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Xiao-Lin Xue,
Xiu-Yan Wu,
Jian-Min Xing,
Li Li,
Yan Zhao,
Jia-Jia Wang, Ya-Jing Zhang,
Qing-Bo Wang,
Yu Tang,
Guan-Ru Li,
Ping Han,
Zhen Li,
Wen-Ping Wang,
Tian-Fang Wang
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ABSTRACT: To observe the effects of Xiaopiyishen Herbal Extract Granule (XPYS-HEG) on the quality of life in people with fatigue-predominant subhealth (FPSH) and liver-qi stagnation and spleen-qi deficiency syndrome, the participants were allocated randomly to the treatment group (XPYS, n = 100) and the control group (placebo, n = 100) in this study. The study period was 18 weeks (6 weeks for the intervention and 12 weeks for followup). The results show that there were no differences between the two groups for the scores of eight factors on the SF-36 (Chinese version of the SF-36 universal quality-of-life scale) at baseline. Compared with the baseline score, intervention with XPYS-HEG led to a significant increase in scores for the factor of bodily pain at the end of the 6th week. Compared with the score at the end of the 6th week, the score for the factor of mental health in the XPYS group significantly increased at the end of the 18th week. Therefore, XPYS-HEG could partially improve the quality of life for people with FPSH and liver-qi stagnation and spleen-qi deficiency syndrome, which can ease bodily pain, stimulate a positive mood, and ease a negative mood.
Evidence-based Complementary and Alternative Medicine 01/2012; 2012:509705. · 4.77 Impact Factor
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Tian-fang Wang,
Xiao-lin Xue, Ya-jing Zhang,
Ping Han,
Zhen Li,
Wen-ping Wang,
Jian-min Xing,
Qing-bo Wang,
Yu Tang,
Li Li,
Jia-jia Wang,
Guan-ru Li,
Shao-liang Ji,
Liu-xin Wu,
Yan Zhao,
Xiu-yan Wu,
Run-shuan Zhao
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ABSTRACT: The demand for effective intervention for subhealth conditions is growing with increasing numbers of people being in a state of subhealth with a poor quality of life. Future research and evaluation of the treatment methods for subhealth conditions from the perspective of traditional Chinese medicine (TCM) may provide an important direction for developing effective management of these conditions.
To evaluate the efficacy and safety of Xiaopi Yishen herbal extract granules (XPYS-HEG), a compound traditional Chinese herbal medicine for relieving fatigue and promoting a cheerful spirit for the treatment of people with fatigue-predominant subhealth due to liver-qi stagnation and spleen-qi deficiency. DESIGN, SETTING PARTICIPANTS AND INTERVENTIONS: A multi-center, randomized, double-blinded, placebo-controlled clinical study was undertaken. The study period was 18 weeks, including 6 weeks for intervention and 12 weeks for follow-up. Participants were recruited from medical center and outpatient clinics of three hospitals in China, i.e. Xiaotangshan Hospital of Beijing, the First Affiliated Hospital of Henan University of TCM and the Affiliated Hospital of Liaoning University of TCM. Two hundred participants who met the criteria of fatigue-predominant subhealth and liver-qi stagnation and spleen-qi deficiency in TCM were allocated randomly to the treatment group (XPYS, n=100) and control group (placebo, n=100). Main outcome measures: The total score of Fatigue Scale-14 (FS-14) was used to evaluate the fatigue status of subjects and the extent of liver-qi stagnation and spleen-qi deficiency syndrome was also recorded. Results: Three cases in the XPYS group withdrew from the trial. There were 200 subjects who entered to full analysis set (FAS) analysis and 197 subjects fitted in the per-protocol set (PPS) analysis. (1) According to the score changes of FS-14, the effectiveness rates in the XPYS and placebo group were as follows: 14.0% vs 9.0% (FAS) and 14.4% vs 9.0% (PPS) for complete remission, 19.0% vs 15.0% (FAS) and 19.6% vs 15.0% (PPS) for obvious effects, 39.0% vs 26.0% (FAS) and 39.2% vs 26.0% (PPS) for effective, and 72.0% vs 50.0% (FAS) and 73.2% vs 50.0% (PPS) for complete efficacy. The efficacy of XPYS-HEG was superior to the placebo statistically (P<0.05). (2) According to the score changes of TCM syndrome, the effectiveness rates in the XPYS group and placebo group were as follows: 1.0% vs 0.0% (FAS) and 1.0% vs 0.0% (PPS) for complete remission, 20.0% vs 7.0% (FAS) and 19.6% vs 7.0% (PPS) for obvious effects, 29.0% vs 24.0% (FAS) and 29.9% vs 24.0% (PPS) for effective, and 50.0% vs 31.0% (FAS) and 50.5% vs 31.0% (PPS) for complete efficacy. The efficacy of XPYS-HEG was superior to that of placebo statistically (P<0.05). (3) The follow-up results at 12 weeks and 18 weeks showed that the efficacy of XPYS-HEG was superior to that of placebo statistically (P<0.05). (4) No adverse effects were found in the XPYS group.
