Ki Young Kim

Yonsei University Hospital, Sŏul, Seoul, South Korea

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Publications (139)115.89 Total impact

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    ABSTRACT: Background The migration of vascular smooth muscle cells from the tunica media to the subendothelial region may be a key event in the development of atherosclerosis after arterial injury. In this study, we investigated the potential mechanisms underlying the anti-atherosclerotic effects of Schisandrae Semen essential oil (SSeo) in human aortic smooth muscle cells (HASMCs).Methods Metalloproteinase-2/9 (MMP-2/9) activity was evaluated by gelatin zymography and gelatinase activity assay kit. The possible mechanisms underlying SSeo-mediated reduction of by tumor necrosis factor (TNF)-¿-induced cell invasion and inhibition of secreted and cytosolic MMP-9 production in HASMCs were investigated.ResultsOur results indicate that SSeo treatment has an inhibitory effect on activation as well as expression of MMP-9 induced by TNF-¿ in HASMCs in a dose-dependent manner without significant cytotoxicity. SSeo attenuated nuclear translocation of TNF-¿-mediated nuclear factor-kappa B (NF-¿B) and blocked degradation of the NF-¿B inhibitor proteins as well as the production of reactive oxygen species. SSeo also reduced TNF-¿-induced production of pro-inflammatory mediators such as nitric oxide and prostaglandin E2 and inhibited inducible nitric oxide synthase and cyclooxygenase-2 expression in HASMCs. Furthermore, the Matrigel migration assay showed that SSeo effectively reduced TNF-¿-induced HASMC migration compared with that in the control group.Conclusions Taken together, these results suggest that SSeo treatment suppresses TNF-¿-induced HASMC migration by selectively inhibiting MMP-9 expression, which was associated with suppression of the NF-¿B signaling pathway. Taken together, these results suggest that SSeo has putative potential anti-atherosclerotic activity.
    BMC Complementary and Alternative Medicine 02/2015; 15(1):7. DOI:10.1186/s12906-015-0523-9 · 1.88 Impact Factor
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    ABSTRACT: To determine the cutoff value of the pharyngeal residue for predicting reduction of aspiration, by measuring the residue of valleculae and pyriformis sinuses through videofluoroscopic swallowing studies (VFSS) after treatment with neuromuscular electrical stimulator (VitalStim) in stroke patients with dysphagia.
    10/2014; 38(5):612-9. DOI:10.5535/arm.2014.38.5.612
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    ABSTRACT: The aim of the present study was to investigate the optimum composition of Polycan (β-glucan complex) and calcium lactate-gluconate (CaLG) that exhibited the most beneficial effects in ovariectomy (OVX)-induced osteoporotic rats. Polycan and CaLG single formulas (100 mg/kg each), and three doses (50, 100 and 200 mg/kg) of three mixed formulas [polycan:CaLG (PCLG)=1:99, 5:95 and 10:90] were orally administered once a day for 84 days. The effects of the test materials were compared with those of a risedronate sodium-treated group. OVX resulted in an increase in body weight, decreased bone formation, elevated serum osteocalcin levels and urine deoxypyridinoline/creatinine ratio, as well as decreased serum bone-specific alkaline phosphatase levels, femur indices, bone mineral content, bone mineral density and failure load. However, these OVX-induced osteoporotic changes markedly decreased following the administration of the test materials. Continuous oral treatment of Polycan or CaLG single formulas and the PCLG mixed formulas preserved bone mass and strength. The PCLG 10:90 mixed formula exhibited the most favorable synergistic antiosteoporotic effects in the OVX-induced osteoporotic rats as compared with equal doses of the Polycan or CaLG single formulas.
