F Thouillot

Publications (5)15.23 Total impact

• Article: L’épidémie de grippe à virus A(H1N1) 2009 à la Réunion: données épidémiologiques

  P. Renault, F. Thouillot, C. Do, N. Baroux, A. Cadivel, E. Balleydier, E. Brottet, F. Kermarec, E. D’Ortenzio, L. Filleul
  [show abstract] [hide abstract]
  ABSTRACT: À la Réunion, le dispositif de surveillance de la grippe a permis de suivre la dynamique épidémiologique de l’épidémie liée à l’émergence du virus pandémique A(H1N1) 2009. Ce dispositif reposait principalement sur un réseau de médecins sentinelles, associé à une surveillance virologique, ainsi que sur un suivi des formes graves et des décès. Les données fournies étaient analysées et diffusées selon une fréquence hebdomadaire. Le premier cas importé a été confirmé le 5 juillet 2009 chez un voyageur en provenance d’Australie et les premiers cas autochtones étaient rapportés le 23 juillet. Le pic épidémique était atteint en cinq semaines et la durée de l’épisode épidémique a été de neuf semaines. Le virus pandémique a très rapidement supplanté les virus saisonniers qui avaient commencé à circuler et on estime à 12,85 % le taux d’attaque pour les cas symptomatiques d’infection par le virus A(H1N1) 2009. Le taux d’hospitalisation était de 32 pour 10 000 cas estimés et 24 personnes ont présenté une forme grave ayant nécessité un séjour en service de réanimation. Parmi les certificats de décès reçus par la direction régionale des affaires sanitaires et sociales, 14 mentionnaient la grippe, dont sept pour lesquels la présence du virus pandémique a été biologiquement confirmée. Ces décès sont survenus chez des sujets significativement plus jeunes qu’habituellement observé à la Réunion pour la grippe saisonnière. Dans l’ensemble, l’épidémie a été d’une intensité et d’une gravité analogues à celles de la grippe saisonnière sur l’île de la Réunion. In Reunion Island, a French subtropical island located in the southern hemisphere, the monitoring of the epidemiological dynamics of the epidemic linked to the emergence of pandemic virus A(H1N1) 2009 was achieved through the regular influenza surveillance system which has been reinforced on that occasion. It was mainly based on a network of sentinel physicians, combined with virologic monitoring, and on surveillance of severe cases and deaths. The data were analyzed and retroinformation was distributed according to a weekly frequency. The first imported case was confirmed on July 5, 2009 in a traveler arriving from Australia, whereas the first autochthonous cases were reported on July 23. The epidemic peak was reached in five weeks and the duration of the whole epidemic episode was 9 weeks. Pandemic virus has quickly supplanted seasonal viruses that had begun to circulate. The estimated attack rate for symptomatic cases of infection with virus influenza A(H1N1) 2009 was 12.85%. The hospitalization rate was 32 per 10,000 estimated cases, and 24 people had a serious form requiring care in ICU. Among death certificates received at the regional office for health and social affairs, 14 mentioned the influenza, including 7 in whom the pandemic virus has been laboratory confirmed. These deaths occurred in patients significantly younger than usually observed in Reunion Island during the seasonal influenza epidemics. Overall, the epidemic intensity and severity have been similar to those of seasonal influenza in Reunion Island. Mots clésGrippe–Virus pandémique A(H1N1) 2009–Surveillance virologique–Épidémiologie–Réseau de médecins sentinelles–Île de la Réunion KeywordsInfluenza–Pandemic A(H1N1) virus–Virologic monitoring epidemiology–Network of sentinel physicians–Reunion Island
  Bulletin de la Société de pathologie exotique 05/2012; 104(2):108-113.
• Article: [Epidemic of influenza A(H1N1) 2009 in Reunion Island: epidemiological data].

  P Renault, F Thouillot, C Do, N Baroux, A Cadivel, E Balleydier, E Brottet, F Kermarec, E D'Ortenzio, L Filleul
  [show abstract] [hide abstract]
  ABSTRACT: In Reunion Island, a French subtropical island located in the southern hemisphere, the monitoring of the epidemiological dynamics of the epidemic linked to the emergence of pandemic virus A(H1N1) 2009 was achieved through the regular influenza surveillance system which has been reinforced on that occasion. It was mainly based on a network of sentinel physicians, combined with virologic monitoring, and on surveillance of severe cases and deaths. The data were analyzed and retroinformation was distributed according to a weekly frequency. The first imported case was confirmed on July 5, 2009 in a traveler arriving from Australia, whereas the first autochthonous cases were reported on July 23. The epidemic peak was reached in five weeks and the duration of the whole epidemic episode was 9 weeks. Pandemic virus has quickly supplanted seasonal viruses that had begun to circulate. The estimated attack rate for symptomatic cases of infection with virus influenza A(H1N1) 2009 was 12.85%. The hospitalization rate was 32 per 10,000 estimated cases, and 24 people had a serious form requiring care in ICU. Among death certificates received at the regional office for health and social affairs, 14 mentioned the influenza, including 7 in whom the pandemic virus has been laboratory confirmed. These deaths occurred in patients significantly younger than usually observed in Reunion Island during the seasonal influenza epidemics. Overall, the epidemic intensity and severity have been similar to those of seasonal influenza in Reunion Island.
  Bulletin de la Société de pathologie exotique 12/2010; 104(2):108-13.
• Article: A review of the dynamics and severity of the pandemic A(H1N1) influenza virus on Réunion island, 2009.