It can be concluded that XPYS-HEG is effective and safe for the treatment of people with fatigue-predominant subhealth due to liver-qi stagnation and spleen-qi deficiency.
Journal of Chinese Integrative Medicine 05/2011; 9(5):515-24.
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Tian-fang Wang,
Jia-jia Wang,
Xiao-lin Xue,
Ping Han, Ya-jing Zhang,
Guan-ru Li,
Xiu-yan Wu,
Yan Zhao,
Li-long Tang,
Yu-yue Liu,
Cong-lu Sui,
Chen Fu,
Yong-mei Shang,
Bo Zhou
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ABSTRACT: To investigate the characteristics of traditional Chinese medicine (TCM) syndromes and their elements in people with subhealth fatigue.
The TCM symptoms in line with the diagnostic criteria of subhealth fatigue status were collected by clinical investigations and using information collection form based on TCM four diagnostic methods. Referred to Clinical Guidelines of Chinese Medicine on Subhealth and other related standards, the syndrome type was identified in accordance with clinical symptoms of each patient with subhealth fatigue by two physicians. The data of syndrome differentiation were analyzed by descriptive statistical analysis.
There were 81 syndrome types from 495 cases of subhealth fatigue. There were 24 syndrome types after separation, and the top ten were liver stagnation and spleen deficiency, stagnation of liver qi, hyperactivity of liver fire, disharmony between liver and stomach, damp obstruction due to spleen deficiency, deficiency of both heart and spleen, yin deficiency of liver and kidney, yang deficiency of spleen and kidney, stagnation of gallbladder and disturbance of phlegm, and internal disturbance of phlegm-heat. There were 17 syndrome elements, including seven disease location elements and ten disease nature elements. The disease location elements were liver, spleen, kidney, stomach, heart, gallbladder and lung. The disease nature elements were qi stagnation, qi deficiency, exuberance of fire (heat), damp obstruction, phlegm obstruction, yin deficiency, adverse flow of qi, yang deficiency, blood deficiency, and blood stasis.
Syndrome types of subhealth fatigue involve in deficiency syndrome, excess syndrome, and mixture of deficiency and excess syndromes. The syndrome elements of disease location involve five zang organs and two fu organs, and the liver and spleen were the most frequently involved organs. The syndrome elements of disease nature involve deficiency and excess. Qi stagnation is most frequently involved in the excess syndrome, and qi deficiency is most frequently involved in the deficiency syndrome.
Journal of Chinese Integrative Medicine 03/2010; 8(3):220-3.
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ABSTRACT: The demand of effective interventions in subhealth is growing with more and more people being in subhealth state and poor life quality. It is important to explore how to evaluate the effects of the traditional Chinese medicine (TCM) interventions in subhealth, but it is difficult to conduct such an evaluation because of the broad meaning and varied types of subhealth, such as physical or psychological subtypes. The subtypes may be characterized by one of the symptoms like fatigue or pain, etc. Many symptoms of subhealth have no clear laboratory markers for diagnosis, and some symptoms may fluctuate with psychological and environmental factors. All of the above factors would increase the difficulty of effectiveness evaluation. The typical subtype of subhealth state and the intermediate outcome should be chosen for multidimensionally evaluating the effects of TCM interventions in subhealth at different time points.
Journal of Chinese Integrative Medicine 04/2009; 7(3):201-4.
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ABSTRACT: To investigate the impact of cyclosporine A (CsA) on atrial expression change of L-type calcium channel alpha1c subunit in a canine model of atrial fibrillation (AF).
AF was induced by rapid atrial pacing (400 beats/min) for 8 weeks in adult male dogs and placebo (n = 6) or CsA (5 mg x kg(-1) x d(-1), n = 6) were orally administered to these animals. Sham operated animals served as normal controls (n = 6). The atrial electrophysiological parameters including P wave duration, atrial effective refractory period (AERP) were recorded and analyzed at baseline and 8 weeks later. Animals were scarified at 8 weeks post final electrophysiological examinations and atrial expressions of L-type calcium channel alpha1c subunit were determined by Western blot.