    Experimental and therapeutic medicine 09/2014; 8(3):957-967. DOI:10.3892/etm.2014.1793 · 0.94 Impact Factor
  • Iseul Park, Ki Young Kim
    05/2014; 17(2):66-73. DOI:10.7582/GGE.2014.17.2.066
  • Arim Han, Keehoon Kim, Ki Young Kim
    05/2014; 17(2):58-65. DOI:10.7582/GGE.2014.17.2.058
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    ABSTRACT: A novel high-Q resonant structure comprising the bulk acoustic resonator (BAR) and inductive loop is proposed to be used for wireless power transmission system. The proposed resonant structure operating at MHz frequency range has significantly miniature size in relation to the electrical wavelength (
    Microwave and Optical Technology Letters 03/2014; 56(3). DOI:10.1002/mop.28153 · 0.62 Impact Factor
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    JinHoon Jung, Ki Young Kim
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    ABSTRACT: To reveal and classify site characteristics in densely populated areas in Chuncheon, Korea, Rayleigh-waves were recorded at 50 sites including four sites in the forest area using four 1-Hz velocity sensors and 24 4.5-Hz vertical geophones during the period of January 2011 to May 2013. Dispersion curves of the Rayleigh waves obtained by the extended spatial autocorrelation method were inverted to derive shear-wave velocity () models comprising 40 horizontal layers of 1-m thickness. Depths to weathered rocks (), shear wave velocities of these basement rocks (), average velocities of the overburden layer (), and the average velocity to a depth of 30 m (), were then derived from those models. The estimated values of , , , and for 46 sites at lower altitudes were in the ranges of 5 to 29 m, 404 to 561 m/s, 208 to 375 ms/s, and 226 to 583 m/s, respectively. According to the Korean building code for seismic design, the estimated indicates that the lower altitude areas in Chuncheon are classified as (very dense soil and soft rock) or (stiff soil). To determine adequate proxies for , we compared the computed values with land cover, lithology, topographic slope, and surface elevation at each of the measurement sites. Due to a weak correlation (r = 0.41) between and elevation, the best proxy of them, applications of this proxy to Chuncheon of a relatively small area seem to be limited.
    02/2014; 17(1). DOI:10.7582/GGE.2014.17.1.001
  • Chungho Kim, Abid Ali, Ki Young Kim
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    ABSTRACT: To reveal shear-wave velocities () and site characterization of Wonju, Korea, Rayleigh waves were recorded at 78 sites of lower altitude using 12 to 24 4.5-Hz vertical geophones for 20 days during the period of February to September 2013. Dispersion curves of the Rayleigh waves obtained by the extended spatial autocorrelation method were inverted using the damped least-squares method to derive models. From these 1-D models, the average to a depth of 30 m (), of weathered rocks, depths to these basement rocks, and average of the overburden layer were derived to be , , , and , respectively, in the 95% confidence range. To determine adequate proxies for , we computed correlation coefficients of with topographic slope (r = 0.46) and elevation (r = 0.43). An empirical linear relationship is presented as a combination of individually estimated with weighting factors of 0.45, 0.45, and 0.1 for topographic slope, elevation, and mapped lithology, respectively. Due to a weak correlation between obtained from inversion of dispersion curves and the proxy-based estimation (r = 0.50), however, the relatively large error range should be considered for applications of this relationship.
    02/2014; 17(1). DOI:10.7582/GGE.2014.17.1.011
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    ABSTRACT: Essential oils extracted or purified from various plants have shown various beneficial effects. Seed parts of Schizandra chinensis Baillon (Schisandrae Semen) have been used as a traditional medicine for thousands of years in parts of Asia, including Korea, China, and Japan. However, the pharmacological mechanisms of essential oils purified from S. fructus (S. chinensis Baillon) remain largely unresolved. The aim of this study was to investigate the safety of Schisandrae Semen essential oil (SSeo) by a single- dose toxicity study in mice. SSeo was orally administered at a dose of 5,000 mg/kg in ICR mice. All animals were sacrificed after 14 days of treatment. After a single administration, mortality, clinical signs, body weight changes, and gross pathological findings were observed for 14 days. We also measured parameters of organ weight, clinical chemistry, and hematology. No toxicological change related to the test substance or mortality was observed after administration of a single oral dose of SSeo. There were no adverse effects on clinical signs, body weight, or organ weight and no gross pathological findings in any treatment group. The clinical chemistry and hematological parameters were within the normal ranges except total bilirubin. Therefore, the approximate lethal dose for oral administration of SSeo in mice was considered to be over 5,000 mg/kg. The results on the single-dose toxicity of SSeo indicate that it is not possible to reach oral dose levels related to death or dose levels with any harmful side effects.
