D. Check

Cooper University Hospital, Camden, New Jersey, United States

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Publications (27)9.56 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: To determine the pregnancy rate following frozen embryo transfer using embryos derived from low dosage follicle stimulating hormone (FSH) stimulation protocols in women aged < 42 who did not have diminished egg reserve as evidenced by a day 3 serum FSH < or =12 mIU/ml. A retrospective review was performed evaluating pregnancy rates on frozen embryo transfers from women who usually had diminished egg reserve and thus used no more than 150 IU of FSH. The pregnancy rates were calculated on the first frozen embryo transfer of women failing to successfully conceive on the fresh embryo transfer. The clinical and live delivered pregnancy rates per transfer were 33.3% (14/42) and 23.8%. The implantation rate was 20.0%. Thirty-one percent of the transfers were in women aged 40-42. These data show that despite the fact that with minimal stimulation protocols, the remaining frozen embryos are of lesser quality because of de-selection, nevertheless, it is worth transferring these embryos.
    Clinical and experimental obstetrics & gynecology 01/2012; 39(2):139-40. · 0.38 Impact Factor
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    ABSTRACT: The hypothesis set forth is that the basis for a great many chronic debilitating conditions that involve almost all of the physiologic systems of the body may have as the underlying cause and a common link between them, i.e., hypofunction of the sympathetic nervous system. The hypothesis considers that one of the main functions of the sympathetic nervous system is to diminish cellular permeability. Thus sympathetic hypofunction may lead to absorption of chemicals and toxins into tissues that were supposed to be impervious leading to inflammation and other adverse consequences which then cause a wide variety of symptoms. These symptoms may include pain or diminished muscular function leading to various pain syndromes or conditions related to diminished muscular function. Furthermore since the sympathetic nervous system is involved in body homeostasis and temperature regulation, sympathetic nervous system hypofunction could lead to disorders in these areas, e.g., vasomotor symptoms and edema. This defect in sympathetic nervous system has a genetic predisposition but relatives, e.g., siblings or children may manifest in a different manner which suggests some influence of external factors causing one physiological system to be more prone than another to malfunction under conditions of sympathetic hypofunction. Evidence to support this hypothesis has been provided by a large number of published anecdotes demonstrating the quick and long lasting considerable improvement in symptoms following treatment with the sympathomimetic amine dextroamphetamine sulfate (with return of symptoms if treatment is temporarily ceased thus diminishing the likelihood of spontaneous remission) despite failure to respond to a plethora of other pharmacologic agents and other therapies over many years. The physiological systems with various chronic disorders that have responded included the gastrointestinal system, skin, genitourinary system, the nervous system, the musculoskeletal system, the temperature regulation system, peripheral vasculature system, and the endocrine system. Despite the multitude of very convincing anecdotal reports showing its efficacy (and to date no reports refuting this hypothesis), there has only been one controlled study which showed the benefit of dextroamphetamine sulfate on edema and weight gain in diet-refractory patients. The flaw to date for general acceptance of this hypothesis is that most positive studies are coming from one clinical center. Furthermore, more controlled studies are needed. There has been a recent interest amongst physiologists and recent studies have been published confirming a deficiency of sympathetic nerve fibers in some of these disorders which hopefully will encourage more research into other physiologic systems leading to corroboration of this hypothesis.
    Medical Hypotheses 08/2011; 77(5):717-25. · 1.18 Impact Factor
  • J H Check, R Cohen, D Check
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    ABSTRACT: To describe a novel therapy for women with intractable migraine headaches. Dextroamphetamine sulfate was prescribed to a 33-year-old woman with intractable migraine headaches resistant to standard therapy. Her only abnormality noted was unexplained weight gain. She failed a water load test. The headaches were 100% relieved by dextroamphetamine sulfate (Spansule - 45 mg/day). Intractable migraine headaches can be added to the list of various pain syndromes related to a disorder of the sympathetic nervous system resistant to standard therapy but showing dramatic improvement with treatment with sympathomimetic amines.
