Mohammad Sahraian

Publications (2)2.89 Total impact

• Article: Warning signs and symptoms of subarachnoid hemorrhage.

  Mansooreh Togha, Mohammad Ali Sahraian, Majid Khorram, Patricia Khashayar
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  ABSTRACT: The objective of this study was to assess the warning signs and symptoms in patients with spontaneous subarachnoid hemorrhage (SAH). Patients admitted with spontaneous SAH were enrolled in the study and were asked for their history of frequent warning signs and symptoms as cited in other studies. Overall, 28 cases of spontaneous SAH were identified during the study period. A history of headache as the most frequent warning symptom was present in 64.3% of the cases. Transient loss of consciousness (42.8%), difficulty in walking (21.4%), hemiparesis (14.2%), ocular signs (14.2%) and seizure (3.6%) were the next most frequent symptoms. Hypertension and smoking, the most frequent risk factors for SAH, were found in 39.3 and 32.1% of the cases, respectively. Despite recent advances in neurosurgical techniques, the overall outcome after aneurysmal SAH remains poor. Sudden, severe onset of headache with or without neurologic deficits is an important warning symptom for spontaneous subarachnoid hemorrhage. Further reduction of the possible risk factors and earlier diagnosis on the basis of warning symptoms and treatments are desirable.
  Southern medical journal 01/2009; 102(1):21-4. · 0.92 Impact Factor
• Source

  Available from: Mojdeh Ghabaee

  Article: Mitochondrial mutation in Iranian patients with multiple sclerosis, correlation between haplogroups H, A and clinical manifestations.

  Mojdeh Ghabaee, Motahar Omranisikaroudi, Shahla Amrisaroukolaei, Alipasha Meysamie, Mohammad Ali Sahraian, Asghar Bayati, Mohammad Hossein Sanati, Mossoud Houshman, Homa Sadeghian, Khalili Vajihazaman
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  ABSTRACT: As multiple sclerosis (MS) has long been known to be associated with Leber, hereditary optic neuropathy (LHON), a disease caused by mitochondrial (mtDNA) mutations, in this study we assessed possible involvement of mtDNA point mutation in MS patients. Fifty-two MS patients whose disease was confirmed with revised McDonald criteria and referred to Iranian Center of Neurological Research of Imam Khomeini hospital during 2006-2007 entered the study. Secondary mtDNA mutations, age, gender, clinical disability according to expanded disability status scale (EDSS), course of the disease, and presenting symptoms were the variables investigated in this study. DNA purification was performed by Diatom DNA Extraction Kit. Analysis of data was done by SPSS V11.5. The prevalent mutations with frequency of 19.2% were J, L, and T haplogroups. Haplotype A was more prevalent in patients with younger age of onset (P-value = 0.012) and high proportion of haplogroup H was associated with optic nerve involvement (P-value = 0.015). No motor symptoms were seen in haplogroup H patients. There is no significant relationship between duration of the disease and EDSS in different mutation of mtDNA.
  Cellular and Molecular Neurobiology 12/2008; 29(3):341-6. · 1.97 Impact Factor