Xin Wei

Indiana University Bloomington, Bloomington, IN, United States

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Publications (7)12.17 Total impact

  • Xin Wei, Larry N Thibos
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    ABSTRACT: Measuring the off-axis optical quality of the eye with a Shack-Hartmann wavefront sensor requires methods for reconstructing wavefront from the gradient data defined within an elliptical pupil. Such methods for modal estimation of wavefront aberrations are sensitive to pupil shape. We develop a conceptual framework that reconciles two published, but apparently dissimilar, methods for reconstruction over an elliptical pupil based on Zernike analysis. Our unified treatment shows that the two methods have different interpretations but the vectors of Zernike coefficients they produce are related linearly. Two novel methods based on Fourier series are also introduced for a model of gradient sensors based on Southwell geometry. All four methods were evaluated numerically with three test-cases: a defocus wavefront (1), a spherocylindrical wavefront (2), and a random-generated wavefront (3). Under noise-free conditions, all four methods reconstructed the tested wavefronts accurately. The reconstruction error is negligible at the level of numerical computation. Furthermore, the Monte-Carlo simulation with test case 2 revealed small differences in sensitivity to noise between the two Zernike methods but no difference between the two Fourier methods. Because of the smoothing effects, the two Zernike-based methods are more robust to noise than are the two Fourier methods. However, Fourier methods are computationally faster. All four modal methods are validated methods to reconstruct wavefronts from the gradients over the elliptical pupil. The choice of these methods is application dependent.
    Optometry and vision science: official publication of the American Academy of Optometry 10/2010; 87(10):E767-77. · 1.53 Impact Factor
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    Xin Wei, Larry Thibos
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    ABSTRACT: Peripheral vision and off-axis aberrations not only play an important role in daily visual tasks but may also influence eye growth and refractive development. Thus it is important to measure off-axis wavefront aberrations of human eyes objectively. To achieve efficient measurement, we incorporated a double-pass scanning system with a Shack Hartmann wavefront sensor (SHWS) to develop a scanning Shack Hartmann aberrometer (SSHA). The prototype SSHA successfully measured the off-axis wavefront aberrations over +/- 15 degree visual field within 7 seconds. In two validation experiments with a wide angle model eye, it measured change in defocus aberration accurately (<0.02microm, 4mm pupil) and precisely (<0.03microm, 4mm pupil). A preliminary experiment with a human subject suggests its feasibility in clinical applications.
    Optics Express 01/2010; 18(2):1134-43. · 3.55 Impact Factor
  • Xin Wei, Larry Thibos
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    ABSTRACT: PurposeCorrecting the off-axis wavefront aberration is potentially important for peripheral vision, for diagnostic imaging of the retina, and for influencing refractive development. A new technique called ocular wavefront tomography (OWT) was adapted to optimize the design of contact lenses to improve the eye's peripheral optical quality.
    Journal of Optometry. 01/2010; 3(3):125-133.
  • Xin Wei, Larry N. Thibos
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    ABSTRACT: We developed a Scanning Hartmann Shack wavefront sensor by coupling the Shack Hartmann aberrometer with a scanning system. This instrument measures off-axis aberration of the human eye accurately and precisely in an efficient manner.
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    ABSTRACT: Our goal was to validate the accuracy, repeatability, sensitivity, and dynamic range of a Hartmann-Moiré (HM) wavefront sensor (PixelOptics, Inc.) designed for ophthalmic applications. Methods: Testing apparatus injected a 4 mm diameter monochromatic (532 nm) beam of light into the wavefront sensor for measurement. Controlled amounts of defocus and astigmatism were introduced into the beam with calibrated spherical (-20D to + 18D) and cylindrical (-8D to + 8D) lenses. Repeatability was assessed with three repeated measurements within a 2-minute period. Results: Correlation coefficients between mean wavefront measurements (n = 3) and expected wavefront vergence for both sphere and cylinder lenses were >0.999. For spherical lenses, the sensor was accurate to within 0.1D over the range from -20D to + 18D. For cylindrical lenses, the sensor was accurate to within 0.1D over the range from -8D to + 8D. The primary limitation to demonstrating an even larger dynamic range was the increasingly critical requirements for optical alignment. Sensitivity to small changes of vergence was constant over the instrument's full dynamic range. Repeatability of measurements for fixed condition was within 0.01D. Conclusion: The Hartmann-Moiré wavefront sensor measures defocus and astigmatism accurately and repeatedly with good sensitivity over a large dynamic range required for ophthalmic applications.
    Optics Express 08/2009; 17(16):14180-5. · 3.55 Impact Factor
  • Xin Wei, Larry Thibos
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    ABSTRACT: Ocular wavefront tomography (OWT) is the process of using wavefront aberration maps obtained along multiple lines-of-sight (LoS) to determine the shape and position of the major refracting elements of an eye. One goal of OWT is to create a customized schematic model eye that is anatomically similar and functionally equivalent to the individual eye over a large field of view. Wavefront aberration maps along multiple LoS were used as design goals for configuring a generic, multi-surface model eye with aberrations that match the measurements. The model was constrained by gross anatomical dimensions and optimized to mimic the measured eye. The method was evaluated with two test cases: (1) a physical model eye with a doublet lens measured with a clinical wavefront aberrometer along six LoS between -31 deg and +29 deg eccentricities, and (2) a mathematical model of the myopic eye for which wavefront aberrations were computed by ray tracing. In case 1, the OWT algorithm successfully predicted the structure of the doublet model eye from the experimental on- and off-axis aberration measurements. In case 2, the algorithm started with a symmetric five surface model eye and optimized it to generate the on- and off-axis aberrations of a GRIN myopia model eye. The adjusted model closely mimicked the physical parameters and optical behavior of the expected myopia model eye over a large field of view. The maximum discrepancy between aberrations of the OWT optimized model and measurements was 0.05 microns RMS for test case 1 and 0.2 microns RMS for test case 2. Our implementation of OWT is a valid, feasible, and robust method for constructing an optical model that is anatomically and functionally similar to the eye over a wide field of view.
    Optics Express 01/2009; 16(25):20490-502. · 3.55 Impact Factor
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    ABSTRACT: We present a theoretical framework with the implementation in Matlab to simulate the retinal projection of far field scene across a large anisoplanatic visual field in object space via wide angle schematic eyes monochromatically.
    Frontiers in Optics; 10/2008

Publication Stats

21 Citations
12.17 Total Impact Points


  • 2009–2010
    • Indiana University Bloomington
      • School of Optometry
      Bloomington, IN, United States