Mercedes Gómez-Morales

Publications (3)7.98 Total impact

• Article: Successful use of tocilizumab in a patient with nephrotic syndrome due to a rapidly progressing AA amyloidosis secondary to latent tuberculosis.

  César Magro-Checa, Antonio Navas-Parejo Casado, Elena Borrego-García, Enrique Raya-Álvarez, José Luis Rosales-Alexander, Juan Salvatierra, Trinidad Caballero-Morales, Mercedes Gómez-Morales
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  ABSTRACT: AA (secondary) amyloidosis is one of the most severe and uncommon complications of several rheumatic disorders and chronic infections such as tuberculosis (TB). Successful treatment depends on the control of the underlying inflammatory process, what can lead to an improvement or a regression in organ dysfunction. If the disorder persists, it has been reported in some cases of AA amyloidosis secondary to rheumatic diseases, that the use of biologic therapy is so far the only opportunity to reduce the development of AA amyloidosis and to reverse established deposits. We report herein a case of a latent TB infection complicated by a life-threatening AA amyloidosis presented as nephrotic syndrome. After an adequate antituberculostatic treatment, AA amyloidosis remained active and Tocilizumab (TCZ) was started with a dramatic resolution of the proteinuria, stabilization of the amyloid deposits and improvement in general condition.
  Amyloid: the international journal of experimental and clinical investigation: the official journal of the International Society of Amyloidosis 12/2011; 18(4):235-9. · 2.12 Impact Factor
• Source

  Available from: Jose Aneiros-Fernandez

  Article: Multifocal oral melanoacanthoma and melanotic macula in a patient after dental implant surgery.

  Pablo Galindo-Moreno, Miguel Padial-Molina, Mercedes Gómez-Morales, José Aneiros-Fernández, Francisco Mesa, Francisco O'Valle
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  ABSTRACT: Oral melanoacanthoma (OMA) is an uncommon, reactive, pigmented mucocutaneous lesion. It is a rapidly growing, well-circumscribed, small, brown-to-black, solitary or multifocal macule that is characterized histopathologically by proliferation of keratinocytes and pigment-laden dendritic melanocytes. At the end of a one-month healing period after dental implant surgery, a 63-year-old white woman had pigmented lesions at different oral mucosal sites (hard palate, buccal mucosa and left maxillary tuberosity) that showed macrophages exhibiting iron and melanin in multiple areas of the lamina propria. The authors obtained biopsy specimens from all the lesions for histologic and immunohistochemical analyses and light-microscopy study. Surgery could have been causal or incidental to the appearance of these lesions. Clinicians should be aware of this possible event and make a correct and pathologically confirmed differential diagnosis.
  Journal of the American Dental Association (1939) 07/2011; 142(7):817-24. · 1.77 Impact Factor
• Source

  Available from: Daniel Serón

  Article: Poly[ADP-ribose] polymerase-1 expression is related to cold ischemia, acute tubular necrosis, and delayed renal function in kidney transplantation.

  Francisco O'Valle, Raimundo G M Del Moral, María del Carmén Benítez, David Martín-Oliva, Mercedes Gómez-Morales, David Aguilar, José Aneiros-Fernández, Pedro Hernández-Cortés, Antonio Osuna, Francesc Moreso, Daniel Serón, Francisco J Oliver, Raimundo G Del Moral
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  ABSTRACT: Cold ischemia time especially impacts on outcomes of expanded-criteria donor (ECD) transplantation. Ischemia-reperfusion (IR) injury produces excessive poly[ADP-Ribose] Polymerase-1 (PARP-1) activation. The present study explored the hypothesis that increased tubular expression of PARP-1 contributes to delayed renal function in suboptimal ECD kidney allografts and in non-ECD allografts that develop posttransplant acute tubular necrosis (ATN). MATERIALS AND METHODS: Nuclear PARP-1 immunohistochemical expression was studied in 326 paraffin-embedded renal allograft biopsies (193 with different degrees of ATN and 133 controls) and in murine Parp-1 knockout model of IR injury. RESULTS: PARP-1 expression showed a significant relationship with cold ischemia time (r coefficient = 0.603), time to effective diuresis (r = 0.770), serum creatinine levels at biopsy (r = 0.649), and degree of ATN (r = 0.810) (p = 0.001, Pearson test). In the murine IR model, western blot showed an increase in PARP-1 that was blocked by Parp-1 inhibitor. Immunohistochemical study of PARP-1 in kidney allograft biopsies would allow early detection of possible delayed renal function, and the administration of PARP-1 inhibitors may offer a therapeutic option to reduce damage from IR in donor kidneys by preventing or minimizing ATN. In summary, these results suggest a pivotal role for PARP-1 in the ATN of renal transplantation. We propose the immunohistochemical assessment of PARP-1 in kidney allograft biopsies for early detection of a possible delayed renal function.
  PLoS ONE 01/2009; 4(9):e7138. · 4.09 Impact Factor