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ABSTRACT: To evaluate the clinical effectiveness and safety of Sanchi Tong Shu capsule in the treatment of common aural vertigo.
A multi-center randomized controlled trial was designed to study 206 vertigo patients who were randomly allocated into one of the two groups. One group was treated with Sanchi Tong Shu capsule for 14 days, another group was treated with betahistine mesilate tablets for 14 days.
The clinical effectiveness rates of the two groups were 84.86% and 90.92% respectively according to FAS analysis and 84.76%, 90.92% respectively according to PPS analysis. No statistic significance difference was found between the two groups (P > 0.05). After 14 days treatment, total DHI and all the subsection (including body, emotion and fuction) scores of the two groups were all decreased compared with treatment before (P < 0.01). Compared the difference value of the total DHI and subsection scores before and after treatment, the two groups have no difference (P > 0.05). The adverse effective rate of the two groups were 3.29% and 7.84% respectively and there was no statistic difference between the two groups (P > 0.05).
Sanchi Tong Shu capsule is a safe and effective drug for the treatment of common aural vertigo.
Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology 04/2012; 26(7):295-9.
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Xiaoyuan Li, Juan Meng,
Xiaoming Qiao,
Yafeng Liu,
Feng Liu,
Nan Zhang,
Jie Zhang,
Gabriele Holtappels,
Ba Luo,
Peng Zhou,
Yongbo Zheng,
Ping Lin,
Shixi Liu,
Claus Bachert
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ABSTRACT: To date there is no information on the expression of mediators associated with tissue remodeling in Asian patients with chronic rhinitis with (CRSwNP) or without (CRSsNP) nasal polyps.
To study the expression of TGF-beta1, matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs), collagen, and regulatory T cells in Chinese patients with CRSwNP and CRSsNP.
Thirty-six male and female subjects (12 patients with CRSwNP, 12 patients with CRSsNP, and 12 control subjects), age 17 to 60 years, were recruited into the study. Samples were collected from polyp and sinusoidal mucosal, ethmoidal mucosal, or inferior turbinate in the respective groups and assessed for TGF- beta1, MMP-2, MMP-7, MMP-9, TIMP-1, TIMP-2, TIMP-3, and TIMP-4 by immunoassay; collagen by histochemistry; and forkhead box P3 (FOXP3) mRNA by real-time PCR.
Patients with CRSwNP showed significantly lower concentrations of TGF-beta1, TIMP-1, TIMP-4, FOXP3, and collagen compared with patients with CRSsNP. Although there were no significant differences between the concentrations of MMP-7 and MMP-9 in patients with CRSwNP and CRSsNP, these were significantly increased compared with control patients. MMP-2 and TIMP-2 concentrations were not significantly different in any patient group, whereas TIMP-3 was not detectable.
Chronic rhinosinusitis with nasal polyps is characterized by a relative lack of TGF-ss expression versus CRSsNP. This finding may be causal for decreased collagen, TIMP-1/4, and FOXP3 expression in CRSwNP versus CRSsNP. TGF-ss serves as a main switch for different remodeling patterns in sinus disease.
The Journal of allergy and clinical immunology 04/2010; 125(5):1061-8. · 9.17 Impact Factor
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ABSTRACT: The objective of this research was to create a Mandarin closed-set sentence recognition test based on the English pediatric speech intelligibility (PSI) test (Jerger & Jerger, 1984 ) for evaluation of speech perception in children as young as three years of age. Developmentally normal children (N = 93), 3-6 years of age, were administered the Mandarin PSI (MPSI) via a computer-controlled protocol. Perfect performance was observed for all children in quiet and at +10 and +5 dB signal-to-noise ratios (SNRs). Significant age and developmental trends were seen for the more difficult SNRs, 0 dB, -5 dB, and -10 dB, with 75% of 5-6 year olds reaching the most difficult SNR. Children who reached each of the more difficult SNRs, regardless of age, exhibited the same pattern of performance on all easier conditions, indicating that the final SNR achieved, rather than percent correct scores, may be a better descriptor of performance. The MPSI comprises part of a hierarchical assessment battery for pediatric speech perception for evaluation of intervention alternatives for Mandarin-speaking children with hearing impairment.
International journal of audiology 07/2009; 48(10):718-28. · 1.34 Impact Factor
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ABSTRACT: The normal trajectory of early prelingual auditory development from birth to 24 months of age was characterized in a sample of 120 normal-hearing infants and toddlers of Mandarin-Chinese-speaking parents. The Infant-Toddler Meaningful Auditory Integration Scale (IT-MAIS) was administered to parents as a structured interview during routine pediatric health examinations. Developmental trajectories for the overall IT-MAIS score, as well as for scores on the subscales that assess behavioral evidence of spontaneous detection of and responsiveness to sound and of spontaneous recognition and discrimination of sound, were represented by logarithmic regression functions. On average, these regression functions characterized over 80% of the age-related variance in each scale. The developmental trajectories revealed that by 16 months the average infant exhibited spontaneous detection of and responsiveness to sound at all times, while spontaneous recognition and discrimination of sound was seen at all times after 26 months. The trajectory for the overall IT-MAIS scale, which combines the two subscales, reached ceiling at 22 months. The overall trajectory for Chinese infants closely matches the trajectory for normal-hearing infants of Arabic- and Hebrew-speaking parents in Israel. The Chinese IT-MAIS also exhibits similar internal consistency and item reliability to the German, Polish, and British English IT-MAIS scales. These similarities seen across culturally and linguistically diverse populations suggest the early prelingual auditory development follows the same, or a very similar course, in all infants.
Audiology and Neurotology 02/2009; 14(4):214-22. · 2.46 Impact Factor
