[show abstract][hide abstract] ABSTRACT: Both leukocytoclastic vasculitis and metastatic pulmonary calcification are conditions that rarely occur during the course of multiple myeloma. We present a multiple myeloma patient that had severe dyspnea due to metastatic pulmonary calcinosis, and ulceronecrotic skin lesions caused by leukocytoclastic vasculitis. After 3 courses of standarddose chemotherapy all skin and pulmonary lesions disappeared. Autologous peripheral stem cell transplantation was performed and during 1 year of follow-up the patient was in complete remission; after 1 year, laboratory test results indicated disease relapse. Although the patient was treated with bortezomib and dexamethasone, the disease progressed. Non-myeloablative allogeneic stem cell transplantation was performed, but despite of all treatment the patient died due to disease progression. Conflict of interest:None declared.
Turkish Journal of Haematology 12/2012; 29(4):397-400. · 0.49 Impact Factor
[show abstract][hide abstract] ABSTRACT: The authors report 2 children with generalized cutaneous sclerosis exposed to pesticides containing malathion and diniconazole. Treatment with immunosuppressives resulted in partial improvement in the cutaneous signs, particularly over the face, trunk, and proximal limbs. The considerable exposure to chemicals related with the initiation of symptoms and absence of organ involvement suggested a diagnosis of chemically induced scleroderma-like disorder. Although autoantibodies were negative, previously reported relevant associations of anti-kinetochore and anti-topoisomerase function of active ingredients-diniconazole and phosphorodithioate-and solvents of these pesticides are also discussed. Careful follow-up for systemic involvement is warranted, since these agents may have triggered systemic scleroderma in these patients. Elimination of chemical exposure of children is stressed.
Archives of Environmental and Occupational Health 01/2012; 67(1):43-7. · 1.19 Impact Factor
[show abstract][hide abstract] ABSTRACT: Extraskeletal Ewing's sarcoma is a mesenchymal malign soft tissue tumor which generally affects the lower extremities and paravertebral region and is very rarely seen in the head and neck area. Early diagnosis and chemotherapy and radiotherapy program combines with surgical excision would be the appropriate treatment modality. In this article we present a case of extraskeletal Ewing's sarcoma which arise from the buccal area as an unusual localization together with information from the literature. In the physical examination of a 23-year old male patient who admitted to our clinic with a complaint of painless mass on his cheek which had been increasingly growing for approximately three months, a painless semi-mobile mass of approximately 5 x 3 cm in size with regular borders and elastic consistency was found within buccal soft tissue in the left maxillary area. The mass was excised under general anesthesia. No local recurrences or findings of distant metastases were observed during the 11-month postoperative follow-up.
Kulak burun bogaz ihtisas dergisi: KBB = Journal of ear, nose, and throat 01/2011; 21(4):225-8.