Yi Huang

West China Hospital of Stomatology, Hua-yang, Sichuan, China

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Publications (58)91.47 Total impact

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    ABSTRACT: The beneficial effect of a porous structure on the biological functions of calcium phosphate bulk ceramic or scaffold has been well documented. Nevertheless, the effect of a porous structure on the in vivo performance of hydroxyapatite (HA) coatings has been rarely reported, partly due to the difficulty in synthesizing porous HA coatings suitable for commercial applications. In this study, we have carried out a systematic in vivo study of porous HA-coated Ti implants (with and without surface modification) prepared by the liquid precursor plasma spraying process, in terms of its osteoconductivity and osteoinductivity. The results suggest the clear advantage of the porous structure over the dense structure, despite the pore structure (about 48% porosity and less than 100 μm average pore size) being far from the ideal pore structure reported for bulk ceramic. The porous HA-coated implant significantly promotes early bone ingrowth at the pre-generated defective region, and early fixation at the bone–implant interface, especially at early implantation time (one month), showing about 120% and 40% increases respectively over those of the dense HA-coated implants prepared by the conventional atmospheric plasma spraying process. Moreover, the porous structure can be readily used to incorporate collagen/rh-BMP2, which demonstrates clear ectopic bone formation. Overall, the results suggest the augmentation of bone ingrowth is significant for HA coatings with a porous structure, which is critical for the early fixation and long-term stability of medical implants.
    Biomedical Materials 11/2014; 9(6):065007. DOI:10.1088/1748-6041/9/6/065007 · 2.92 Impact Factor
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    ABSTRACT: To examine the personality traits of Chinese adolescents with non-suicidal self-injury (NSSI) and suicide attempt (SA). A cross-sectional survey on 2 131 middle school students in Dujiangyan city was conducted using the Eysenck Personality Questionnaire (EPQ, Children's Version) and Self- harm Behaviors Questionnaire (SHQ). The sample was stratified selected, comprising 1 085 boys and 1 046 girls with an average age of (13. 92±1. 63) years. The study population was categorized into four groups according to their non-suicidal and suicidal behaviors measured by the SHQ: those without self-harm (NoSH), those with non suicidal self-injury exclusively (NSSI only), those only with suicide attempts (SA only) and those with both NSSI and SA (NSSI+ SA). A MANCOVA model was constructed, with age and gender treated as covariates. We compared the four subscales of EPQ (Neuroticism, Psychoticism, Extraversion, Lie) between the four groups of study populations. NSSI was reported by 23. 2% (n 494) of respondents, and 3. 2% (n= 68) reported having at least one SA. A total of 1 617 (75.88%) respondents were identified as NoSH; 446 (20. 93%) as NSSI only; 20 (0.94%) as SA only, and 48 (2.25%) as NSSI+SA. Psychoticism, extraversion, and neuroticism were risk factors for self-harm behaviors. The NSSI+ SA group showed significantly higher psychoticism scores than respondents only with NSSI (P<0. 008 3,d=0. 59). The NSSI+SA group had a higher extraversion score than the NSSI group (P>0. 008 3,d=0. 38). Personality traits are closely associated with self-harm behaviors. Prevention of self harm behaviors should consider personality characteristics of middle school students.
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    ABSTRACT: This study aimed to explore further the mechanisms of tongue squamous cell carcinoma (TSCC) cell recurrence, metastasis, and diffusion, as well as to establish the experimental basis for the molecular biology research on TSSC. We intend to complete our objective through differential proteomics and preliminary analysis protein expression of exosomes derived from TSCC and normal mucosa cells.
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    ABSTRACT: Autistic traits including social reciprocal deficits, communication deficits and stereotyped behaviors, are manifested not only in patients with autism spectrum disorders (ASD) and their families, but also in general population. In recent years, there has much research related to autistic traits. This ariticle summarizes research advance of autistic traits in ASD relations and general population.
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    ABSTRACT: To explore the effects of stress imposed on adenoid cystic carcinoma (ACC), therefore to clarify the molecular basis and mechanism of ACC's malignant phenotype under the elevated tumor interstitial fluid pressure.