    02/2014; 24(2). DOI:10.5352/JLS.2014.24.2.191
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    ABSTRACT: To examine the antioxidant activities of 11n selected miscellaneous cereal grains (proso millet, yellow glutinous proso millet, hwanggeumchal sorghum, glutinous sorghum, white glutinous sorghum, yellow glutinous foxtail millet, nonglutinous foxtail millet, green glutinous foxtail millet, golden foxtail millet, barnyard millet, and adlay), the free radical-scavenging activities of 80% ethanol extracts of the individual grains were investigated using 1,1-diphenyl-2-picryl-hydrazl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) methods. The ethanol extracts of hwanggeumchal sorghum, glutinous sorghum, and barnyard millet grains exhibited more potent free radical-scavenging activities as compared to the other grains. When these three ethanol extracts were sequentially fractionated with n-hexane, methylene chloride, ethyl acetate, and n-butanol, the majority of the antioxidant activities were detected in the ethyl acetate and butanol fractions in which phenolic ingredients were abundant. The ethyl acetate and butanol fractions of hwanggeumchal sorghum and the ethyl acetate fraction of glutinous sorghum showed higher antioxidant activity than that of -tocopherol. Both ferric thiocyanate (FTC) and thiobarbituric acid (TBA) methods demonstrated that these organic solvent fractions could inhibit lipid peroxidation. The ethyl acetate fractions from hwanggeumchal sorghum, glutinous sorghum, and barnyard millet grains could suppress tertiary-butyl hydroperoxide (TBHP)-induced apoptotic events, including sub-G1 peaks, loss, activation of caspase-9 and caspase-3, and cleavage of PARP and lamin B, in human HL-60 cells. These results show that the grains of hwanggeumchal sorghum (Sorghum bicolor L. Moench cv. Hwanggeumchalsusu), glutinous sorghum (Sorghum bicolor L. Moench cv. Chalsusu), and barnyard millet (Echinochloa esculenta) possess efficient antioxidant activity, which could protect cells from oxidative stress-mediated cytotoxicity.
    01/2014; 24(1). DOI:10.5352/JLS.2014.24.1.26
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    ABSTRACT: The purpose of this study is to develop a lightweight and environmentally friendly nonwoven fabric to substitute polyurethane (PU) foams in automotive interiors. Two types of hollow fibers-polyethylene terephthalate (PET) hollow fiber and polylactic acid (PLA) hollow fiber-and bicomponent binder fibers were used to manufacture the nonwoven fabrics for seat cushions by carding, needle punching, thermal bonding, and air through bonding processes. The ideal characteristics required for automotive seat cushions were evaluated, and the significant changes with the structural components were analyzed. The nonwoven fabrics showed better air permeability, compressional resilience, ball rebound resilience, and non-flammability in comparison with PU foams. The characteristics were affected by the manufacturing processes.
    12/2013; 50(6). DOI:10.12772/TSE.2013.50.366
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    ABSTRACT: The purpose of this study was to evaluate the physicochemical characteristic of the cooked rice added with glutinous and non-glutinous sorghum. The sorghum cultivars were Sorghum bicolor L. Moench cv. Hwanggeumchal, Nampungchal (glutinous), and Donganme (nonglutinous), and rice cultivar was Ilpum rice. The cooking properties and pasting characteristics of cooking rice adding with sorghum according to varieties and different addition rates evaluated. The cooking properties and pasting characteristics had significant changes with the varieties and different addition rates of sorghum. With increased addition rates of sorghum, the pasting temperature, peak viscosity, trough viscosity, breakdown viscosity, and final viscosity were decreased. With increased addition rates of sorghum, the total polyphenol and flavonoid contents before and after cooked rice were increased. Total polyphenol contents of 30% addition rates before cooking rice with Hwanggeumchal, Nampungchal, and Donganme sorghum were 1,693.30, 1,890.98 and sample, whereas those after cooking rice with sorghum were 1,189.28, 1,190.42 and sample, respectively. The high level of DPPH radical scavenging activity before and after cooking rice with sorghum were 126.29 and 70.58 mg TE/100g sample in the Donganme in 30% addition rates. Also, ABTS radical scavenging activity was 135.56 and 83.12 mg TE/100g sample, respectively. The results of this study show that the addition of sorghum can make cooked rice improved antioxidant activity.
