Gerasimos Tzortzatos

Karolinska University Hospital, Stockholm, Stockholm, Sweden

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Publications (3)11.58 Total impact

  • Gerasimos Tzortzatos, Angelos Sioutas, Mats O Beckman
    Thrombosis and Haemostasis 10/2009; 102(3):601-2. · 5.76 Impact Factor
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    ABSTRACT: The low molecular weight heparin, Dalteparin, shortens human labor time. The aim of this study was to investigate if the mechanism behind this effect involves myometrial contractility and cervical ripening and if the anticoagulative activity is necessary for its effect. Experimental in vitro study. Lund University and Karolinska Institute, Sweden. The effect of low molecular weight heparins with or without anticoagulative properties on myometrial contractility was measured in vitro on smooth muscle strips from biopsies obtained at elective cesarean sections. The effects on cervical ripening were assessed in cervical fibroblasts cultured from explants of cervical biopsies obtained at delivery. Mean force and number of contractions in uterine smooth muscle strips and interleukin-8 (IL-8) secretion in cervical fibroblasts. Myometrial smooth muscle strips pretreated with low molecular weight heparins showed increased contractile activity compared to untreated smooth muscle strips. Secretion of IL-8 from cultured cervical fibroblasts was significantly increased after treatment with low molecular weight heparin. Both these effects were independent of anticoagulative activity of the low molecular weight heparin. A possible underlying mechanism for the shortened labor time after low molecular weight heparin treatment is enhanced myometrial contractility and an increased IL-8 secretion in cervical fibroblast, mimicking the final cervical ripening in vivo. Our data support the notion that anticoagulant activity is not required to promote labor.
    Acta Obstetricia Et Gynecologica Scandinavica 09/2009; 88(9):984-9. · 1.85 Impact Factor
  • Gerasimos Tzortzatos, Angelos Sioutas, Kjell Schedvins
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    ABSTRACT: To report a case of successful IVF-pregnancy after treatment for ovarian growing teratoma syndrome. Case report. Gynecologic department at a university hospital. A 20-year-old woman, gravida 0 para 0, was diagnosed with malignant teratoma of the ovary. She was treated by unilateral salpingo-oophorectomy and chemotherapy. A couple of years later she was diagnosed with growing teratoma syndrome. Fertility-preserving surgery with unilateral salpingo-oophorectomy and chemotherapy. In vitro fertilization. Disease free, successful pregnancy. After treatment for ovarian immature teratoma and growing teratoma syndrome the patient was free of the disease. She underwent in vitro fertilization treatment with autologous embryo transfer and gave birth to a healthy child. Growing teratoma syndrome is an extremely rare metastatic complication of a malignant germ cell tumor after a combination treatment with surgery and adjuvant chemotherapy. This case shows that successful pregnancy outcome is possible after effective treatment for ovarian growing teratoma syndrome.
    Fertility and sterility 02/2009; 91(3):936.e1-3. · 3.97 Impact Factor