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    ABSTRACT: Glycogen synthase kinase 3 beta (GSK3β) is centrally involved in diverse cellular processes, including proliferation and apoptosis. This study aimed to investigate the influence of GSK3β expression on the prognosis of human non-small cell lung cancer (NSCLC) and the effects of GSK3β inhibition in NSCLC cell lines. Immunohistochemical and western blot assays were used to evaluate the GSK3β expression level in human NSCLC tissues. Lentiviral RNA interference was performed to inhibit the expression of GSK3β in the A549, H292, H1299 and SK-MES-1 cell lines. Cell survival, apoptosis and motility were evaluated in vivo and in vitro. The levels of GSK3β were greater in NSCLC tissues (n = 211) than in control tissues (n = 194) (P<0.001). The 5-year follow-up analysis showed that positive GSK3β expression was indicative of poor prognosis (P = 0.006). Furthermore, knockdown of GSK3β in NSCLC cell lines suppressed cell proliferation, arrested tumor cells in G0/G1 phase, induced apoptosis and reduced cell motility. A xenograft model showed that the deregulation of GSK3β attenuated tumorigenesis, as confirmed by reduced cell proliferation based on Ki-67 and significantly increased apoptotic cell death. The inhibition of GSK3β had inconsistent effects on the expression of β-catenin, depending on the cell type examined. Aberrant expression of GSK3β serves as an independent marker of poor prognosis for NSCLC. The inhibition of GSK3β suppressed tumorigenesis by attenuating cell proliferation, increasing apoptosis and restraining cell motility. These results identify GSK3β as a tumor promoter and a potential therapeutic target in NSCLC.
    PLoS ONE 03/2014; 9(3):e91231. DOI:10.1371/journal.pone.0091231 · 3.53 Impact Factor
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    ABSTRACT: Through a simulation of interstitial fluid pressure (IFP), we developed an in vitro model to explore the change law of biological characteristics of adenoid cystic carcinoma (ACC) under different IFP. A pressure cooker was refitted into a controllable pressure device. Cultured ACC-2 cells were subdivided into different groups, namely, negative control (untreated ACC-2) and experimental group (stressed for 3, 6, 12, 24 h under pressure of 7.551, 7.649, 7.747 kPa). CCK-8 and immunofluorescence of Ki67 were used to reflect proliferation ability. Transwell chamber assay was performed to observe the invasion ability of cells. The proliferation ability was positively correlated with treatment time, and the peak value was obtained after the cells were subjected to 7.649 kPa of stress for 24 h. The invasion ability of ACC-2 cells was upregulated under stress. We successfully developed an in vitro model of IFP and found that high IFP can stimulate cell proliferation ability and upregulate invasion ability.
    Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology 02/2014; 32(1):9-12.
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    ABSTRACT: Family functioning influences the course and long-term outcome for patients with depression. It is important to understand the family functioning of depressed patients from the viewpoint both of patients and their family members. The objective of this study was to explore the association between family functioning and depression in a sample of Chinese families, using the Family Assessment Device (FAD) and the Family Adaptability and Cohesion Evaluation Scales II (FACES II). This study was conducted in a sample of 61 depressed patients and their family members and 61 nonclinical controls in mainland China. It compared the perception of depressed patients and their family members and evaluated agreement between family members. Results indicate that in mainland China, functioning among families with a depressed family member is poorer than that of control families. Depressed patients reported less satisfaction than did their family members. There were significant differences on 4 of the 7 FAD scales among depressed patients and their family members, whereas no discrepancies were found on the FACES II. For the FAD, low agreement between patients and family members was found on all scales except behavioral control. Moderate agreement appeared on all dimensions of FACES II except for ideal cohesion and dissatisfaction with cohesion for the families of depressed patients. Depression is associated with impaired family functioning in families in mainland China. When applying the FAD and FACES II to samples of Chinese families, clinicians should be aware that the FAD may be more sensitive to detecting problems in some areas than the FACES II.