    Clinical and experimental obstetrics & gynecology 01/2011; 38(2):180-1. · 0.38 Impact Factor
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    ABSTRACT: To compare the efficacy of two treatments for sperm with low hypoosmotic swelling (HOS) test scores - intrauterine insemination (IUI) with sperm pretreated with the protein digestive enzyme chymotrypsin versus in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI). The choice of patient therapy was optional. The pregnancy rates following two IUI cycles vs one IVF cycle with ICSI were then compared. The data were further stratified and compared according to the severity of the HOS score defect. The more severe the HOS test defect the less likely for chymotrypsin therapy to work whereas the severity did not affect IVF with ICSI success. The use of IVF with ICSI was much more effective than IUI with chymotrypsin treatment. Though IVF with ICSI is much more effective, IUI is much less expensive. Couples should be presented with these data and be allowed to make their own choice considering risks and expense versus efficacy and speed of success.
    Clinical and experimental obstetrics & gynecology 01/2011; 38(1):24-5. · 0.38 Impact Factor
  • J H Check, R Cohen, D Check
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    ABSTRACT: To determine if the treatment of cold induced urticaria refractory to conventional antihistamine-type therapy would respond to treatment with sympathomimetic amines. Dextroamphetamine sulfate (15 mg) extended release capsules were prescribed to be taken daily in the morning. The cold-induced urticaria completely disappeared and antihistamine therapy was discontinued. Treatment of chronic refractory cold-induced urticaria effectively responds to treatment with sympathomimetic amines similar to other cases of chronic refractory urticaria that are not merely cold induced. Manifestation of idiopathic orthostatic edema, a condition predominantly of women, should always be considered in the differential diagnosis of baffling medical conditions.
    Clinical and experimental obstetrics & gynecology 01/2010; 37(3):235-6. · 0.38 Impact Factor
  • J H Check, R Cohen, D Check
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    ABSTRACT: To describe a novel highly effective therapy for vasomotor symptoms associated with diminished oocyte reserve. A 58-year-old estrogen deficient woman with severe vasomotor symptoms was treated with 20 mg per day of dextroamphetamine sulfate. A marked immediate improvement was noted. An acquired disorder of the sympathetic nervous system may be the etiologic factor for vasomotor symptoms in women with diminished egg reserve and treatment with sympathomimetic amines seems highly effective. This case will hopefully stimulate a larger series to determine its efficacy in a larger population.
    Clinical and experimental obstetrics & gynecology 01/2010; 37(3):229-30. · 0.38 Impact Factor
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    ABSTRACT: To determine if fertilization by intracytoplasmic sperm injection (ICSI) lowers pregnancy rates following frozen embryo transfer compared to conventional insemination similar to findings with fresh embryo transfer. Clinical and live delivered pregnancy and implantation rates were compared according to whether the eggs were fertilized by conventional oocyte insemination vs ICSI over a 10-year period in women whose husbands had normal semen parameters except for having normal strict morphology between 2-5%. The clinical and live delivered pregnancy rates were 40.9% and 31.9, respectively, with ICSI vs. 44.2% and 38.3% for women having conventional insemination. The difference in live delivered pregnancy rates approached statistical significance. Choosing ICSI for subnormal morphology may not only possibly lower the chance of successful pregnancy following fresh embryo transfer but possibly also following frozen embryo transfer.
    Clinical and experimental obstetrics & gynecology 01/2010; 37(1):17-8. · 0.38 Impact Factor
  • J H Check, D Check, R Cohen
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    ABSTRACT: To determine if sympathomimetic amine therapy, which has been effective in alleviating pain from various areas of the body in women previously refractory to conventional therapy, could help refractory migraine headaches. Two cases with severe migraines resistant to conventional therapy were evaluated to see the response to dextroamphetamine sulfate. Both women dramatically responded. Case 1 showed that the treatment benefit is long lasting and not merely transient as long as the woman remained on the sympathomimetic amine therapy. Case 2 showed that even premenstrual migraines can respond to this therapy. It is not clear if therapy would only benefit women with an abnormal water load test or not. To determine if this therapy could be effective in refractory headache cases, even in women who pass the water load test, one would have to try the dextroamphetamine under similar circumstances and see the response. Similarly it is not known if it could help males with refractory headaches.