  E D'Ortenzio, P Renault, M C Jaffar-Bandjee, B A Gaüzère, M Lagrange-Xélot, A Fouillet, P Poubeau, A Winer, A Bourde, F Staikowsky, P Morbidelli, E Rachou, F Thouillot, A Michault, L Filleul
  [show abstract] [hide abstract]
  ABSTRACT: On Reunion Island, in response to the threat of emergence of the pandemic influenza A(H1N1)2009 virus, we implemented enhanced influenza surveillance from May 2009 onwards in order to detect the introduction of pandemic H1N1 influenza and to monitor its spread and impact on public health. The first 2009 pandemic influenza A(H1N1) virus was identified in Réunion on July 5, 2009, in a traveller returning from Australia; seasonal influenza B virus activity had already been detected. By the end of July, a sustained community pandemic virus transmission had been established. Pandemic H1N1 influenza activity peaked during week 35 (24-30 August 2009), 4 weeks after the beginning of the epidemic. The epidemic ended on week 38 and had lasted 9 weeks. During these 9 weeks, an estimated 66 915 persons who consulted a physician could have been infected by the influenza A(H1N1)2009 virus, giving a cumulative attack rate for consultants of 8.26%. Taking into account the people who did not consult, the total number of infected persons reached 104 067, giving a cumulative attack rate for symptomatics of 12.85%. The crude fatality rate (CFR) for influenza A(H1N1)2009 and the CFR for acute respiratory infection was 0.7/10 000 cases. Our data show that influenza pandemic did not have a health impact on overall mortality on Réunion Island. These findings demonstrate the value of an integrated epidemiological, virological and hospital surveillance programme to monitor the scope of an epidemic, identify circulating strains and provide some guidance to public health control measures.
  Clinical Microbiology and Infection 04/2010; 16(4):309-16. · 4.54 Impact Factor
• Article: A review of the dynamics and severity of the pandemic A(H1N1) influenza virus on Réunion Island, 2009

  E. D’Ortenzio, P. Renault, M. C. Jaffar-Bandjee, B. A. Gaüzère, M. Lagrange-Xélot, A. Fouillet, P. Poubeau, A. Winer, A. Bourde, F. Staikowsky, P. Morbidelli, E. Rachou, F. Thouillot, A. Michault, L. Filleul
  [show abstract] [hide abstract]
  ABSTRACT: Clin Microbiol Infect 2010; 16: 309–316AbstractOn Reunion Island, in response to the threat of emergence of the pandemic influenza A(H1N1)2009 virus, we implemented enhanced influenza surveillance from May 2009 onwards in order to detect the introduction of pandemic H1N1 influenza and to monitor its spread and impact on public health. The first 2009 pandemic influenza A(H1N1) virus was identified in Réunion on July 5, 2009, in a traveller returning from Australia; seasonal influenza B virus activity had already been detected. By the end of July, a sustained community pandemic virus transmission had been established. Pandemic H1N1 influenza activity peaked during week 35 (24–30 August 2009), 4 weeks after the beginning of the epidemic. The epidemic ended on week 38 and had lasted 9 weeks. During these 9 weeks, an estimated 66 915 persons who consulted a physician could have been infected by the influenza A(H1N1)2009 virus, giving a cumulative attack rate for consultants of 8.26%. Taking into account the people who did not consult, the total number of infected persons reached 104 067, giving a cumulative attack rate for symptomatics of 12.85%. The crude fatality rate (CFR) for influenza A(H1N1)2009 and the CFR for acute respiratory infection was 0.7/10 000 cases. Our data show that influenza pandemic did not have a health impact on overall mortality on Réunion Island. These findings demonstrate the value of an integrated epidemiological, virological and hospital surveillance programme to monitor the scope of an epidemic, identify circulating strains and provide some guidance to public health control measures.
  Clinical Microbiology and Infection 03/2010; 16(4):309 - 316. · 4.54 Impact Factor
• Article: Preliminary analysis of the pandemic H1N1 influenza on Reunion Island (Indian Ocean): surveillance trends (July to mid-September 2009).

  F Thouillot, C Do, E Balleydier, E Rachou, F Staikowsky, P Morbidelli, Y Jacques-Antoine, A Bourde, M Lagrange-Xelot, P Poubeau, A Winer, Ba Gauzere, A Michault, Mc Jaffar-Bandjee, G Henrion, L Filleul, E D'Ortenzio
  [show abstract] [hide abstract]
  ABSTRACT: First infections with the 2009 pandemic H1N1 influenza virus were identified on Reunion Island in July 2009. By the end of July, sustained community transmission of the virus was established. Pandemic H1N1 influenza activity peaked during week 35 (24 to 30 August), five weeks after the beginning of the epidemic and has been declining since week 36. We report preliminary epidemiological characteristics of the pandemic on Reunion Island in 2009 until week 37 ending September 13.
  Euro surveillance: bulletin europeen sur les maladies transmissibles = European communicable disease bulletin 01/2009; 14(42). · 6.15 Impact Factor