    Annals of Clinical Psychiatry 02/2014; 26(1):47-56. · 2.53 Impact Factor
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    ABSTRACT: The objective of the study was to assess the efficacy and safety of mepivacaine compared with lidocaine used in local anaesthesia in dentistry. Medline, Cochrane Central Register of Controlled Trials, EMBASE, Chinese BioMedical Literature Database, China National Knowledge Infrastructure and WHO International Clinical Trials Registry Platform were searched electronically. Relevant journals and references of studies included were hand-searched for randomised controlled trials comparing mepivacaine with lidocaine in terms of efficacy and safety. Twenty-eight studies were included, of which 15 had low risk of bias and 13 had moderate risk of bias. In comparison with 2% lidocaine with 1:100,000 adrenaline, 3% mepivacaine showed a lower success rate (P = 0.05), a shorter onset time of pulpal anaesthesia (P = 0.0005), inferior pain control during injection phase and superior inhibition of heart rate increase (P < 0.0001). In contrast, 2% mepivacaine with 1:100,000 adrenaline gave a higher success rate (P < 0.00001), a similar onset time of pulpal anaesthesia (P = 0.34) and superior pain control during injection phase (P < 0.0001); 2% mepivacaine with 1:20,000 levonordefrin had the same success rate (P = 0.69) and similar onset time of pulpal anaesthesia (P = 0.90). In addition, 3% mepivacaine had shorter onset time (P = 0.004), same level of success rate (P = 0.28) and similar pain control during injection and postinjection compared with 2% lidocaine with 1:50,000 adrenaline. Given the efficacy and safety of the two solutions, 2% mepivacaine with vasoconstrictors is better than 2% lidocaine with vasoconstrictors in dental treatment. Meanwhile, 3% plain mepivacaine is better for patients with cardiac diseases.
    International Dental Journal 01/2014; 64(2). DOI:10.1111/idj.12087 · 1.20 Impact Factor
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    ABSTRACT: The objective of this study was to assess the efficacy and safety of bupivacaine compared with lidocaine in local anaesthesia in dental treatment. Medline, Cochrane Central Register of Controlled Trials, EMBASE, Chinese BioMedical Literature Database, China National Knowledge Infrastructure, and the World Health Organisation (WHO) International Clinical Trials Registry Platform were searched electronically. Relevant journals and references of studies included were hand-searched for randomised controlled trials comparing bupivacaine with lidocaine in terms of efficacy and safety. Sixteen studies were included, of which nine had low, six had moderate and one had high risk of bias. In comparison with 2% lidocaine plus 1:100,000 adrenaline, 0.5% bupivacaine plus 1:200,000 adrenaline showed a higher success rate in inflamed pulp (P = 0.03) but a lower success rate in vital pulp (P < 0.00001), a lower percentage of patients using postoperative analgesics (P < 0.00001), a longer onset times of pulpal anaesthesia and a longer duration of pulpal anaesthesia (P < 0.00001). In comparison with 2% lidocaine plus 1:80,000 adrenaline, 0.75% bupivacaine plus 1:200,000 adrenaline had same level of success rate (P = 0.29), and was better in postoperative pain control (P = 0.001) while 0.75% levobupivacaine had same level of postoperative pain control (P = 0.16); 0.5% levobupivacaine had higher success rate (P = 0.04) and was better in postoperative pain control (P = 0.001) than 2% lidocaine. There was no statistically significance in adverse events between two groups. Given the efficacy and safety, the bupivacaine group is better than the lidocaine group in dental operations that take a relatively long time, especially in endodontic treatments or where there is a need for postoperative pain management.
    International Dental Journal 10/2013; DOI:10.1111/idj.12060 · 1.20 Impact Factor
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    ABSTRACT: The eruption of developed teeth from the buccal mucosa is a rare phenomenon in the head and neck region. Such phenomena are possibly choristomas, tumorlike masses of histologically normal tissue occurring in an abnormal position. However, the accurate classification of this abnormality remains debatable. This report describes a case of a congenital, maldevelopmental, and noncystic lesion in a 4-year-old girl without other anomalies. To the authors' knowledge, this is the first case of multiple supernumerary teeth forming in the buccal and zygomatic regions.
    Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons 08/2013; 71(11). DOI:10.1016/j.joms.2013.07.006 · 1.28 Impact Factor
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    ABSTRACT: A novel analytical toxicology method has been developed for the analysis of drugs of abuse in human urine by using a high resolution and high mass accuracy hybrid linear ion trap-Orbitrap mass spectrometer (LTQ-Orbitrap-MS). This method allows for the detection of different drugs of abuse, including amphetamines, cocaine, opiate alkaloids, cannabinoids, hallucinogens and their metabolites. After solid-phase extraction with Oasis HLB cartridges, spiked urine samples were analysed by HPLC/LTQ-Orbitrap-MS using an electrospray interface in positive ionisation mode, with resolving power of 30,000 full width at half maximum (FWHM). Gradient elution off of a Hypersil Gold PFP column (50mm×2.1mm) allowed to resolve 65 target compounds and 3 internal standards in a total chromatographic run time of 20min. Validation of this method consisted of confirmation of identity, selectivity, linearity, limit of detection (LOD), lowest limits of quantification (LLOQ), accuracy, precision, extraction recovery and matrix effect. The regression coefficients (r(2)) for the calibration curves (LLOQ - 100ng/mL) in the study were ≥0.99. The LODs for 65 validated compounds were better than 5ng/ml except for 4 compounds. The relative standard deviation (RSD), which was used to estimate repeatability at three concentrations, was always less than 15%. The recovery of extraction and matrix effects were above 50 and 70%, respectively. Mass accuracy was always better than 2ppm, corresponding to a maximum mass error of 0.8 millimass units (mmu). The accurate masses of characteristic fragments were obtained by collisional experiments for a more reliable identification of the analytes. Automated data analysis and reporting were performed using ToxID software with an exact mass database. This procedure was then successfully applied to analyse drugs of abuse in a real urine sample from subject who was assumed to be drug addict.
    Journal of Chromatography A 06/2013; 1302. DOI:10.1016/j.chroma.2013.06.028 · 4.26 Impact Factor
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    ABSTRACT: BACKGROUND: The pro-apoptotic Bcl-2 protein BAD initiated apoptosis in human cells and has been identified as a prognostic marker in non-small cell lung cancer (NSCLC). In this study, we aimed to explore the functions of BAD in NSCLC. METHODS: Overexpression of BAD was performed by transfecting different NSCLC cell lines with wild-type BAD. Cell proliferation, cell cycle, apoptosis, and invasion were characterized in vitro. Tumorigenicity was analyzed in vivo. Western blot was performed to determine the effects of BAD overexpression on the Bcl-2 family proteins and apoptosis-related proteins. RESULTS: Overexpression of BAD significantly inhibited cell proliferation in H1299, H292, and SPC-A1 but not in SK-MES-1 and H460 cell lines in vitro. BAD overexpression also reduced the tumorigenicity of H1299/SPC-A1 cell in vivo. However, no appreciable effects on cell cycle distribution and invasion were observed in all these cell lines. BAD overexpression also induced apoptosis in all cell types, in which process expression of mitochondrial cytochrom c (cyto-c) and caspase 3 were increased, whereas Bcl-xl, Bcl-2, Bax and caspase 8 expressions did not changed. These findings indicated that a mitochondrial pathway, in which process cyto-c was released from mitochondrial to activate caspase 3, was involved in BAD overexpression-mediated apoptosis. CONCLUSIONS: Our data suggested that increased expression of BAD enhance apoptosis and has negative influence on cell proliferation and tumor growth in NSCLC. Bad is a new potential target for tumor interventions.
    Cancer Cell International 06/2013; 13(1):53. DOI:10.1186/1475-2867-13-53 · 1.99 Impact Factor
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    ABSTRACT: BACKGROUND: Epidermal growth factor receptor (EGFR) is involved in the development of many human malignant tumors and plays an important role in tumor growth and metastasis. Antagonists of EGFR can suppress the growth of several malignancies; however, their therapeutic effect in adenoid cystic carcinoma (ACC) is controversial. RESULTS: The increased proliferation of two ACC cell lines induced by EGF-treatment was reversed by nimotuzumab. Regardless of EGF stimulation, nimotuzumab-treated ACC cells were arrested in G1 phase and showed decreased expression of Ki67. In addition, EGF activated the MAPK-dependent pathway and up-regulated the expression of matrix metalloproteinase-9 and Snail, enhancing the invasive potential of an ACC cell line (ACC-M). The effects of EGF were down-regulated by nimotuzumab treatment. CONCLUSIONS: These results suggest that nimotuzumab can inhibit the growth and invasion of ACC cells induced by EGF, probably through inactivation of ERK phosphorylation. Thus, nimotuzumab should be considered as a promising novel agent for the treatment of ACC.