    12/2013; 58(4). DOI:10.7740/kjcs.2013.58.4.399
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    ABSTRACT: Numerous efforts to prepare useful graphene-based nanocomposites have been made and important improvements achieved. In our studies, novel structured polyolefin-based thermoplastic elastomer, poly(ethylene-ter-1-hexene-ter-divinylbenzene) (PEHV) was designed and synthesized. And high quality graphene was manufactured via the exfoliation of graphite. PEHV/graphene nanocomposites were fabricated using solution casting method as the amount of graphene added. The morphologies of nanocomposites were observed using scanning electron microscopy. And density, mechanical properties and electrical properties were also measured. Electrical properties and mechanical properties were improved with the increase of graphene added in nanocomposites. It is expected that PEHV/graphene nanocomposites could be applied to lightweight EMI shielding materials.
    Fibers and Polymers 12/2013; 14(12). DOI:10.1007/s12221-013-2117-9 · 1.11 Impact Factor
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    ABSTRACT: To study the effects of short carbon fiber (SCF) on the properties of the polyolefin elastomers (POEs), we prepared the poly(ethylene-co-1-hexene) (PEH)/SCF composites at different percentages of SCF. We also prepared polyethylene (PE)/SCF composites to compare with PEH/SCF composites. PEH was synthesized by the copolymerization of ethylene and 1-hexene using metallocene catalyst/cocatalyst system. Optimum stirring speed, Al/Zr feeding molar ratio, polymerization time, and polymerization temperature were 700 rpm, 600, 30 min, and 60 °C, respectively. We investigated the morphology of the composites using scanning electron microscopy (SEM) and found that the wettability of SCF in PEH/SCF composites was fairly better than that of SCF in PE/SCF composites. It was observed from mechanical tests that the ultimate tensile strength and tensile modulus of PEH/SCF composites were remarkably enhanced as the SCF content increased, whereas those of PE/SCF composites were a little increased. PEH/SCF composites exhibited lower crystallinity than PE/SCF ones. Thermal stability of the composites was enhanced by the addition of SCF.
    Fibers and Polymers 12/2013; 14(12). DOI:10.1007/s12221-013-2128-6 · 1.11 Impact Factor
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    Arim Han, Iseul Park, Ki Young Kim
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    ABSTRACT: Continuous seismic observation of volcanic earthquakes related to migration of magma or gas, is one of the most important methods used to monitor active volcanoes. In this review paper, we introduce the characteristics of volcanic earthquakes and their classification based on locations of foci, waveforms, frequencies, lithology, and source mechanisms. We also present some examples of successful warnings of volcanic eruptions and the present status of some observations of volcanic earthquakes in Japan, the United States, Italy, and New Zealand.
    11/2013; 16(4). DOI:10.7582/GGE.2013.16.4.268
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    Won Young Yun, Sun-Cheon Park, Ki Young Kim
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    ABSTRACT: To look into site characteristics of the Hwacheon borehole seismic station, we analyzed property of earthquake and microtremor recorded on surface and borehole seismometers. Acoording to analysis result of microtremor, the surface-to-borehole energy ratio was approximately 15 times greater during the daytime than during the nighttime, and the surface-to-borehole ratios of spectral amplitudes as frequency increases. For earthquake data, amplitude spectra and dominant frequency were computed using surface and borehole data. As a result, small earthquakes with short distance recorded on surface seismometer peaked at 8 Hz, 46 Hz. This result corresponds to resonance frequencies (7.4 Hz, 46 Hz) calculated by H/V spectral ratio. We confirmed amplification effect by site characteristics of overburden. Background noise level was approximately 20,000 times smaller at borehole seismic station than surface seismic station. These results provide strong evidence for the superior recording of earthquakes using borehole seismometers instead of surface seismometers.