    Clinical and experimental obstetrics & gynecology 01/2009; 36(3):189-91. · 0.38 Impact Factor
  • Fertility and Sterility - FERT STERIL. 01/2008; 89(4).
  • Fertility and Sterility - FERT STERIL. 01/2008; 89(4).
  • Fertility and Sterility - FERT STERIL. 01/2008; 90.
  • Fertility and Sterility - FERT STERIL. 01/2008; 90.
  • Fertility and Sterility - FERT STERIL. 01/2008; 89(4).
  • D. Check, J. H. Check, E. Dix
    Fertility and Sterility - FERT STERIL. 01/2008; 89(4).
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    ABSTRACT: To determine if a viable pregnancy is possible after aspiration of sperm from the testes of a man several hours after his death. Following cryopreservation of the aspirated sperm, in vitro fertilization (IVF)-embryo transfer (ET) with intracytoplasmic sperm injection (ICSI) was used. The sperm selected were either those with motility or plumper non-motile sperm. Fertilization of oocytes and ET occurred following all five IVF-ET cycles. A clinical pregnancy was achieved in cycle 1 with non-motile sperm and a viable pregnancy resulted from cycle 5 with ICSI performed with viable sperm. Viable pregnancies following IVF-ET and ICSI are possible even when using testicular sperm obtained posthumously.
    Clinical and experimental obstetrics & gynecology 02/2002; 29(2):95-6. · 0.38 Impact Factor
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    ABSTRACT: There is a need to develop a sperm cryopreservation technique that will allow good pregnancy rates following intrauterine insemination of thawed semen specimens that have been frozen prior to sperm-destructive procedures, such as surgery, chemotherapy, or radiation therapy. A slower cooling rate using a commercial semiprogrammable freezer may provide improved post-thaw motility and hypoosmotic swelling (HOS) test scores. However, the cost of this apparatus precludes it from being used in most andrology centers. This study compares the efficacy of slow stage cooling using an inexpensive cellevator (a device used to freeze lymphocytes) to liquid nitrogen vapor freezing. The semen from 27 males was equally divided and one aliquot was cryopreserved with the cellevator stage cooling and the other with the liquid nitrogen vapor technique. The percent motility and percent grade A sperm post-thaw were significantly higher when cryopreserved with the cellevator than with vapor freezing, as was the mean percentage of sperm showing HOS changes.
    Archives of Andrology 01/1996; 37(1):61-4. · 0.89 Impact Factor
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    ABSTRACT: This study evaluated the effects of pentoxifylline (PTX) on post-thaw semen parameters as well as the hypoosmotic swelling (HOS) test. Fourteen samples were evaluated for volume, count, motility, % grade A sperm, and HOS test. Two aliquots were frozen, one in freezing medium and the other in a 3 mM solution of PTX and freezing medium. Both groups were frozen in liquid nitrogen vapors for 30 min. Thawing was performed at 37°C for 15 min, followed by a wash with 2 parts 0.5% HSA/ MHTF to 1 part sample. Pellets were resuspended in 0. MHTF and then evaluated as described above. In addition, motility was evaluated 2 h post-thaw. Following freeze-thaw, the mean motile densities were similar (17.5 ± 10 motile/mL vs. 20.4 × 106 motile/mL for PTX and control, respectively). Two hours post-thaw, the PTX group had a mean sperm motility of 31.3% vs. 37.7% for the control group (p ±. 05). There were no significant differences in % grade A sperm in PTX (13.0%) vs. control (12.0%). Similarly, HOS scores did not improve following cryopreservation (43.0% and 50.6% for PTX and control, respectively). Thus, no improvement was found by freezing sperm with PTX.