    BMC Cell Biology 03/2013; 14(1):13. DOI:10.1186/1471-2121-14-13 · 2.84 Impact Factor
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    ABSTRACT: Heroin is a highly addictive drug, and heroin abuse is considered to be a serious criminal act. The major metabolite of heroin, morphine, can usually be detected as evidence of heroin abuse. However, it is difficult to determine heroin use when morphine and codeine are both detected, because codeine use will also result in the presence of morphine in urine. Therefore, it is important to distinguish heroin abuse from codeine administration. In this study, urine samples from 21 volunteers with various ingestion patterns of a compound codeine phosphate oral solution were used as negative controls, and urine samples from 89 alleged heroin users were used as positive controls. Urine from single and multiple doses of codeine administration were collected at different time points for a systematic comparison. After protein precipitation, the urine samples were analyzed for the presence of free morphine, free codeine and their metabolites by ultra-performance liquid chromatography-tandem mass spectrometry. The method of percentiles, with median and standard interquartile ranges, was used to describe and analyze the data based on the normality of the distribution. The ratios of concentration of morphine and morphine to codeine were found to be the possible criteria to distinguish heroin users from codeine users in Chinese people.
    Journal of analytical toxicology 01/2013; 37(3). DOI:10.1093/jat/bks093 · 2.63 Impact Factor
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    ABSTRACT: Objectives To evaluate the changes in oral-health-related quality of life (OHRQoL) in patients with temporomandibular joint osteoarthritis (TMJ-OA) who underwent five weekly hyaluronic acid injections together with oral glucosamine hydrochloride for three months. Materials and methods This prospective observational study included 211 consecutive patients who completed the Chinese version of the 14-item Oral Health Impact Profile (OHIP-C14) before treatment (T0), and at first month (T1), third month (T2), and sixth month (T3) after the first injection. Results Significant changes in the summary scores on OHIP-C14 were observed during follow-up (P < 0.001). The scores were significantly reduced at T1, T2, and T3 compared with T0 (P < 0.001), and were significantly reduced from T0 to T1 (P < 0.001) and T1 to T2 (P < 0.001), but not from T2 to T3 (P = 0.369). Compared with the norms, the scores were significantly higher at T0 (P < 0.001), not significantly different at T1 (P = 0.482), and significantly lower at T2 (P = 0.013) and T3 (P = 0.003). The changes in the scores differed significantly among age groups (P = 0.012) but not between sexes (P = 0.293). Conclusions TMJ-OA has a negative effect on patient OHRQoL. OHRQoL scores were improved to normal levels in both the short and long terms after therapy. OHRQoL improvement was the greatest in the youngest group, but did not differ between the sexes.
    Journal of Cranio-Maxillofacial Surgery 01/2013; 42(6). DOI:10.1016/j.jcms.2013.12.003 · 2.60 Impact Factor
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    ABSTRACT: Purpose: Self-harm behaviors are predominant health risks among adolescents. This study aimed to elucidate the lifetime prevalence and differences in social psychological factors between non-suicidal self-injury (NSSI) and suicide attempt (SA) among Chinese adolescents. Method: Data were collected from 2131 middle school students with a mean age of 13.92 (SD1.63) years (49.1% girls). Participants were asked to self-report NSSI and SA over their lifetime. Post hoc tests pairwise comparisons and multinomial logistic regression analyses were conducted to investigate differences and similarities between subjects with NSSI and attempted suicide. Results: The prevalence of lifetime NSSI and SA endorsed by the participants were 23.2% and 3.2%, respectively, and the co-occurrence of these two behaviors (NSSI + SA) was reported to 2.3%. Boys were comparable with girls in the prevalence rate of NSSI, but not in the rate of SA. It revealed that single-child was not the risk factor for self-harm behavior in Mainland China, but lower higher family cohesion and adaptability. Factors that distinguished the NSSI + SA group from the NSSI only group were female gender, lower grade, impulsivity, health risk behaviors and family cohesion. Being female gender, single-parent family, depressive symptoms and impulsivity were factors differentiating attempted suicide from NSSI. Conclusions: Our findings suggest that Chinese adolescents engaging both in NSSI and SA had severe suicidal attempts and were different from those who engaged in NSSI alone.
