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Publications (2)5.27 Total impact

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    ABSTRACT: Retinol is a cosmetic ingredient that is structurally similar to all-trans-retinoic acid, which has been shown to be effective in the treatment of photodamage. Since skin keratinocytes are reported to metabolize retinol to retinoic acid, investigators have hypothesized that retinol may also be helpful in improving skin photodamage. In this eight-week, double-blind, split-face, randomized clinical study, a stabilized 0.1% retinol-containing moisturizer was tested (36 subjects) against the vehicle (28 subjects) in women with moderate facial photodamage. Each product was applied once daily to the designated half side of the face. Subjects were evaluated at baseline and after four and eight weeks of treatment using a 0-9 scale for photoaging parameters. The results showed that, after eight weeks, the retinol moisturizer was significantly more efficacious than the vehicle in improving lines and wrinkles, pigmentation, elasticity, firmness and overall photodamage. Many of these differences were significant at week 4, with a progressive improvement to week 8. This study demonstrates that a formulation containing stabilized retinol is safe and effective to ameliorate the appearance of photoaged skin.
    Journal of drugs in dermatology: JDD 10/2009; 8(10):932-6. · 1.32 Impact Factor
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    ABSTRACT: Antisense-based screening strategies can be used to sensitize a microorganism and selectively detect inhibitors against a particular cellular target of interest. A strain of Staphylococcus aureus that generates an antisense RNA against SecA,a central member of the protein secretion machinery, has been used to screen for novel antibacterials. Possible inhibitors of the SecA ATP-ase were selected with a high-throughput, two-plate agar-based whole cell differential sensitivity screen. After screening a library of over 115 000 natural products extracts with the SecA antisense strain, an extract of Geomyces pannorum was identified as providing increased activity against the sensitized strain as compared with the wild-type control. Bioassay-guided isolation of the active component from this fungal extract provided a new cis-decalin secondary metabolite, which we have named pannomycin.
    Journal of Natural Products 01/2009; 72(1):59-62. · 3.95 Impact Factor