLC tissues. The knockdown of JAK1 significantly inhibits tumourigenicity of the A549 cell line and demonstrates that crosstalk between the JAK1 and PI3K/mTOR pathways is involved.
    Journal of Cancer Research and Clinical Oncology 08/2011; 137(11):1629-40. DOI:10.1007/s00432-011-1037-6 · 2.91 Impact Factor
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    ABSTRACT: This study was to analyze the mental health status of the children and adolescents from the areas struck by Wenchuan earthquake and to understand the factors that may have impact on their mental health after exposing to the earthquake. Subjects of this survey were students (8 - 16 years old) from Chendu, Dujiangyan, Beichuan and Wenchuan districts which were the most severely affected areas in the earthquake. We analyzed the subjects' mental health conditions after Wenchuan earthquake by using a general questionnaire that was composed of the Children's Revised Impact of Event Scale (CRIES-13) and Depression Self-rating Scale for Children (DSRSC). Students are investigated 7341 case, 7387 case, 7395 case after 3, 6, 24 months. The data were analyzed with logistic regression model. The CRIES-13 scores were (27.51 ± 12.26), (23.54 ± 12.79) and (21.35 ± 12.59) (F = 28.842, P ≤ 0.05) and the DSRSC scores were (11.79 ± 5.73), (10.94 ± 5.50) and (10.75 ± 5.27) (F = 17.084, P ≤ 0.05) 3, 6 and 24 months after the earthquake, respectively. The risk factors associated with depression 3, 6, 24 months after the earthquake were gender (female) (OR values were 2.14, 2.72, 2.31; 95%CI values were 1.01 - 3.03, 1.10 - 5.01, 1.02 - 4.58), age (less than 12 years old) (OR values were 1.97, 2.22, 1.93; 95%CI values were 1.43 - 3.17, 1.02 - 3.54, 1.32 - 3.27), having family member injury and death (OR values were 2.19, 2.45, 2.35; 95%CI values were 1.04-2.89, 1.16-2.08, 1.02 - 2.79), desperation (OR values were 2.24, 2.09, 2.16; 95%CI values were 1.00 - 2.54, 1.70 - 2.58, 1.00 - 4.56). The risk factors associated with PTSD 3, 6, 24 months after the earthquake were gender (OR values were 2.16, 2.94, 1.96; 95%CI values were 1.36 - 2.53, 1.36 - 2.53, 1.06 - 3.92), age (less than 12 years old) (OR values were 3.51, 2.62, 1.92; 95%CI values were 1.22 - 5.40, 1.14 - 4.93, 1.08 - 3.35), having teachers and schoolmates injury and death (OR values were 2.32, 2.48, 2.36; 95%CI values were 1.17 - 2.48, 1.30 - 2.72, 1.02 - 2.85), having family member injury and death (OR values were 2.73, 2.21, 1.85;95%CI values were 1.67 - 3.61, 1.04 - 3.15, 1.05 - 2.38), witnessing injury (OR values were 2.17, 2.36, 2.34; 95%CI values were 1.15 - 3.65, 1.17 - 2.67, 1.02 - 3.67), witnessing death (OR values were 1.98, 2.39, 1.71;95%CI values were 1.10 - 2.56, 1.14 - 3.70, 1.57 - 3.88), desperation (OR values were 2.02, 1.94, 2.02; 95%CI values were 1.67 - 2.35, 1.66 - 2.27, 1.82 - 2.26). The symptoms of PTSD and depression of young survivors from the earthquake-struck areas had gradually alleviated 3, 6, 24 months after the earthquake. Age (less than 12 years old), gender (female), having family member injury and death, witnessing injury and death, and desperation were the main risk factors that affected the children and adolescents mental health.
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 06/2011; 45(6):531-6.

Publication Stats

244 Citations
76.91 Total Impact Points

Institutions

  • 2011–2014
    • Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
      Hua-yang, Sichuan, China
  • 2002–2014
    • Sichuan University
      • • National Engineering Research Center for Biomaterials
      • • State Key Laboratory of Biotherapy
      • • Mental Health Center
      Hua-yang, Sichuan, China
  • 2005
    • University of British Columbia - Vancouver
      • Brain Research Centre
      Vancouver, British Columbia, Canada