Publications (4)8.9 Total impact
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Article: Transition metal mediated construction of pyrrole ring on 2,3-dihydroquinolin-4(1H)-one: synthesis and pharmacological evaluation of novel tricyclic heteroarenes.
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ABSTRACT: A facile two-step method for the construction of fused pyrrole ring leading to 5-substituted 2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-ones via C-C followed by intramolecular C-N bond forming reaction is described. In vitro pharmacological evaluation and molecular modelling studies of some of the compounds synthesized are presented.Organic & Biomolecular Chemistry 02/2011; 9(4):1004-7. · 3.70 Impact Factor -
Article: Pd/C-mediated synthesis of indoles in water.
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ABSTRACT: We describe the utility of a Pd/C-Cu mediated method in the synthesis of 2,5-disubstituted indoles in water via a coupling-cyclization strategy. Further application of this methodology has been demonstrated in the preparation of a target indole derivative via a 7-step process the key step being the Pd/C-mediated coupling reaction.Beilstein Journal of Organic Chemistry 01/2009; 5:46. · 2.52 Impact Factor -
Article: A highly effective synthesis of 2-alkynyl-7-azaindoles: Pd/C-mediated alkynylation of heteroaryl halides in water
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ABSTRACT: The reaction of 4-chloro-2-iodo-7-azaindole with terminal alkynes was investigated using 10% Pd/C–PPh3–CuI as a catalyst system in water. This study afforded a new, mild and selective process for the preparation of 2-alkynyl-4-chloro-7-azaindole in good yields via C–C bond forming reaction. The resulting chloro derivative can be functionalized further via another Pd-mediated C–C bond forming reaction with arylboronic acid.Graphical abstractTetrahedron. 65(25):4814-4819. -
Article: Pd/C–Cu in coupling-cyclization process: a general synthesis of 2-substituted 6-oxopyrrolo[3,2,1-ij]quinoline derivatives
Tetrahedron Letters 50(27):3867-3871. · 2.68 Impact Factor