Compared to sham group, the P wave duration was significantly prolonged while AERP was significantly decreased in AF and CsA groups (all P < 0.05). AERP was significantly longer in CsA group than that in AF group (P < 0.05). L-type calcium channel alpha1c subunit expression was significantly downregulated in AF group compared to sham group (P < 0.05) and CsA significantly attenuated this downregulation (P < 0.01 vs. AF group).
CsA could attenuate the downregulation of the L-type calcium channel alpha1c subunit expression and improve the atrial electrophysiological remodeling in this canine model of AF.
Zhonghua xin xue guan bing za zhi [Chinese journal of cardiovascular diseases] 02/2009; 37(2):112-4.
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ABSTRACT: To probe into the characteristics of traditional Chinese medicine syndromes and their element distributions in sub-health status.
Literatures on sub-health in past 20 years were collected, and a data bank was set up by using EpiData 2.0. The frequencies of syndromes and their elements were analyzed using SPSS 12.0.
Out of the 50 syndromes obtained from the standardization of syndrome nomenclature, and the top three were stagnation of liver-qi, deficiency of both heart and spleen, and deficiency of liver-yin and kidney-yin. Spleen, liver and kidney were the top three of all the 14 disease locations. Qi-deficiency, qi-stagnation and damp pathogen were the top three pathogenicity types.
Although the traditional Chinese medicine syndromes in sub-health status are scattered in the distribution, the main syndromes take up a leading proportion and their elements are concise and concentrated in distribution. Therefore, it is necessary to make a standard study on traditional Chinese medicine syndromes in sub-health status from syndrome elements.
Journal of Chinese Integrative Medicine 01/2009; 6(12):1290-3.
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ABSTRACT: In this paper, a gene immune detection algorithm with complement operator in the artificial immune system is proposed. Such problems as gene detection, immune memory and niching strategy in the algorithms are discussed. Application on the area of anomaly detection is considered. Shown by simulation experiments, the algorithm joined vaccine operator and complement operator improves the problem of hole and keeps variety of antibodies. And its detecting time is also decreased obviously.
Intelligent Information Hiding and Multimedia Signal Processing, 2008. IIHMSP '08 International Conference on; 09/2008
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ABSTRACT: On the basis of research for anomaly detection in the biological immune principles, a gene immune detection algorithm is provided. It combines innate immune and adaptive immune mechanism of the biological immune system. An adaptive approach that changes the thresholds of match in real time is suggested. This paper discussed some problems of anomaly detection in computer immune system. Shown by simulation experiments, the algorithm improves self-immunity and variety of antibodies. And it has such advantages as, high detecting efficiency, less computing time and adaptive character. Keywords: A nomaly detection; Immune; Vaccine operator ; Adaptive
Computational Intelligence and Security, 2007 International Conference on; 01/2008
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Advanced Intelligent Computing Theories and Applications. With Aspects of Artificial Intelligence, 4th International Conference on Intelligent Computing, ICIC 2008, Shanghai, China, September 15-18, 2008, Proceedings; 01/2008
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ABSTRACT: Based on research for anomaly detection in the biological immune principles, a change detection algorithm is provided. It synchronizes the idea of negative selection in biology, is applied for the method of scheme match and joins vaccines operator to help detection in this algorithm. And a niching strategy is adopted. This paper discussed the problem of fuzzy match and vaccine operator by comparing the two immune detection algorithms. Shown by experiments, the algorithm improves the problem of hole and keeps variety of antibodies. And its detecting efficiency is increased obviously.
Machine Learning and Cybernetics, 2005. Proceedings of 2005 International Conference on; 09/2005
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ABSTRACT: Biological immune principles provide the perfect protecting schemes for computer immune system. Based on the research on anomaly detection, a gene immune detection algorithm is presented. Innate immune mechanism and adaptive immune mechanism of the biological immune system are considered synthetically. Positive selection and vaccine mechanism are introduced and a strategy of PRI in the detection is adopted by using gene detection. As shown in the simulation experiments, the algorithm improves the variety of the antibodies. It has a rather high detecting efficiency.
Machine Learning and Cybernetics, 2004. Proceedings of 2004 International Conference on; 09/2004
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ABSTRACT: Presents a niching negative selective genetic algorithm for self-nonself discrimination in a computer. From the view point of biological immune principles, the advantages and existing problems of the negative selection algorithm as a distributed anomaly detection approach are introduced. The problem of compounding negative selection with a genetic algorithm is discussed. Experiments report that the algorithm proposed shows diversity, less time of generating detectors and efficiency.
Machine Learning and Cybernetics, 2002. Proceedings. 2002 International Conference on; 02/2002