    Asian Journal of Psychiatry 01/2013; 8. DOI:10.1016/j.ajp.2013.11.015
  • Psychology 01/2013; 04(06):535-540. DOI:10.4236/psych.2013.46076
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    ABSTRACT: Based on our previous report on N-alkylpyridinium isotope quaternization (NAPIQ) for the analysis of alcoholic and α,β-unsaturated ketone compounds, we have further applied NAPIQ method in the screening of hair lipids in drug abusers. Relative isotopic quantification was used for comparison of fatty alcohols between normal and drug abuse group. The NAPIQ strategy was proven to be a high-throughput method in the metabolic comparison studies of different group samples. The attached N-cationic pyridinium significantly improved the detection sensitivity for these fatty alcohols in matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometric (MALDI-FTMS) analysis. The experimental results showed that the levels of fatty alcohols in the hair of heroin abuse group decreased significantly compared with the normal groups, which may be the results of the inducing of peroxidation enzyme. NAPIQ was proven to be an effective and alternative method in the research of fatty alcoholic metabolism for drug abuse monitoring.
    Chinese Journal of Chemistry 10/2012; 30(10). DOI:10.1002/cjoc.201200547 · 1.04 Impact Factor
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    ABSTRACT: Apolipoprotein E (apo E) polymorphism has been reported to influence some lipid profile abnormalities in some ethnic groups. This study was conducted mainly to examine the possible association of apo E polymorphism with overweight/obesity in a South West Chinese population. Four hundred and fifty-four Han Chinese (282 overweight/obese and 172 normal weight control subjects) in Chengdu area were studied using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. The genotype and allele frequencies of apo E polymorphism in cases of overweight/obesity showed no significant statistical difference compared to those of controls. In the control group, both apo E4 and E3 allele carriers had the higher serum LDL-C and lower triglycerides (TGs) and apo E concentrations than those with apo E2 carriers, while apo E2 allele carriers had higher serum apo C-II levels than apo E3 carriers (P < 0.05). In overweight/obese group, genotype-related low density Lipoprotein-Cholesterol (LDL-C) variations were also evident, with the changes being in a same direction as the effect in the controls, and apo B100 levels were decreased and apo E increased in apo E2 allele carriers when compared with respective apo E4 and apo E4/apo E3 allele carriers (all P < 0.05). Polymorphism of the apo E gene is associated with altered plasma LDL-C and TG, as well as apo B, apo C-II, and apo E concentrations. The effects on TG, apo B, and apo C-II levels are BMI dependent in Chinese population of Chengdu area.
    Journal of Clinical Laboratory Analysis 05/2012; 26(3):200-5. DOI:10.1002/jcla.21494 · 1.14 Impact Factor

Publication Stats

273 Citations
91.47 Total Impact Points

Institutions

  • 2014
    • West China Hospital of Stomatology
      Hua-yang, Sichuan, China
  • 2011–2014
    • Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
      Hua-yang, Sichuan, China
  • 2002–2014
    • Sichuan University
      • • National Engineering Research Center for Biomaterials
      • • State Key Laboratory of Biotherapy
      • • Mental Health Center
      Hua-yang, Sichuan, China
  • 2012
    • Institute of Forensic Science under the Ministry of Justice P.R. China
      Shanghai, Shanghai Shi, China
  • 2005
    • University of British Columbia - Vancouver
      • Brain Research Centre
      Vancouver, British Columbia, Canada