    Systems Biology in Reproductive Medicine - SYST BIOL REPROD MED. 01/1995; 35(3):161-163.
  • Source
    D J Check, D Katsoff, J H Check
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    ABSTRACT: Cryopreservation and thawing of sperm exerts an adverse effect on functional integrity of the sperm membrane as measured by the hypoosmotic swelling (HOS) test. Supercooling using the liquid nitrogen (LN2) vapor technique may damage membranes by favoring ice crystal formation. Slight slowing of the cooling process may allow escape of intracellular fluid. This study was conducted to evaluate modification of the LN2 vapor technique by employing an intermediate hold in a freezer (to slow down the rate of cooling) on HOS scores on specimens thawed 1 month after freezing. Semen samples were obtained from male partners of infertile couples with a requirement of a baseline HOS score < 70% but > or = 60%. The HOS test was performed on the unprepared semen sample prior to freezing and immediately post-thaw 1 month later on the aliquot frozen with LN2 vapors only vs. the equal fraction subjected to an intermediate hold. The mean initial HOS score was 68.5% and was 47% in thawed specimens that had been cryopreserved with and without an intermediate hold. There were no differences in the percentage of specimens exhibiting a > 50% HOS score following vapor freeze (70%) or vapor freeze with a hold (74%). Thus, these data do not demonstrate any advantage of slowing the vapor freezing process by utilizing an intermediate hold.
    Archives of Andrology 01/1995; 35(1):79-81. · 0.89 Impact Factor
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    ABSTRACT: Cryopreservation of human sperm using present methods leads to a reduced fertility potential of the specimen. In many instances this prevents the successful fertilization of the female partner from the frozen-thawed specimens of males whose semen has been cryopreserved prior to surgery, chemo-therapy, or even vasectomy. Furthermore, even though some donor specimens can be successfully used for achieving pregnancies, one needs to place the sperm intrauterine to approach the same pregnancy rates as those of fresh intracervical insemination. The main mechanism considered for sperm damage by cryopreservation is ice crystal formation. The most critical time for forming ice crystals is from 0 to -10 degrees C. In the present study the effect of a modified rapid cryopreservation technique with reduction of exposure time to the 0 to -10 degrees C temperature range was compared to standard freezing procedures on subsequent semen parameters. Though no significant differences were found on post-thaw motile densities or hypoosmotic swelling test scores, a new, equally effective, but more rapid technique for cryopreservation is reported.
    Archives of Andrology 01/1994; 32(1):63-7. · 0.89 Impact Factor
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    ABSTRACT: Previous data has shown that subnormal motility in some semen specimens can be improved by the addition of fresh human seminal plasma (HSP). However, if the HSP was first frozen the motility-enhancing factor was lost. We hypothesized that some of the reduction in sperm motility of cryopreserved-thawed sperm may be related to damage of the "motility-enhancing factor" of HSP. This study evaluated whether the addition of fresh HSP could improve the motility of frozen-thawed sperm. Each frozen-thawed specimen was evaluated for motile density and hypoosmotic swelling and then divided into two aliquots. Equal volumes of HSP, human tubal fluid (HTF), and control media were added and the semen parameters were reevaluated. The mean scores for motile density and percent motility did not change compared with baseline thawed volumes with either HSP or HTF additives. There were some isolated cases that did improve with either HSP (21%) or HTF (14%). Future studies are needed to determine whether this improvement is coincidental or consistent, and to determine whether at least some individuals can benefit from the addition of fresh HSP to frozen-thawed sperm.
    Archives of Andrology 01/1993; 31(2):121-5. · 0.89 Impact Factor

Publication Stats

20 Citations
9.56 Total Impact Points

Institutions

  • 1993–2011
    • Cooper University Hospital
      • Department of Obstetrics and Gynecology
      Camden, New Jersey, United States
  • 1991–1996
    • Robert Wood Johnson University Hospital
      New Brunswick, New Jersey, United States