    11/2013; 16(4). DOI:10.7582/GGE.2013.16.4.203
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    ABSTRACT: This study was conducted in order to investigate the quality characteristics and antioxidant activities of dry noodles with addition of sorghum (Sorghum bicolor L. Moench) flour from glutinous and non-glutinous varieties. The sorghum varieties used in this study were glutinous 'Hwaggumchal' and non-glutinous 'Donganme', and the contents added to noodles were 'Hwaggumchal' 5%, 'Hwaggumchal' 10%, 'Donganme' 5%, and 'Donganme' 10%. The turbidity of soup of cooked noodles was increased by addition of sorghum flour. The cooking loss of 'Hwaggumchal' flour added noodles (HFN) was greater than that of 'Donganme' flour added noodles (DFN), reflecting endosperm characteristics. Phenolic compounds such as polyphenol, flavonoid, and tannin contents and antioxidant activity of sorghum flour added noodles were increased in proportion to the amounts of added sorghum flour. In the added varieties, DFN showed greater amounts of phenolic compounds and higher levels of DPPH and ABTS radical scavenging activities than HFN. The DPPH and ABTS radical scavenging activities of 5~10% DFN were increased by 4.6~6.2 fold and 10.5~13.4 fold, respectively, compared to non-added noodles. Regarding cooking effects, DPPH and ABTS radical scavenging activities of sorghum flour added noodles were increased by 10.9~11.2% after cooking. In sensory evaluation, color and appearance value were highest in HFN, and no differences in taste and overall acceptability were observed among treatments.
    Journal of the Korean Society of Food Science and Nutrition 08/2013; 42(8). DOI:10.3746/jkfn.2013.42.8.1227
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    Won Young Yun, Sun-Cheon Park, Ki Young Kim
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    ABSTRACT: We estimated near-surface shear-wave velocity () at the Hwacheon seismic station using a geologic log of a well, microtremors recorded during a period of 56 days, and records of three teleseismic events (). The vs of the 10-m thick soil layer (= 296 m/s) was determined from horizontal-to-vertical spectral ratios of microtremors recorded at the surface. The average (= 1,309 m/s) from the surface to the 96-m depth of a borehole sensor, was computed using spectral coherence analyses of data recorded by surface- and borehole-sensors for the three teleseismic events. Using these calculated values of and , the computed bedrock is 2,150 m/s and the time-averaged to a 30-m depth is 696 m/s. Accordingly the Hwacheon seismic station is regarded as a relatively good site. The deduced near-surface can be used for further quantitative evaluation of site amplification and earthquake hazard.
    08/2013; 16(3). DOI:10.7582/GGE.2013.16.3.190
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    Yeong Hwan Park, Ki Young Kim
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    ABSTRACT: On and near the 23-m high earthen Cheongcheon dam in Boryeong City, Korea, short seismic refraction and surface-wave profiles were conducted using a 5-kg sledgehammer. From vertical and horizontal components of the seismic waves, near-surface P-wave velocities () and S-wave velocities () were derived by inverting first-arrival refraction times and dispersion curves of Rayleigh waves. Average and for the Jurassic sedimentary basement were determined to be 1650 and 950 m/s at a depth of 30 m directly beneath the dam and 1650 m/s and 940 m/s at a depth of 10 m at the toe of the dam, respectively. The dynamic Poisson's ratio for these strata were therefore in the range of 0.24 to 0.25, which is consistent with ratios for consolidated sedimentary strata. Near a 45-m borehole 152 m downstream from the dam crest, an SH tomogram indicates a refraction boundary with an average of 870 m/s at depths of 10 ~ 12 m. At this site, the overburden comprises the upper layer with relatively constant and around 500 and 200 m/s, respectively, and the lower layer in which both and increase with depth almost linearly. The dynamic Poisson's ratios for the overburden were in the range of 0.30 to 0.43.
    08/2013; 16(3). DOI:10.7582/GGE.2013.16.3.109
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    ABSTRACT: This study examined the effects of calcium (Ca) gluconate on collagen-induced DBA mouse rheumatoid arthritis (CIA). A single daily dose of 200, 100 or 50 mg/kg Ca gluconate was administered orally to male DBA/1J mice for 40 days after initial collagen immunization. To ascertain the effects administering the collagen booster, CIA-related features (including body weight, poly-arthritis, knee and paw thickness, and paw weight increase) were measured from histopathological changes in the spleen, left popliteal lymph node, third digit and the knee joint regions. CIA-related bone and cartilage damage improved significantly in the Ca gluconate- administered CIA mice. Additionally, myeloperoxidase (MPO) levels in the paw were reduced in Ca gluconate-treated CIA mice compared to CIA control groups. The level of malondialdehyde (MDA), an indicator of oxidative stress, decreased in a dosedependent manner in the Ca gluconate group. Finally, the production of IL-6 and TNF-α, involved in rheumatoid arthritis pathogenesis, were suppressed by treatment with Ca gluconate. Taken together, these results suggest that Ca gluconate is a promising candidate anti-rheumatoid arthritis agent, exerting anti-inflammatory, anti-oxidative and immunomodulatory effects in CIA mice.
    Biomolecules and Therapeutics 07/2013; 21(4):290-8. DOI:10.4062/biomolther.2013.040 · 0.84 Impact Factor

Publication Stats

800 Citations
115.89 Total Impact Points

Institutions

  • 2014
    • Yonsei University Hospital
      Sŏul, Seoul, South Korea
  • 2012–2014
    • Samsung Advanced Institute of Technology
      Usan-ri, Gyeonggi-do, South Korea
  • 2004–2013
    • Korea Institute of Industrial Technology
      Anzan, Gyeonggi Province, South Korea
  • 2000–2012
    • Kyungpook National University
      • • School of Computer Science and Engineering
      • • Department of Microbiology
      • • Department of Electronic Engineering
      • • Department of Electrical Engineering
      Daikyū, Daegu, South Korea
  • 2011
    • Sejong University
      Sŏul, Seoul, South Korea
  • 2010
    • Korea Institute of Science and Technology
      Sŏul, Seoul, South Korea
  • 1994–2010
    • Korea Advanced Institute of Science and Technology
      • • Department of Electrical Engineering
      • • Department of Chemical and Biomolecular Engineering
      Sŏul, Seoul, South Korea
  • 2009
    • Hyundai Motor Company
      Sŏul, Seoul, South Korea
    • National Institute of Crop Science
      Sŏngnam, Gyeonggi Province, South Korea
    • Korea Institute of Energy Research
      Sŏul, Seoul, South Korea
    • National Cheng Kung University
      • Department of Physics
      臺南市, Taiwan, Taiwan
    • Hanyang University
      • Department of Industrial Engineering
      Sŏul, Seoul, South Korea
  • 2007–2009
    • Northwestern University
      • Department of Electrical Engineering and Computer Science
      Evanston, Illinois, United States
  • 2001–2009
    • Chung-Ang University
      • School of Mechanical Engineering
      Seoul, Seoul, South Korea
  • 2008
    • Union Corporation, South Korea
      Sŏul, Seoul, South Korea
  • 2003–2007
    • Dongseo University
      • Department of International Logistics
      Tsau-liang-hai, Busan, South Korea
    • Sungkyunkwan University
      • Department of Chemical Engineering
      Sŏul, Seoul, South Korea
  • 2006
    • Electronics and Telecommunications Research Institute
      Sŏul, Seoul, South Korea
  • 2003–2006
    • Information and Communications University
      Daiden, Daejeon, South Korea
  • 2002–2006
    • Konyang University Hospital
      Gaigeturi, Jeju, South Korea
  • 1997–2005
    • Pusan National University
      • • Department of Atmospheric Sciences
      • • Department of Industrial Engineering
      Tsau-liang-hai, Busan, South Korea
  • 1999
    • Yeungnam University
      • College of Medicine
      Daikyū, Daegu, South Korea